κ-Opioid receptors in the infralimbic cortex modulate the cardiovascular responses to acute stress

Instructed use of reappraisal to regulate stress in the laboratory is typically associated with a more adaptive cardiovascular response to stress, indexed by either: (i) lower cardiovascular reactivity (CVR; e.g., lower blood pressure); or (ii) a challenge-oriented response profile (i.e., greater cardiac output paired with lower total peripheral resistance). In contrast, instructed use of suppression is associated with exaggerated CVR (e.g., greater heart rate, blood pressure). Despite this, few studies have examined if the habitual use of these strategies are related to cardiovascular responding during stress. The current study examined the relationship between cardiovascular responses to acute stress and individual differences in emotion regulation style: trait reappraisal, suppression, and emotion regulation difficulties. Forty-eight participants (25 women, 23 men) completed a standardised laboratory stress paradigm incorporating a 20-minute acclimatization period, a 10-minute baseline, and two 5-minute speech tasks separated by a 10-minute inter-task rest period. The emotional valence of the speech task was examined as a potential moderating factor; participants spoke about a block of negative-emotion words and a block of neutral-emotion words. Cardiovascular parameters were measured using the Finometer Pro. Greater habitual use of suppression was associated with exaggerated blood pressure responding to both tasks. However, only in response to the negative-emotion task was greater use of reappraisal associated with a challenge-oriented cardiovascular response. The findings suggest that individual differences in emotion regulation translate to differing patterns of CVR to stress, but the emotional valence of the stressor may play a role.

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Acute Stress Facilitates LTD Induction at Glutamatergic Synapses in the Hippocampal CA1 Region by Activating μ-Opioid Receptors on GABAergic Neurons

Frontiers in Neuroscience ◽

10.3389/fnins.2019.00071 ◽

2019 ◽

Vol 13 ◽

Cited By ~ 4

Author(s):

Ka-Min Fan ◽

Li-Juan Qiu ◽

Ning Ma ◽

Yi-Nan Du ◽

Zhao-Qiang Qian ◽

...

Keyword(s):

Opioid Receptors ◽

Acute Stress ◽

Gabaergic Neurons ◽

Glutamatergic Synapses ◽

Ca1 Region ◽

Hippocampal Ca1 Region ◽

Hippocampal Ca1 ◽

Μ Opioid Receptors

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Decreased reaction time variability is associated with greater cardiovascular responses to acute stress

Psychophysiology ◽

10.1111/psyp.12617 ◽

2016 ◽

Vol 53 (5) ◽

pp. 739-748 ◽

Cited By ~ 7

Author(s):

Andrew J. Wawrzyniak ◽

Mark Hamer ◽

Andrew Steptoe ◽

Romano Endrighi

Keyword(s):

Reaction Time ◽

Acute Stress ◽

Cardiovascular Responses ◽

Time Variability ◽

Reaction Time Variability

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Trajectories of maternal depressive symptoms over her child's life span: Relation to adrenocortical, cardiovascular, and emotional functioning in children

Development and Psychopathology ◽

10.1017/s0954579409000133 ◽

2009 ◽

Vol 21 (1) ◽

pp. 207-225 ◽

Cited By ~ 45

Author(s):

Brooks B. Gump ◽

Jacki Reihman ◽

Paul Stewart ◽

Ed Lonky ◽

Tom Darvill ◽

...

Keyword(s):

Depressive Symptoms ◽

Depressive Symptom ◽

Life Span ◽

Acute Stress ◽

Depression Scale ◽

Cardiovascular Responses ◽

Epidemiological Studies ◽

Maternal Depressive Symptoms ◽

Symptom Trajectories ◽

Maternal Depressive Symptom

AbstractMaternal depression has a number of adverse effects on children. In the present study, maternal depressive symptoms were assessed (using the Center for Epidemiological Studies Depression Scale) when their child was 3 months, 6 months, 1 year, 2 years, 4.25 years, 6 years, 7 years, 8 years, and 10 years of age. At 9.5 years of age, children's (94 females, 82 males) depressive symptoms as well as cardiovascular and cortisol levels during baseline and two psychologically stressful tasks were measured. Using multilevel modeling, maternal depressive symptom trajectories were considered in relation to their child's adrenocortical and cardiovascular responses to acute stress. Our goal was to determine maternal depressive symptom trajectories for children with elevated cardiovascular and cortisol reactivity to acute stress and elevated depressive symptoms. In general, those mothers with chronically elevated depressive symptoms over their child's life span had children with lower initial cortisol, higher cardiac output and stroke volume in response to acute stress, lower vascular resistance during acute stress tasks, and significantly more depressive symptoms at 9.5 years of age. These results are discussed in the context of established associations among hypothalamic–pituitary–adrenal axis dysregulation, depression, and cardiovascular disease.

