Effect of opioid receptors of the cuneiform nucleus on cardiovascular responses in normotensive and hypotensive hemorrhagic rats

2020 ◽  
pp. 135582
Author(s):  
Reza Mohebbati ◽  
Abolfazl Khajavi Rad ◽  
Mahmoud Hosseini ◽  
Mohammad Naser Shafei
Keyword(s):  
Opioid Receptors ◽  
Cardiovascular Responses ◽  
Cuneiform Nucleus

scholarly journals κ-Opioid receptors in the infralimbic cortex modulate the cardiovascular responses to acute stress

2015 ◽  
Vol 100 (4) ◽  
pp. 377-387 ◽  
Author(s):  
Aline Fassini ◽  
América A. Scopinho ◽  
Leonardo B. M. Resstel ◽  
Fernando M. A. Corrêa
Keyword(s):  
Opioid Receptors ◽  
Acute Stress ◽  
Cardiovascular Responses ◽  
Infralimbic Cortex

Modulation of cardiovascular excitatory responses in rats by transcutaneous magnetic stimulation: role of the spinal cord

2006 ◽  
Vol 100 (3) ◽  
pp. 926-932 ◽  
Author(s):  
Wei Zhou (Yi Syuu) ◽  
Ian Hsiao ◽  
Vernon W. H. Lin ◽  
John C. Longhurst
Keyword(s):  
Spinal Cord ◽  
Median Nerve ◽  
Opioid Receptors ◽  
Magnetic Stimulation ◽  
Pressor Response ◽  
Intrathecal Injection ◽  
Cardiovascular Responses ◽  
Opioid Antagonist ◽  
Gastric Distension ◽  
Cardiovascular Reflex

This study investigated the efficacy of magnetic stimulation on the reflex cardiovascular responses induced by gastric distension in anesthetized rats and compared these responses to those influenced by electroacupuncture (EA). Unilateral magnetic stimulation (30% intensity, 2 Hz) at the Jianshi-Neiguan acupoints (pericardial meridian, P 5–6) overlying the median nerve on the forelimb for 24 min significantly decreased the reflex pressor response by 32%. This effect was noticeable by 20 min of magnetic stimulation and continued for 24 min. Median nerve denervation abolished the inhibitory effect of magnetic stimulation, indicating the importance of somatic afferent input. Unilateral EA (0.3–0.5 mA, 2 Hz) at P 5–6 using similar durations of stimulation similarly inhibited the response (35%). The inhibitory effects of EA occurred earlier and were marginally longer (20 min) than magnetic stimulation. Magnetic stimulation at Guangming-Xuanzhong acupoints (gallbladder meridian, GB 37–39) overlying the superficial peroneal nerve on the hindlimb did not attenuate the reflex. Intravenous naloxone immediately after termination of magnetic stimulation reversed inhibition of the cardiovascular reflex, suggesting involvement of the opioid system. Also, intrathecal injection of δ- and κ-opioid receptors antagonists, ICI174,864 ( n = 7) and nor-binaltorphimine ( n = 6) immediately after termination of magnetic stimulation reversed inhibition of the cardiovascular reflex. In contrast, the μ-opioid antagonist CTOP ( n = 7) failed to alter the cardiovascular reflex. The endogenous neurotransmitters for δ- and κ-opioid receptors, enkephalins and dynorphin but not β-endorphin, therefore appear to play significant roles in the spinal cord in mediating magnetic stimulation-induced modulation of cardiovascular reflex responses.

Opioid receptors in the prelimbic cortex modulate restraint stress-induced cardiovascular responses in the rat

2014 ◽  
Vol 85 ◽  
pp. 367-374 ◽  
Author(s):  
Aline Fassini ◽  
América A. Scopinho ◽  
Leonardo B.M. Resstel ◽  
Fernando M.A. Correa
Keyword(s):  
Opioid Receptors ◽  
Restraint Stress ◽  
Cardiovascular Responses ◽  
Prelimbic Cortex

In Search of Somatic Precursors of Spontaneous Insight

2018 ◽  
Vol 32 (3) ◽  
pp. 97-105 ◽  
Author(s):  
Wangbing Shen ◽  
Yuan Yuan ◽  
Chaoying Tang ◽  
Chunhua Shi ◽  
Chang Liu ◽  
...  
Keyword(s):  
Problem Solving ◽  
Direct Evidence ◽  
Electrodermal Activity ◽  
Cardiovascular Responses ◽  
Solution Time ◽  
Problem Solution ◽  
Insight Problem ◽  
Creative Insight ◽  
Insight Problem Solving ◽  
Analytic Problem

Abstract. A considerable number of behavioral and neuroscientific studies on insight problem solving have revealed behavioral and neural correlates of the dynamic insight process; however, somatic correlates, particularly somatic precursors of creative insight, remain undetermined. To characterize the somatic precursor of spontaneous insight, 22 healthy volunteers were recruited to solve the compound remote associate (CRA) task in which a problem can be solved by either an insight or an analytic strategy. The participants’ peripheral nervous activities, particularly electrodermal and cardiovascular responses, were continuously monitored and separately measured. The results revealed a greater skin conductance magnitude for insight trials than for non-insight trials in the 4-s time span prior to problem solutions and two marginally significant correlations between pre-solution heart rate variability (HRV) and the solution time of insight trials. Our findings provide the first direct evidence that spontaneous insight in problem solving is a somatically peculiar process that is distinct from the stepwise process of analytic problem solving and can be represented by a special somatic precursor, which is a stronger pre-solution electrodermal activity and a correlation between problem solution time and certain HRV indicators such as the root mean square successive difference (RMSSD).

Three Technical Approaches for Cloning Opioid Receptors

1988 ◽  
Author(s):  
Curtis A. Machida ◽  
John Salon ◽  
David Grandy ◽  
James Bunzow ◽  
Paul Albert ◽  
...  
Keyword(s):  
Opioid Receptors
Sign in / Sign up

Export Citation Format

Share Document