With the COVID-19 outbreak, the population was suddenly forced to “stay at home”. Although research suggests that social isolation affects health and wellbeing, reactions may vary depending on individuals, and their preference for solitude. This study aimed to identify personality profiles, and examine whether these profiles were associated with affective and cognitive outcomes. French respondents (N = 430) filled in an online questionnaire during the lockdown in Spring 2020. The questionnaire comprised information on lockdown conditions, measures of psychological adjustment and performance on a series of creative tasks. Based on measures of individuals’ preference for solitude, extraversion, emotional stability and openness, the cluster analysis revealed three profiles: “Affiliation”, “Emotionally Stable Lonely” and “Emotionally Unstable Lonely”. Results showed that individuals with “Affiliation” and “Emotionally Unstable Lonely” profile expressed higher stress and anxiety, and the latter performed better on a divergent creative thinking task. By contrast, those with an “Emotionally Stable Lonely” profile expressed a lower level of loneliness, and performed better on a creative insight task. These findings reveal the importance of personality profiles in psychological reactions during lockdowns. With this knowledge, health professionals could develop appropriate interventions to accompany high-risk individuals in situations of social isolation.