Voxel-based lesion symptom mapping analysis for dysphagia in stroke patients with isolated cerebellar lesions

2021 ◽  
Author(s):  
Hyun Im Moon ◽  
Yoon Jeong Jeong ◽  
Ji Hyun Suh
Keyword(s):  
Stroke Patients ◽  
Mapping Analysis ◽  
Cerebellar Lesions ◽  
Lesion Symptom Mapping

scholarly journals Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping

2021 ◽  
Author(s):  
Selma Lugtmeijer ◽  
◽  
Linda Geerligs ◽  
Frank Erik de Leeuw ◽  
Edward H. F. de Haan ◽  
...  
Keyword(s):  
Working Memory ◽  
Episodic Memory ◽  
Visual Working Memory ◽  
Visual Memory ◽  
Right Hemisphere ◽  
Memory Task ◽  
Stroke Patients ◽  
Lesion Symptom Mapping ◽  
Criterion Setting ◽  
The Right

AbstractWorking memory and episodic memory are two different processes, although the nature of their interrelationship is debated. As these processes are predominantly studied in isolation, it is unclear whether they crucially rely on different neural substrates. To obtain more insight in this, 81 adults with sub-acute ischemic stroke and 29 elderly controls were assessed on a visual working memory task, followed by a surprise subsequent memory test for the same stimuli. Multivariate, atlas- and track-based lesion-symptom mapping (LSM) analyses were performed to identify anatomical correlates of visual memory. Behavioral results gave moderate evidence for independence between discriminability in working memory and subsequent memory, and strong evidence for a correlation in response bias on the two tasks in stroke patients. LSM analyses suggested there might be independent regions associated with working memory and episodic memory. Lesions in the right arcuate fasciculus were more strongly associated with discriminability in working memory than in subsequent memory, while lesions in the frontal operculum in the right hemisphere were more strongly associated with criterion setting in subsequent memory. These findings support the view that some processes involved in working memory and episodic memory rely on separate mechanisms, while acknowledging that there might also be shared processes.

A voxel-based lesion symptom mapping analysis of chronic pain in multiple sclerosis

2020 ◽  
Author(s):  
Domenico Plantone ◽  
Catello Vollono ◽  
Matteo Pardini ◽  
Guido Primiano ◽  
Virxhina Myftari ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Chronic Pain ◽  
Mapping Analysis ◽  
Lesion Symptom Mapping

scholarly journals Componential Network for the Recognition of Tool-Associated Actions: Evidence from Voxel-based Lesion-Symptom Mapping in Acute Stroke Patients

2016 ◽  
Author(s):  
Markus Martin ◽  
Andrea Dressing ◽  
Tobias Bormann ◽  
Charlotte S. M. Schmidt ◽  
Dorothee Kümmerer ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Stroke Patients ◽  
Lesion Symptom Mapping

Neural Correlates of Hiccups in Patients with Lateral Medullary Infarction

2021 ◽  
pp. 097275312110237
Author(s):  
Appaswamy Thirumal Prabhakar ◽  
Tephilah Rabi ◽  
Atif I. A. Shaikh ◽  
Sanjith Aaron ◽  
Rohit Benjamin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Neural Correlates ◽  
Permutation Testing ◽  
Resonance Imaging ◽  
Lateral Medullary Infarction ◽  
Lateral Region ◽  
Mapping Analysis ◽  
Lesion Symptom Mapping ◽  
The Brain ◽  
Medullary Infarction

Background Hiccups is a known presentation of lateral medullary infarction. However, the region in the medulla associated with this finding is not clearly known. In this study, we aimed to study the neural correlates of hiccups in patients with lateral medullary infarction (LMI). Materials and Methods This retrospective study included all patients who presented with lateral medullary infarction between January 2008 and May 2018. Patients with hiccups following LMI were identified as cases and those with no hiccups but who had LMI were taken as controls. The magnetic resonance imaging of the brain was done viewed and individual lesions were mapped manually to the template brain. Voxel-based lesion-symptom mapping employing nonparametric permutation testing was performed using MRIcron. Results There were a total of 31 patients with LMI who presented to the hospital during the study period. There were 11 (35.5%) patients with hiccups. Using the voxel-based lesion-symptom mapping analysis, the dorso-lateral region of the middle medulla showed significant association with hiccups. Conclusion In patients with LMI, we postulate that damage to the dorsolateral aspect on the middle medulla could result in hiccups.

