Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia

2022 ◽  
Vol 769 ◽  
pp. 136386
Author(s):  
Min Hyung Seo ◽  
Bo-Ram Jin ◽  
Hyo-Jung Kim ◽  
Hyo-Jin An ◽  
Sujung Yeo
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Tyrosine Hydroxylase ◽  
Substantia Nigra ◽  
Rat Model ◽  
Prostatic Hyperplasia

The Antihyperplastic Effect of Oral Catechin Ingestion in a Rat Model of Benign Prostatic Hyperplasia

2006 ◽  
Vol 47 (12) ◽  
pp. 1289 ◽  
Author(s):  
Duk Jin Park ◽  
Sung Hak Kang ◽  
Yong-Hyun Cho
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Rat Model ◽  
Prostatic Hyperplasia

scholarly journals Benign prostatic hyperplasia treatment using plasmonic nanoparticles irradiated by laser in a rat model

2020 ◽  
Vol 127 ◽  
pp. 110118
Author(s):  
Omid Koohi Hosseinabadi ◽  
Mohammad Ali Behnam ◽  
Arezoo Khoradmehr ◽  
Farzin Emami ◽  
Zahra Sobhani ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Rat Model ◽  
Prostatic Hyperplasia ◽  
Plasmonic Nanoparticles

LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia

The Prostate ◽  
2010 ◽  
Vol 71 (7) ◽  
pp. 736-747 ◽  
Author(s):  
Ferenc G. Rick ◽  
Andrew V. Schally ◽  
Norman L. Block ◽  
Gabor Halmos ◽  
Roberto Perez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factors ◽  
Benign Prostatic Hyperplasia ◽  
Proinflammatory Cytokines ◽  
Rat Model ◽  
Prostatic Hyperplasia ◽  
Prostate Size ◽  
Lhrh Antagonist

scholarly journals Benign prostatic hyperplasia complicated with T1DM can be alleviated by treadmill exercise—evidences revealed by the rat model

BMC Urology ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Kuan-Chou Chen ◽  
Shian-Ying Sung ◽  
Yi-Ting Lin ◽  
Chiu-Lan Hsieh ◽  
Kun-Hung Shen ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Rat Model ◽  
Treadmill Exercise ◽  
Prostatic Hyperplasia

Effect of 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid on the intraurethral pressure in a rat model of benign prostatic hyperplasia

2015 ◽  
Vol 23 (3) ◽  
pp. 259-265 ◽  
Author(s):  
Bo Ram Choi ◽  
Kiran Kumar Soni ◽  
Li Tao Zhang ◽  
Sung Won Lee ◽  
Insuk So ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Carboxylic Acid ◽  
Rat Model ◽  
Prostatic Hyperplasia

scholarly journals Effect of Paecilomyces tenuipes Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Sprague–Dawley Rats

2019 ◽  
Vol 16 (19) ◽  
pp. 3764 ◽  
Author(s):  
Choi ◽  
Kim ◽  
Fan ◽  
Tang ◽  
Hwang ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Rat Model ◽  
Testosterone Propionate ◽  
Inhibitory Effect ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Lncap Cells ◽  
Prostate Cell ◽  
Expression Levels ◽  
Prostate Size

: Benign prostatic hyperplasia (BPH) is one of the major public health concerns, which has a high prevalence rate and causes significant decline in men's quality of life. BPH is highly related to sexual hormone metabolism and aging. In particular, dihydrotestosterone (DHT), to which testosterone is modified by 5α-reductase (5AR), has a significant effect on BPH development. DHT binds to an androgen receptor (AR) and steroid receptor coactivator 1 (SRC-1); then, it induces the proliferation of a prostate cell and expression of prostate specific antigen (PSA). Paecilomyces tenuipes (P. tenuipes) is a mushroom that has been popularized by the artificial cultivation of fruiting bodies based on silkworms by researchers from the Republic of Korea. In a previous study, we identified the effect of PE on PSA mRNA expression in LNCaP cells. This suggests that PE may have an inhibitory effect on androgen signaling. Therefore, we confirmed the expression of androgen signaling-related factors, such as AR, SRC-1, and PSA in LNCaP. Furthermore, we confirmed the androgen signaling inhibitory effect of PE using the testosterone propionate (TP)-induced BPH rat model. A BPH rat model was established with a four-week treatment of daily subcutaneous injections of testosterone propionate (TP, 3 mg/kg) dissolved in corn oil after castration. The rats in the treatment group were orally gavaged P. tenuipes extract (PE), finasteride (Fi), or saw palmetto extract (Saw) with TP injection. DHT induced an increase in the expression levels of AR, SRC-1, and PSA proteins in LNCaP cells. On the contrary, the PE treatment reduced the expression levels. In vivo, the BPH group showed an increase in prostate size compared with the control group. The PE gavaged group showed a decrease in prostate size compared with the BPH group. In addition, the protein expressions of AR, 5AR2, and PSA were significantly lower in the PE gavaged group than BPH group in prostate tissue. These results suggest the beneficial effects of PE on BPH via the modulation of AR signaling pathway.

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