scholarly journals Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques

NeuroImage ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 2284-2297 ◽  
Author(s):  
Karla L. Miller ◽  
Jennifer A. McNab ◽  
Saad Jbabdi ◽  
Gwenaëlle Douaud
2012 ◽  
Vol 68 (5) ◽  
pp. 1527-1535 ◽  
Author(s):  
Giovanna S. Danagoulian ◽  
Lei Qin ◽  
Krishna S. Nayak ◽  
Rivka R. Colen ◽  
Srinivasan Mukundan ◽  
...  

Author(s):  
Patrick Krumm ◽  
Petros Martirosian ◽  
Dominik Rath ◽  
Meinrad Gawaz ◽  
Konstantin Nikolaou ◽  
...  

Purpose To compare true positive and false negative results of myocardial edema mapping in two methods. Myocardial edema may be difficult to detect on cardiac MRI. Materials and Methods 76 patients (age 59 ± 11 years, 15 female) with acute myocardial infarction (MI) and 10 healthy volunteers were prospectively included in this single-center study. 1.5 T cardiac MRI was performed in patients 2.5 days after revascularization (median) for edema mapping: Steady State Free Precession (SSFP) mapping sequence with T2-preparation pulses (T2prep); and dual-contrast Fast Spin-Echo (dcFSE) signal decay edema mapping. Late gadolinium enhancement (LGE) was used as the reference for expected edema in acute MI. Results 311 myocardial segments in patients were acutely infarcted with mean T2 73 ms for T2prep SSFP vs. 87 ms for dcFSE edema mapping. In healthy volunteers the mean T2 was 56 ms for T2prep SSFP vs. 50 ms for dcFSE edema mapping. Receiver operating characteristic (ROC) curve for T2prep SSFP show area under the curve (AUC) 0.962, p < 0.0001, Youden index J 0.8266, associated criterion > 60 ms, sensitivity 94 %, specificity 89 %. dcFSE ROC AUC 0.979, p < 0.0001, J 0.9219, associated criterion > 64 ms, sensitivity 93 %, specificity 99 %. Conclusion Both edema mapping methods indicate high-grade edema with high sensitivity. Nevertheless, edema in acute infarction may be focally underestimated in both mapping methods. Key Points:  Citation Format


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