Direct visualization of cerebellar nuclei in patients with focal cerebellar lesions and its application for lesion-symptom mapping

NeuroImage ◽  
2012 ◽  
Vol 63 (3) ◽  
pp. 1421-1431 ◽  
Author(s):  
S. Maderwald ◽  
M. Thürling ◽  
M. Küper ◽  
N. Theysohn ◽  
O. Müller ◽  
...  
Keyword(s):  
Cerebellar Nuclei ◽  
Direct Visualization ◽  
Cerebellar Lesions ◽  
Lesion Symptom Mapping

Timing Matters? Learning of Complex Spatiotemporal Sequences in Left-hemisphere Stroke Patients

2016 ◽  
Vol 28 (2) ◽  
pp. 223-236 ◽  
Author(s):  
Anna Dovern ◽  
Gereon R. Fink ◽  
David C. Timpert ◽  
Jochen Saliger ◽  
Hans Karbe ◽  
...  
Keyword(s):  
Left Hemisphere ◽  
Sequence Learning ◽  
Spatial Information ◽  
Critical Role ◽  
Sequence Information ◽  
Motor Sequence Learning ◽  
Motor Sequence ◽  
Stroke Patients ◽  
Implicit Timing ◽  
Lesion Symptom Mapping

During rehabilitation after stroke motor sequence learning is of particular importance because considerable effort is devoted to (re)acquiring lost motor skills. Previous studies suggest that implicit motor sequence learning is preserved in stroke patients but were restricted to the spatial dimension, although the timing of single action components is as important as their spatial order. As the left parietal cortex is known to play a critical role in implicit timing and spatiotemporal integration, in this study we applied an adapted version of the SRT task designed to assess both spatial (different stimulus locations) and temporal (different response–stimulus intervals) aspects of motor learning to 24 right-handed patients with a single left-hemisphere (LH) stroke and 24 age-matched healthy controls. Implicit retrieval of sequence knowledge was tested both at Day 1 and after 24 hr (Day 2). Additionally, voxel-based lesion symptom mapping was used to investigate the neurobiological substrates of the behavioral effects. Although LH stroke patients showed a combined spatiotemporal learning effect that was comparable to that observed in controls, LH stroke patients did not show learning effects for the learning probes in which only one type of sequence information was maintained whereas the other one was randomized. Particularly on Day 2, patients showed significantly smaller learning scores for these two learning probes than controls. Voxel-based lesion symptom mapping analyses revealed for all learning probes that diminished learning scores on Day 2 were associated with lesions of the striatum. This might be attributed to its role in motor chunking and offline consolidation as group differences occurred on Day 2 only. The current results suggest that LH stroke patients rely on multimodal information (here: temporal and spatial information) when retrieving motor sequence knowledge and are very sensitive to any disruption of the learnt sequence information as they seem to build very rigid chunks preventing them from forming independent spatial and temporal sequence representations.

When “Crack walnuts” lies in different brain regions: Evidence from a voxel-based lesion-symptom mapping study

2010 ◽  
Vol 16 (3) ◽  
pp. 433-442 ◽  
Author(s):  
FABRIZIO PIRAS ◽  
PAOLA MARANGOLO
Keyword(s):  
Lexical Processing ◽  
Brain Regions ◽  
Cognitive Mechanisms ◽  
Mapping Study ◽  
Stroke Patients ◽  
Dual Route ◽  
Lesion Symptom Mapping ◽  
Complex Words ◽  
Naming Tasks ◽  
The Brain

AbstractTheories of lexical processing differ as to how multimorphemic words, such as compounds, are mentally processed. The most recent findings seem to support the dual route hypothesis, which assumes that complex words can be stored and retrieved either whole or by decomposition into their constituents. Despite great efforts to investigate the cognitive mechanisms involved in processing complex words, very little is known about how compounds are represented in the brain. The present study was designed to address this issue in a group of 20 left-hemispheric stroke patients who were submitted to four picture-naming tasks involving nouns, verbs, noun-noun (NN) and verb-noun (VN) compounds. To determine the brain lesions implicated in these tasks, we analyzed patients’ performances together with their lesions using Voxel-based Lesion Symptom Mapping (VLSM). Results showed that while NN involved the same temporal areas as nouns, VN (although they belong to the noun category) involved different fronto-temporal regions. This latter finding is discussed within the view that distinct mechanisms process the different constituents of complex words. (JINS, 2010, 16, 433–442.)

