Association between the SORL1 rs2070045 polymorphism and late-onset Alzheimer's disease: Interaction with the ApoE genotype in the Chinese Han population

2014 ◽  
Vol 559 ◽  
pp. 94-98 ◽  
Author(s):  
Xiaofan Xue ◽  
Milan Zhang ◽  
Yicong Lin ◽  
Erhe Xu ◽  
Jianping Jia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Apoe Genotype ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer’s Disease in Chinese Han Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63621 ◽  
Author(s):  
Wei Xu ◽  
Jun Xu ◽  
Ying Wang ◽  
Huidong Tang ◽  
Yulei Deng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Variation ◽  
Late Onset ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Association Study of Clusterin Polymorphism rs11136000 With Late Onset Alzheimer’s Disease in Chinese Han Population

2011 ◽  
Vol 26 (8) ◽  
pp. 627-630 ◽  
Author(s):  
Jian-Fang Ma ◽  
Li-hua Liu ◽  
Yu Zhang ◽  
Ying Wang ◽  
Yu-Lei Deng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Meta Analysis ◽  
Recessive Model ◽  
Chinese Han Population ◽  
Published Data ◽  
Chinese Han ◽  
Han Population ◽  
Pcr Rflp

Objective: We conducted a case–control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer’s disease in Chinese Han population. Methods: Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer’s disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis. Results: APOEε4 was demonstrated to increase the risk of Alzheimer’s disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer’s disease and controls following a recessive model. Conclusion: Clusterin (rs11136000) was associated with Alzheimer’s disease in Chinese Han population.

scholarly journals Interaction between PPAR γ and SORL1 gene with Late-Onset Alzheimer’s disease in Chinese Han Population

Oncotarget ◽  
2017 ◽  
Vol 8 (29) ◽  
pp. 48313-48320 ◽  
Author(s):  
Hui Zhang ◽  
Wei Zheng ◽  
Linlin Hua ◽  
Yutong Wang ◽  
Jinfeng Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Ppar Γ ◽  
Sorl1 Gene

Association study ofTREM2polymorphism rs75932628 with late-onset Alzheimer’s disease in Chinese Han population

2014 ◽  
Vol 36 (10) ◽  
pp. 894-896 ◽  
Author(s):  
Jianfang Ma ◽  
Yi Zhou ◽  
Jun Xu ◽  
Xiaohong Liu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Late Onset ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer’s disease in the Chinese Han population

2015 ◽  
Vol 593 ◽  
pp. 56-60 ◽  
Author(s):  
Huacheng Yan ◽  
Yanying Kong ◽  
Baoxia He ◽  
Mukun Huang ◽  
Jian Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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