Contrasting genetic effects of major histocompatibility complex on ischemic peripheral nerve and spinal cord injury in female rats

2008 ◽  
Vol 443 (2) ◽  
pp. 95-98 ◽  
Author(s):  
Cecilia A. Dominguez ◽  
Olle Lidman ◽  
Tomas Olsson ◽  
Zsuzsanna Wiesenfeld-Hallin ◽  
Fedrik Piehl ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Major Histocompatibility Complex ◽  
Peripheral Nerve ◽  
Genetic Effects ◽  
Female Rats ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Cord Injury

Recovery from spinal cord injury differs between rat strains in a major histocompatibility complex-independent manner

2007 ◽  
Vol 26 (5) ◽  
pp. 1118-1127 ◽  
Author(s):  
M. Birdsall Abrams ◽  
Anna Josephson ◽  
Cecilia Dominguez ◽  
Johanna Öberg ◽  
Margarita Diez ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Rat Strains ◽  
Independent Manner ◽  
Histocompatibility Complex ◽  
Cord Injury

scholarly journals Morphological changes in the sciatic nerve in experimental modeling of contusion injury of the spinal cord in rats

2021 ◽  
Vol 18 (3) ◽  
pp. 36-42
Author(s):  
N. V. Kubrak ◽  
T. N. Varsegova ◽  
S. O. Ryabykh
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Morphological Changes ◽  
Female Rats ◽  
Nerve Tissue ◽  
Motor Deficit ◽  
Cord Injury ◽  
Contusion Injury

Objective. To analyze morphological and morphometric changes in the sciatic nerve of rats after the spinal cord injury.Material and Methods. The Т9 moderately severe contusion injury of the spinal cord was simulated in 12 Wistar female rats. Functions of the pelvic limbs were assessed according to the standardized BBB scale. The animals were withdrawn from the experiment after nine and 13 weeks. Epoxy semi-thin (1 µm) sections were used to study sciatic nerve at the light-optical level.Results. Significant recovery of pelvic limb functions was observed within four weeks after surgery, the plateau was achieved by Week 5 (9.5 ± 0.28 points according to the BBB scale), the deterioration in the motor activity was observed by Week 9 (8.67 ± 0.33), its recovery was achieved by Week 13 of the experiment (9.5 ± 0.87). After 9 and 13 weeks, reactive-destructive changes were detected in the sciatic nerve in 9 % and 8 % of nerve conductors, an increase in the number density of myelin fibers by 28 % and 27 % (p < 0.05) and myelin-free fibers by 20 % and 49 % (p < 0.05), and a decrease in axon diameters by 8 % and 10 % (p < 0.05), respectively.Conclusions. The morphological and morphometric changes in the sciatic nerve revealed after the spinal cord injury in the form of destruction of a part of the fibers, axonal atrophy and a decrease in the proportion of large fibers negatively affect its conductive properties. The leveling of peripheral nerve damage, possibly, will accelerate the regression of the motor deficit caused by the spinal cord injury; therefore, it is necessary to develop a set of preventive measures aimed at preventing the reorganization of the peripheral nerve tissue.

Transplantation Strategies for Spinal Cord Injury Based on Microenvironment Modulation

2020 ◽  
Vol 15 (6) ◽  
pp. 522-530
Author(s):  
Jiawei Shu ◽  
Feng Cheng ◽  
Zhe Gong ◽  
Liwei Ying ◽  
Chenggui Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Autonomic Dysfunction ◽  
Peripheral Nerve Injury ◽  
Therapeutic Effects ◽  
Permanent Damage ◽  
Cord Injury ◽  
Severe Motor

Spinal cord injury (SCI) is different from peripheral nerve injury; it results in devastating and permanent damage to the spine, leading to severe motor, sensory and autonomic dysfunction. SCI produces a complex microenvironment that can result in hemorrhage, inflammation and scar formation. Not only does it significantly limit regeneration, but it also challenges a multitude of transplantation strategies. In order to promote regeneration, researchers have recently begun to focus their attention on strategies that manipulate the complicated microenvironment produced by SCI. And some have achieved great therapeutic effects. Hence, reconstructing an appropriate microenvironment after transplantation could be a potential therapeutic solution for SCI. In this review, first, we aim to summarize the influential compositions of the microenvironment and their different effects on regeneration. Second, we highlight recent research that used various transplantation strategies to modulate different microenvironments produced by SCI in order to improve regeneration. Finally, we discuss future transplantation strategies regarding SCI.

scholarly journals Percutaneous peripheral nerve stimulation for treatment of shoulder pain after spinal cord injury: A case report

2017 ◽  
Vol 41 (1) ◽  
pp. 119-124 ◽  
Author(s):  
Daniela Mehech ◽  
Melvin Mejia ◽  
Gregory A. Nemunaitis ◽  
John Chae ◽  
Richard D. Wilson
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Case Report ◽  
Peripheral Nerve ◽  
Shoulder Pain ◽  
Nerve Stimulation ◽  
Peripheral Nerve Stimulation ◽  
Cord Injury

scholarly journals EA Improves the Motor Function in Rats with Spinal Cord Injury by Inhibiting Signal Transduction of Semaphorin3A and Upregulating of the Peripheral Nerve Networks

2020 ◽  
Vol 2020 ◽  
pp. 1-15
Author(s):  
Rong Hu ◽  
Haipeng Xu ◽  
Yaheng Jiang ◽  
Yi Chen ◽  
Kelin He ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peripheral Nerve ◽  
Motor Function ◽  
Gray Matter ◽  
Ventral Horn ◽  
Damage Site ◽  
Central Tube ◽  
Spinal Cord Segment ◽  
Cord Injury

Peripheral nerve networks (PNNs) play a vital role in the neural recovery after spinal cord injury (SCI). Electroacupuncture (EA), as an alternative medicine, has been widely used in SCI and was proven to be effective on neural functional recovery. In this study, the interaction between PNNs and semaphrin3A (Sema3A) in the recovery of the motor function after SCI was observed, and the effect of EA on them was evaluated. After the establishment of the SCI animal model, we found that motor neurons in the ventral horn of the injured spinal cord segment decreased, Nissl bodies were blurry, and PNNs and Sema3A as well as its receptor neuropilin1 (NRP1) aggregated around the central tube of the gray matter of the spinal cord. When we knocked down the expression of Sema3A at the damage site, NRP1 also downregulated, importantly, PNNs concentration decreased, and tenascin-R (TN-R) and aggrecan were also reduced, while the Basso-Beattie-Bresnahan (BBB) motor function score dramatically increased. In addition, when conducting EA stimulation on Jiaji (EX-B2) acupoints, the highly upregulated Sema3A and NRP1 were reversed post-SCI, which can lessen the accumulation of PNNs around the central tube of the spinal cord gray matter, and simultaneously promote the recovery of motor function in rats. These results suggest that EA may further affect the plasticity of PNNs by regulating the Sema3A signal and promoting the recovery of the motor function post-SCI.

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