Visual neglect after left-hemispheric lesions: a voxel-based lesion–symptom mapping study in 121 acute stroke patients

2016 ◽  
Vol 235 (1) ◽  
pp. 83-95 ◽  
Author(s):  
Lena-Alexandra Beume ◽  
Markus Martin ◽  
Christoph P. Kaller ◽  
Stefan Klöppel ◽  
Charlotte S. M. Schmidt ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Mapping Study ◽  
Visual Neglect ◽  
Stroke Patients ◽  
Lesion Symptom Mapping

scholarly journals Characterising factors underlying praxis deficits in chronic left hemisphere stroke patients

2020 ◽  
Author(s):  
Elisabeth Rounis ◽  
Ajay Halai ◽  
Gloria Pizzamiglio ◽  
Matthew A. Lambon Ralph
Keyword(s):  
Left Hemisphere ◽  
Cognitive Disorders ◽  
Principal Component ◽  
Lesion Volume ◽  
Semantic Retrieval ◽  
Stroke Patients ◽  
Limb Apraxia ◽  
Lesion Symptom Mapping ◽  
Neuropsychological Tasks ◽  
Left Hemisphere Stroke

AbstractLimb apraxia, a disorder of skilled action not consequent on primary motor or sensory deficits, has traditionally been defined according to errors patients make on neuropsychological tasks. Previous models of the disorder have failed to provide a unified account of patients’ deficits, due to heterogeneity in the patients and tasks used. In this study we implemented principal component analysis (PCA) to elucidate core factors of the disorder in a cohort of 41 unselected left hemisphere chronic stroke patients who were tested on a comprehensive and validated apraxia screen. Three principal components were identified: posture selection, semantic control and multi-demand sequencing. These were submitted to a lesion symptom mapping (VBCM) analysis in a subset of 24 patients, controlled for lesion volume, age and time post-stroke. Although the first component revealed no significant structural correlates, the second and third components were related to regions in the ‘ventro-dorsal’ and ‘ventral’ and ‘dorsal’ pathways, respectively. These results challenge the previously reported distinction between ideomotor and ideational deficits and highlight a significant role of common cognitive functions in the disorder, which include action selection, semantic retrieval, sequencing and response inhibition. Further research using this technique would help elucidate the cognitive processes underlying limb apraxia and their relationship with other cognitive disorders.

scholarly journals Disconnection somewhere down the line: Multivariate lesion-symptom mapping of the line bisection error

2020 ◽  
Author(s):  
Daniel Wiesen ◽  
Hans-Otto Karnath ◽  
Christoph Sperber
Keyword(s):  
Line Bisection ◽  
Angular Gyrus ◽  
Support Vector ◽  
Focal Lesion ◽  
Stroke Patients ◽  
Bisection Task ◽  
Anatomical Basis ◽  
Lesion Symptom Mapping ◽  
The Right ◽  
Line Bisection Task

AbstractLine Bisection is a simple task frequently used in stroke patients to diagnose disorders of spatial perception characterized by a directional bisection bias to the ipsilesional side. However, previous anatomical and behavioural findings are contradictory, and the diagnostic validity of the line bisection task has been challenged. We hereby aimed to re-analyse the anatomical basis of pathological line bisection by using multivariate lesion-symptom mapping and disconnection-symptom mapping based on support vector regression in a sample of 163 right hemispheric acute stroke patients. In line with some previous studies, we observed that pathological line bisection was related to more than a single focal lesion location. Cortical damage primarily to right parietal areas, particularly the inferior parietal lobe, including the angular gyrus, as well as damage to the right basal ganglia contributed to the pathology. In contrast to some previous studies, an involvement of frontal cortical brain areas in the line bisection task was not observed. Subcortically, damage to the right superior longitudinal fasciculus (I, II and III) and arcuate fasciculus as well as the internal capsule was associated with line bisection errors. Moreover, white matter damage of interhemispheric fibre bundles, such as the anterior commissure and posterior parts of the corpus callosum projecting into the left hemisphere, was predictive of pathological deviation in the line bisection task.

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