Direct visualization of cerebellar nuclei in patients with focal cerebellar lesions and its application for lesion-symptom mapping

NeuroImage ◽  
2012 ◽  
Vol 63 (3) ◽  
pp. 1421-1431 ◽  
Author(s):  
S. Maderwald ◽  
M. Thürling ◽  
M. Küper ◽  
N. Theysohn ◽  
O. Müller ◽  
...  
Keyword(s):  
Cerebellar Nuclei ◽  
Direct Visualization ◽  
Cerebellar Lesions ◽  
Lesion Symptom Mapping

scholarly journals Mapping of long-term cognitive and motor deficits in pediatric cerebellar brain tumor survivors into a cerebellar white matter atlas

2021 ◽  
Author(s):  
Frederik Grosse ◽  
Stefan Mark Rueckriegel ◽  
Ulrich-Wilhelm Thomale ◽  
Pablo Hernáiz Driever
Keyword(s):  
Brain Tumor ◽  
Executive Function ◽  
Cognitive Function ◽  
White Matter ◽  
Cerebellar Nuclei ◽  
Motor Deficits ◽  
Deep Cerebellar Nuclei ◽  
Cerebellar White Matter ◽  
Lesion Symptom Mapping

Abstract Purpose Diaschisis of cerebrocerebellar loops contributes to cognitive and motor deficits in pediatric cerebellar brain tumor survivors. We used a cerebellar white matter atlas and hypothesized that lesion symptom mapping may reveal the critical lesions of cerebellar tracts. Methods We examined 31 long-term survivors of pediatric posterior fossa tumors (13 pilocytic astrocytoma, 18 medulloblastoma). Patients underwent neuronal imaging, examination for ataxia, fine motor and cognitive function, planning abilities, and executive function. Individual consolidated cerebellar lesions were drawn manually onto patients’ individual MRI and normalized into Montreal Neurologic Institute (MNI) space for further analysis with voxel-based lesion symptom mapping. Results Lesion symptom mapping linked deficits of motor function to the superior cerebellar peduncle (SCP), deep cerebellar nuclei (interposed nucleus (IN), fastigial nucleus (FN), ventromedial dentate nucleus (DN)), and inferior vermis (VIIIa, VIIIb, IX, X). Statistical maps of deficits of intelligence and executive function mapped with minor variations to the same cerebellar structures. Conclusion We identified lesions to the SCP next to deep cerebellar nuclei as critical for limiting both motor and cognitive function in pediatric cerebellar tumor survivors. Future strategies safeguarding motor and cognitive function will have to identify patients preoperatively at risk for damage to these critical structures and adapt multimodal therapeutic options accordingly.

Direct visualization of phase-separated domains in lipid membranes

1978 ◽  
Vol 36 (2) ◽  
pp. 290-291
Author(s):  
S. W. Hui ◽  
T. P. Stewart
Keyword(s):  
Lipid Membranes ◽  
Structural Information ◽  
Freeze Fracture ◽  
Biological Molecules ◽  
Vacuum Drying ◽  
Direct Visualization ◽  
X Ray Diffraction ◽  
Electron Microscopic ◽  
X Ray ◽  
Hydrocarbon Chains

Direct electron microscopic study of biological molecules has been hampered by such factors as radiation damage, lack of contrast and vacuum drying. In certain cases, however, the difficulties may be overcome by using redundent structural information from repeating units and by various specimen preservation methods. With bilayers of phospholipids in which both the solid and fluid phases co-exist, the ordering of the hydrocarbon chains may be utilized to form diffraction contrast images. Domains of different molecular packings may be recgnizable by placing properly chosen filters in the diffraction plane. These domains would correspond to those observed by freeze fracture, if certain distinctive undulating patterns are associated with certain molecular packing, as suggested by X-ray diffraction studies. By using an environmental stage, we were able to directly observe these domains in bilayers of mixed phospholipids at various temperatures at which their phases change from misible to inmissible states.

964: Direct Visualization of Renal Hemodyanamics Affected by Carbon Dioxide Pneumoperitoneum

2007 ◽  
Vol 177 (4S) ◽  
pp. 319-319
Author(s):  
Naoto Sassa ◽  
Ryohei Hattori ◽  
Yoshinari Ono ◽  
Tokunori Yamamoto ◽  
Momokazu Gotoh
Keyword(s):  
Carbon Dioxide ◽  
Direct Visualization ◽  
Carbon Dioxide Pneumoperitoneum

1615: Direct Visualization of Cortical Peritubular Capillary in Human Transplanted Kidney after Reperfusion Injury Using Magnifying Endoscopy

2005 ◽  
Vol 173 (4S) ◽  
pp. 437-438
Author(s):  
Masashi Kato ◽  
Ryohei Hattori ◽  
Tokunori Yamamoto ◽  
Minako Hagikura ◽  
Yoshinari Ono
Keyword(s):  
Reperfusion Injury ◽  
Magnifying Endoscopy ◽  
Direct Visualization ◽  
Peritubular Capillary ◽  
Transplanted Kidney

Evaluation of multiple-session eyeblink conditioning comparing patients with focal cerebellar lesions and cerebellar degeneration

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
M Gerwig ◽  
H Guberina ◽  
A.C Eßer ◽  
A Floßdorf ◽  
B Schoch ◽  
...  
Keyword(s):  
Eyeblink Conditioning ◽  
Cerebellar Degeneration ◽  
Cerebellar Lesions

Anatomical correlate of smooth pursuit deficit in patients with cerebellar lesions

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
B Baier ◽  
P Stoeter ◽  
M Dieterich
Keyword(s):  
Smooth Pursuit ◽  
Cerebellar Lesions

Direct Visualization of A2, A3, and A4 Finger Flexor Pulley Injuries at 3-T and 7-T MRI: An Ex Vivo Study

2020 ◽  
Author(s):  
Rafael Heiss ◽  
Frank W. Roemer ◽  
Christoph Lutter ◽  
Rolf Janka ◽  
Volker Schöffl ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Direct Visualization ◽  
Ex Vivo Study

Direct visualization of the microcirculation during clinical hypothermic circulatory arrest

2005 ◽  
Vol 53 (S 01) ◽  
Author(s):  
M Kamler ◽  
V Milekhin ◽  
N Pizanis ◽  
I Wiese ◽  
U Herold ◽  
...  
Keyword(s):  
Circulatory Arrest ◽  
Hypothermic Circulatory Arrest ◽  
Direct Visualization
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