A Synaptotoxic Pathway from Aβ oligomer to Prion Protein to mGluR5 to F kinase in Alzheimer's Disease

2014 ◽  
Vol 35 ◽  
pp. S21 ◽  
Author(s):  
Stephen Strittmatter ◽  
M. Kostylev ◽  
A.C. Kaufman ◽  
L. Haas ◽  
J.K. Heiss ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Aβ Oligomer

F5-02-03: Targeting Aβ oligomer formation in Alzheimer's disease: Challenges and alternatives to oligomer-specific therapeutic avenues

2015 ◽  
Vol 11 (7S_Part_6) ◽  
pp. P305-P305
Author(s):  
Timothy M. Ryan ◽  
Blaine R. Roberts ◽  
Gawain McColl ◽  
Dominic J. Hare ◽  
Mark G. Hinds ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oligomer Formation ◽  
Aβ Oligomer

[P2-143]: SCREENING FOR INHIBITORS OF APOE4-CATALYZED Aβ OLIGOMER/FILAMENT FORMATION: A NOVEL APPROACH TO ALZHEIMER's DISEASE DRUG DISCOVERY

2017 ◽  
Vol 13 (7S_Part_13) ◽  
pp. P662-P663
Author(s):  
Christina M. Coughlan ◽  
Athena Wang ◽  
Lisa Viltz ◽  
Heidi J. Chial ◽  
Huntington Potter
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Filament Formation ◽  
Novel Approach ◽  
Aβ Oligomer

scholarly journals Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in aDrosophilamodel of Alzheimer's disease

2018 ◽  
Vol 293 (34) ◽  
pp. 13090-13099 ◽  
Author(s):  
Nadine D. Younan ◽  
Ko-Fan Chen ◽  
Ruth-Sarah Rose ◽  
Damian C. Crowther ◽  
John H. Viles
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Amyloid Β ◽  
Aβ Oligomers

Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain

2010 ◽  
Vol 31 (3) ◽  
pp. 208-214 ◽  
Author(s):  
Reisuke H. Takahashi ◽  
Minoru Tobiume ◽  
Yuko Sato ◽  
Tetsutaro Sata ◽  
Gunnar K. Gouras ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Amyloid Plaques ◽  
Cellular Prion Protein ◽  
Dystrophic Neurites

scholarly journals No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population

2006 ◽  
Vol 38 (6) ◽  
pp. 727-731 ◽  
Author(s):  
Kyungsook Ahn ◽  
Eunkyung Kim ◽  
Young-A Kwon ◽  
Doh Kwan Kim ◽  
Jong-Eun Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Korean Population ◽  
Prion Protein Gene

scholarly journals The bile acid TUDCA improves glucose homeostasis through increase of insulin levels in mice with Alzheimer's disease

2019 ◽  
Author(s):  
Lucas Zangerolamo ◽  
Helena Cristina de Lima Barbosa Sampaio ◽  
Jean Franciesco Vettorazzi ◽  
Carina Solon ◽  
Gabriela Moreira Soares ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Bile Acid ◽  
Elderly Population ◽  
Population Studies ◽  
The Elderly ◽  
Insulin Homeostasis ◽  
Aβ Oligomer

Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most prevalent disorders in the elderly population. Studies suggest that people with T2DM have higher risk of developing AD. Likewise, AD brains presents Insulin resistance resulting in low capacity of glucose uptake. There is a growing evidence that insulin resistance and downstream abnormalities in the insulin signaling pathway are present in the AD brain and contribute to the development of cognitive dysfunction. Here we reported that C57BL/6 mice submitted to intracerebroventricular injection of streptozotocin, model of AD, and treated during 10 days with the bile acid TUDCA presented reduced accumulation of Aβ oligomer in the hippocampus and higher insulin secretion and glucose tolerance, besides improvement in memory test, suggesting that TUDCA treatment interferes with glucose-insulin homeostasis in brain and consequently attenuates AD.

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