scholarly journals Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

2013 ◽  
Vol 55 ◽  
pp. 26-35 ◽  
Author(s):  
Yi Zhang ◽  
Anna Cook ◽  
Jinho Kim ◽  
Sergei V. Baranov ◽  
Jiying Jiang ◽  
...  
Keyword(s):  
Cell Death ◽  
Amyotrophic Lateral Sclerosis ◽  
Cytochrome C ◽  
Mouse Model ◽  
Disease Progression ◽  
Caspase 3 ◽  
Caspase 1 ◽  
Cell Death Pathway ◽  
Lateral Sclerosis

PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model

2011 ◽  
Vol 44 (6) ◽  
pp. 947-956 ◽  
Author(s):  
Huiyun Liang ◽  
Walter F. Ward ◽  
Youngmok C. Jang ◽  
Arunabh Bhattacharya ◽  
Alex F. Bokov ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Disease Progression ◽  
Lateral Sclerosis

Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

2002 ◽  
Vol 10 (3) ◽  
pp. 268-278 ◽  
Author(s):  
Jasna Kriz ◽  
Minh Dang Nguyen ◽  
Jean-Pierre Julien
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Disease Progression ◽  
Lateral Sclerosis

Molecular chaperones as therapeutic targets in amyotrophic lateral sclerosis

2005 ◽  
Vol 33 (4) ◽  
pp. 551-552 ◽  
Author(s):  
B. Kalmar ◽  
D. Kieran ◽  
L. Greensmith
Keyword(s):  
Cell Death ◽  
Amyotrophic Lateral Sclerosis ◽  
Heat Shock ◽  
Molecular Chaperones ◽  
Apoptotic Cell ◽  
Structural Repair ◽  
Cell Death Pathway ◽  
Shock Proteins ◽  
Intracellular Aggregates ◽  
Lateral Sclerosis

Neurodegenerative diseases are characterized by a number of common hallmarks, such as the presence of intracellular aggregates and activation of the apoptotic cell-death pathway. Intracellular chaperones, responsible for protein integrity and structural repair, may play a crucial role in the progression of a disease. In this paper, we aim to summarize our understanding of the role and potential of a particular family of chaperones, the heat-shock proteins, in neurodegeneration, by focusing our discussion on models of motoneuron death.

scholarly journals No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model

2005 ◽  
Vol 14 (21) ◽  
pp. 3309-3320 ◽  
Author(s):  
Florence E. Perrin ◽  
Gaelle Boisset ◽  
Mylene Docquier ◽  
Olivier Schaad ◽  
Patrick Descombes ◽  
...  
Keyword(s):  
Cell Death ◽  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Cell Death Genes ◽  
Death Genes ◽  
Lateral Sclerosis
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