Astroglial adrenoreceptors modulate synaptic transmission and contextual fear memory formation in dentate gyrus

2020 ◽  
pp. 104942
Author(s):  
Weida Shen ◽  
Shishuo Chen ◽  
Yingchun Xiang ◽  
Zheyu Yao ◽  
Zhitao Chen ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Dentate Gyrus ◽  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Contextual Fear Memory

scholarly journals AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation

2015 ◽  
Vol 41 (7) ◽  
pp. 1849-1864 ◽  
Author(s):  
Ying Han ◽  
Yixiao Luo ◽  
Jia Sun ◽  
Zengbo Ding ◽  
Jianfeng Liu ◽  
...  
Keyword(s):  
Dorsal Hippocampus ◽  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Ampk Signaling ◽  
Contextual Fear Memory

scholarly journals Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity

2015 ◽  
Vol 9 ◽  
Author(s):  
Benjamin Chew ◽  
Jae Ryun Ryu ◽  
Teclise Ng ◽  
Dongliang Ma ◽  
Ananya Dasgupta ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Dentate Gyrus ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Gsk 3Β

scholarly journals Metabolic fingerprints of fear memory consolidation during sleep

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Iyo Koyanagi ◽  
Kazuhiro Sonomura ◽  
Toshie Naoi ◽  
Takaaki Ohnishi ◽  
Naoko Kaneko ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Memory Consolidation ◽  
Conditioned Fear ◽  
Fear Memory ◽  
State Transitions ◽  
Contextual Fear ◽  
Memory Processing ◽  
Contextual Fear Memory ◽  
Purine Metabolites ◽  
Wake State

AbstractMetabolites underlying brain function and pathology are not as well understood as genes. Here, we applied a novel metabolomics approach to further understand the mechanisms of memory processing in sleep. As hippocampal dentate gyrus neurons are known to consolidate contextual fear memory, we analyzed real-time changes in metabolites in the dentate gyrus in different sleep–wake states in mice. Throughout the study, we consistently detected more than > 200 metabolites. Metabolite profiles changed dramactically upon sleep–wake state transitions, leading to a clear separation of phenotypes between wakefulness and sleep. By contrast, contextual fear memory consolidation induced less obvious metabolite phenotypes. However, changes in purine metabolites were observed upon both sleep–wake state transitions and contextual fear memory consolidation. Dietary supplementation of certain purine metabolites impaired correlations between conditioned fear responses before and after memory consolidation. These results point toward the importance of purine metabolism in fear memory processing during sleep.

scholarly journals Females, but not males, require protein degradation in the hippocampus for contextual fear memory formation

2021 ◽  
Vol 28 (8) ◽  
pp. 248-253
Author(s):  
Kiley Martin ◽  
Madeline Musaus ◽  
Shaghayegh Navabpour ◽  
Aspen Gustin ◽  
W. Keith Ray ◽  
...  
Keyword(s):  
Protein Degradation ◽  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Contextual Fear Memory

scholarly journals Ontogeny of contextual fear memory formation, specificity, and persistence in mice

2012 ◽  
Vol 19 (12) ◽  
pp. 598-604 ◽  
Author(s):  
K. G. Akers ◽  
M. Arruda-Carvalho ◽  
S. A. Josselyn ◽  
P. W. Frankland
Keyword(s):  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Contextual Fear Memory

miR-187-3p participates in contextual fear memory formation through modulating SATB2 expression in the hippocampus

Neuroreport ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Cui Zhao ◽  
Bo Zhou ◽  
Junjie Cao ◽  
Yafang Zhang ◽  
Wei Li ◽  
...  
Keyword(s):  
Fear Memory ◽  
Memory Formation ◽  
Contextual Fear ◽  
Contextual Fear Memory
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