Spike synchrony modulated by membrane properties in a network model of globus pallidus externus

2009 ◽  
Vol 65 ◽  
pp. S169
Author(s):  
Tomohiro Fujita ◽  
Katsunori Kitano
Keyword(s):  
Globus Pallidus ◽  
Network Model ◽  
Membrane Properties ◽  
Spike Synchrony ◽  
Globus Pallidus Externus

scholarly journals Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo

2020 ◽  
Author(s):  
Maya Ketzef ◽  
Gilad Silberberg
Keyword(s):  
Globus Pallidus ◽  
Synaptic Input ◽  
Membrane Properties ◽  
Projection Neurons ◽  
Inhibitory Input ◽  
Indirect Pathway ◽  
Functional Roles ◽  
Striatal Projection Neurons ◽  
Afferent Inputs

SummaryThe rodent external Globus Pallidus (GPe) contains two main neuronal subpopulations, prototypic and arkypallidal cells, which differ in their cellular properties. Their functional synaptic connectivity is, however, largely unknown. Here, we studied the membrane properties and synaptic inputs to these subpopulations in the mouse GPe. We obtained in vivo whole-cell recordings from identified GPe neurons and used optogenetic stimulation to dissect their afferent inputs from the striatum and subthalamic nucleus (STN). All GPe neurons received barrages of excitatory and inhibitory input during slow wave activity. The modulation of their activity was cell-type specific and shaped by their respective membrane properties and afferent inputs. Both GPe subpopulations received synaptic input from STN and striatal projection neurons (MSNs). STN and indirect pathway MSNs strongly targeted prototypic cells while direct pathway MSNs selectively inhibited arkypallidal cells. We show that GPe subtypes are differently embedded in the basal ganglia network, supporting distinct functional roles.

scholarly journals 0166 MOVEMENT IMPAIRMENT AND SLEEP DISORDER CAUSED BY BILATERAL GLOBUS PALLIDUS EXTERNUS (GPE) INJECTION OF COPPER IN RATS

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A62-A62
Author(s):  
X Yang ◽  
F Qi ◽  
W Yang ◽  
C Guo ◽  
S Zhan ◽  
...  
Keyword(s):  
Sleep Disorder ◽  
Globus Pallidus ◽  
Globus Pallidus Externus

Lesions in monkey globus pallidus externus exacerbate parkinsonian symptoms

2006 ◽  
Vol 199 (2) ◽  
pp. 446-453 ◽  
Author(s):  
Jianyu Zhang ◽  
Gary S. Russo ◽  
Klaus Mewes ◽  
David B. Rye ◽  
Jerrold L. Vitek
Keyword(s):  
Globus Pallidus ◽  
Globus Pallidus Externus
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