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Central oxytocin modulation of acute stress-induced cardiovascular responses after myocardial infarction in the rat

Stress ◽

10.1080/10253890802687688 ◽

2009 ◽

pp. 1-1 ◽

Cited By ~ 1

Author(s):

Agnieszka Wsoł ◽

Agnieszka Cudnoch-JĘdrzejewska ◽

Ewa Szczepanska-Sadowska ◽

Stanisław Kowalewski ◽

Jakub Dobruch

Keyword(s):

Myocardial Infarction ◽

Acute Stress ◽

Cardiovascular Responses

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Menstrual Cycle Effects on Catecholamine and Cardiovascular Responses to Acute Stress in Black but Not White Normotensive Women

Hypertension ◽

10.1161/01.hyp.27.4.962 ◽

1996 ◽

Vol 27 (4) ◽

pp. 962-967 ◽

Cited By ~ 23

Author(s):

Paul J. Mills ◽

Richard A. Nelesen ◽

Michael G. Ziegler ◽

Barbara L. Parry ◽

Charles C. Berry ◽

...

Keyword(s):

Menstrual Cycle ◽

Acute Stress ◽

Cardiovascular Responses

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Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00776.2014 ◽

2015 ◽

Vol 308 (6) ◽

pp. H612-H622 ◽

Cited By ~ 26

Author(s):

Benedek Erdos ◽

Iara Backes ◽

Michael L. McCowan ◽

Linda F. Hayward ◽

Deborah A. Scheuer

Keyword(s):

Blood Pressure ◽

Weight Loss ◽

Stress Responses ◽

Neurotrophic Factor ◽

Fluorescent Protein ◽

Acute Stress ◽

Cardiovascular Responses ◽

Brain Derived Neurotrophic Factor ◽

Bdnf Expression ◽

Intracerebroventricular Infusion

Brain-derived neurotrophic factor (BDNF) expression increases in the paraventricular nucleus of the hypothalamus (PVN) in response to hypertensive stimuli including stress and hyperosmolarity. However, it is unclear whether BDNF in the PVN contributes to increases in blood pressure (BP). We tested the hypothesis that increased BDNF levels within the PVN would elevate baseline BP and heart rate (HR) and cardiovascular stress responses by altering central angiotensin signaling. BP was recorded using radiotelemetry in male Sprague-Dawley rats after bilateral PVN injections of adeno-associated viral vectors expressing green fluorescent protein (GFP) or myc epitope-tagged BDNF fusion protein. Cardiovascular responses to acute stress were evaluated 3 to 4 wk after injections. Additional GFP and BDNF-treated animals were equipped with osmotic pumps for intracerebroventricular infusion of saline or the angiotensin type-1 receptor (AT1R) inhibitor losartan (15 μg·0.5 μl−1·h−1). BDNF treatment significantly increased baseline BP (121 ± 3 mmHg vs. 99 ± 2 mmHg in GFP), HR (394 ± 9 beats/min vs. 314 ± 4 beats/min in GFP), and sympathetic tone indicated by HR- and BP-variability analysis and adrenomedullary tyrosine hydroxylase protein expression. In contrast, body weight and BP elevations to acute stressors decreased. BDNF upregulated AT1R mRNA by ∼80% and downregulated Mas receptor mRNA by ∼50% in the PVN, and losartan infusion partially inhibited weight loss and increases in BP and HR in BDNF-treated animals without any effect in GFP rats. Our results demonstrate that BDNF overexpression in the PVN results in sympathoexcitation, BP and HR elevations, and weight loss that are mediated, at least in part, by modulating angiotensin signaling in the PVN.

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