Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures

2011 ◽  
Vol 497 (3) ◽  
pp. 185-193 ◽  
Author(s):  
Nigel C. Jones ◽  
Terence J. O’Brien ◽  
Kim L. Powell
Keyword(s):  
Molecular Mechanisms ◽  
Idiopathic Generalized Epilepsy ◽  
Absence Seizures ◽  
Rat Models ◽  
Generalized Epilepsy

scholarly journals Automatisms in Absence Seizures in Children With Idiopathic Generalized Epilepsy

2009 ◽  
Vol 66 (6) ◽  
Author(s):  
Lynette G. Sadleir ◽  
Ingrid E. Scheffer ◽  
Sherry Smith ◽  
Mary B. Connolly ◽  
Kevin Farrell
Keyword(s):  
Idiopathic Generalized Epilepsy ◽  
Absence Seizures ◽  
Generalized Epilepsy

Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy: A Case Report

Neurosurgery ◽  
2020 ◽  
Vol 87 (5) ◽  
pp. E578-E583 ◽  
Author(s):  
Vasileios Kokkinos ◽  
Alexandra Urban ◽  
Nathaniel D Sisterson ◽  
Ningfei Li ◽  
Danielle Corson ◽  
...  
Keyword(s):  
Case Report ◽  
Neural Activity ◽  
Seizure Control ◽  
Clinical Presentation ◽  
Idiopathic Generalized Epilepsy ◽  
Absence Seizures ◽  
Level Of Consciousness ◽  
Spike Wave Discharges ◽  
Generalized Epilepsy ◽  
Spike Wave

Abstract BACKGROUND AND IMPORTANCE At least 25% of patients with idiopathic generalized epilepsy do not obtain adequate seizure control with medication. This report describes the first use of responsive neurostimulation (RNS), bilaterally targeting the centromedian/ventrolateral (CM/VL) region in a patient with drug-refractory Jeavons syndrome (eyelid myoclonia with absences). CLINICAL PRESENTATION A patient, diagnosed with eyelid myoclonia with absences (EMA) and refractory to medication, was offered RNS treatment in the CM/VL region of the thalamus. Stimulation was triggered by thalamic neural activity having morphological, spectral, and synchronous features that corresponded to 3- to 5-Hz spike-wave discharges recorded on prior scalp electroencephalography. CONCLUSION RNS decreased daily absence seizures from a mean of 60 to ≤10 and maintained the patient's level of consciousness during the occurring episodes. This therapy should be evaluated further for its potential to treat patients with pharmaco-refractory generalized epilepsy.

scholarly journals Adjunctive perampanel and myoclonic and absence seizures: Post hoc analysis of data from study 332 in patients with idiopathic generalized epilepsy

Seizure ◽  
2020 ◽  
Vol 80 ◽  
pp. 115-123
Author(s):  
Christian Brandt ◽  
Robert T. Wechsler ◽  
Terence J. O’Brien ◽  
Anna Patten ◽  
Manoj Malhotra ◽  
...  
Keyword(s):  
Idiopathic Generalized Epilepsy ◽  
Absence Seizures ◽  
Post Hoc Analysis ◽  
Generalized Epilepsy ◽  
Post Hoc

scholarly journals Exceptional response to brivaracetam in a patient with refractory idiopathic generalized epilepsy and absence seizures

2018 ◽  
Vol 20 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Alberto Grande-Martín ◽  
David Sopelana-Garay ◽  
José Manuel Pardal-Fernández ◽  
Rosa María Sánchez-Honrubia ◽  
Álvaro Abelardo Sánchez-Larsen
Keyword(s):  
Idiopathic Generalized Epilepsy ◽  
Absence Seizures ◽  
Generalized Epilepsy

scholarly journals EEG features of absence seizures in idiopathic generalized epilepsy: Impact of syndrome, age, and state

Epilepsia ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1572-1578 ◽  
Author(s):  
Lynette Grant Sadleir ◽  
Ingrid E. Scheffer ◽  
Sherry Smith ◽  
Bendix Carstensen ◽  
Kevin Farrell ◽  
...  
Keyword(s):  
Idiopathic Generalized Epilepsy ◽  
Absence Seizures ◽  
Generalized Epilepsy ◽  
Eeg Features

A New SYNGAP1 Stop Mutation in a Patient with Idiopathic Generalized Epilepsy Showing Photosensitivity and Electroencephalography Normalization after Eye Opening

2014 ◽  
Vol 45 (S 01) ◽  
Author(s):  
C. von Stülpnagel-Steinbeis ◽  
C. Funke ◽  
C. Haberl ◽  
K. Hörtnagel ◽  
J. Jüngling ◽  
...  
Keyword(s):  
Idiopathic Generalized Epilepsy ◽  
Stop Mutation ◽  
Eye Opening ◽  
Generalized Epilepsy
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