Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice

2010 ◽  
Vol 476 (2) ◽  
pp. 66-69 ◽  
Author(s):  
Dean E. Dluzen ◽  
Jing Ji ◽  
Janet L. McDermott
Keyword(s):  
Dopamine Transporter ◽  
Knock Out ◽  
Age Related ◽  
Knock Out Mice ◽  
Age Related Changes

Age-related differences in MK-801 induced behaviors in dopamine D3 receptor knock out mice

2010 ◽  
Vol 627 (1-3) ◽  
pp. 177-184
Author(s):  
Alex V. Iarkov ◽  
Terry C. Der ◽  
Jeffrey N. Joyce
Keyword(s):  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Knock Out ◽  
Mk 801 ◽  
Age Related ◽  
Dopamine D3 ◽  
Knock Out Mice

scholarly journals Inner ear pathology and loss of hearing in estrogen receptor-β deficient mice

2009 ◽  
Vol 201 (3) ◽  
pp. 397-406 ◽  
Author(s):  
Rusana Simonoska ◽  
Annika E Stenberg ◽  
Maoli Duan ◽  
Konstantin Yakimchuk ◽  
Anders Fridberger ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Inner Ear ◽  
Spiral Ganglion ◽  
Organ Of Corti ◽  
Auditory Brainstem ◽  
Estrogen Receptor Β ◽  
Knock Out ◽  
Age Related ◽  
Brainstem Response ◽  
Knock Out Mice

There are well known differences between males and females in hearing. In the present study, the role of estrogen receptor-β (ER-β; listed as ESR2 in the MGI Database) in hearing was investigated by comparing hearing and morphology of the inner ear in ER-β knock-out mice (ER-β−/−) with that of wild-type (WT) littermates. Hearing was analyzed with auditory brainstem response audiometry at 3 and 12 months. The ER-β−/− mice were deaf at 1 year of age, and the morphological analysis showed absence of hair cells and loss of the whole organ of Corti initiated in the basal turn of the cochlea. Furthermore, in ER-β−/−, but not in WT mice, the spiral ganglion was lacking many of its neurons. Immunostaining showed the presence of both ER-α (listed as ESR1 in the MGI Database) and ER-β in the nuclei of some neurons in the inner ear in WT mice, but no ER-β was found in the ER-β−/− mice as expected. ER-α staining was predominant in the nuclei of large neurons and ER-β in nuclei of small neurons and fibroblasts. These results reveal that both ERs are present in the inner ear at specific localizations suggesting subtype-specific functions. It is concluded that ER-β is important for the prevention of age-related hearing loss. These findings strengthen the hypothesis that estrogen has a direct effect on hearing functions.

Dopamine transporter knock-out mice are hypersensitive to 3-nitropropionic acid-induced striatal damage

2002 ◽  
Vol 15 (12) ◽  
pp. 2053-2056 ◽  
Author(s):  
Pierre-O. Fernagut ◽  
Elsa Diguet ◽  
Mohamed Jaber ◽  
Bernard Bioulac ◽  
François Tison
Keyword(s):  
Dopamine Transporter ◽  
Knock Out ◽  
Nitropropionic Acid ◽  
Knock Out Mice ◽  
3 Nitropropionic Acid

Functional hyperdopaminergia in dopamine transporter knock-out mice

1999 ◽  
Vol 46 (3) ◽  
pp. 303-311 ◽  
Author(s):  
Raul R Gainetdinov ◽  
Sara R Jones ◽  
Marc G Caron
Keyword(s):  
Dopamine Transporter ◽  
Knock Out ◽  
Knock Out Mice

Decreased Ethanol Preference and Consumption in Dopamine Transporter Female Knock-Out Mice

2002 ◽  
Vol 26 (6) ◽  
pp. 758-764 ◽  
Author(s):  
Katerina V. Savelieva ◽  
W. Michael Caudle ◽  
Geoffrey S. Findlay ◽  
Marc G. Caron ◽  
Gary W. Miller
Keyword(s):  
Dopamine Transporter ◽  
Ethanol Preference ◽  
Knock Out ◽  
Knock Out Mice

scholarly journals Lack of Cocaine Effect on Dopamine Clearance in the Core and Shell of the Nucleus Accumbens of Dopamine Transporter Knock-Out Mice

2002 ◽  
Vol 22 (10) ◽  
pp. RC222-RC222 ◽  
Author(s):  
Evgeny A. Budygin ◽  
Carrie E. John ◽  
Yolanda Mateo ◽  
Sara R. Jones
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Transporter ◽  
Knock Out ◽  
The Core ◽  
Knock Out Mice
Sign in / Sign up

Export Citation Format

Share Document