Acute Varicella-Zoster Virus meningitis in a multiple sclerosis patient treated with fingolimod

We discuss a case of presumed bilateral herpes simplex keratouveitis in a 36-year-old multiple sclerosis patient switched to fingolimod from glatiramer acetate. Fingolimod treatment appears to increase the risk of herpesvirus infections, including with herpes simplex virus and varicella zoster virus. This case report reviews the potential immunology behind this risk, and identifies the need for further research, including ways to minimize and stratify risk for herpesvirus reactivation.

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Antigen-shift in varicella-zoster virus-specific T-cell immunity over the course of Fingolimod-treatment in relapse-remitting multiple sclerosis patients

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2019.101859 ◽

2020 ◽

Vol 38 ◽

pp. 101859 ◽

Cited By ~ 1

Author(s):

Sarah Matko ◽

Katja Akgün ◽

Torsten Tonn ◽

Tjalf Ziemssen ◽

Marcus Odendahl

Keyword(s):

Multiple Sclerosis ◽

T Cell ◽

Varicella Zoster Virus ◽

T Cell Immunity ◽

Varicella Zoster ◽

Cell Immunity ◽

Remitting Multiple Sclerosis ◽

Multiple Sclerosis Patients

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Varicella zoster immunity loss in multiple sclerosis patient treated with ocrelizumab

Clinical Immunology ◽

10.1016/j.clim.2020.108554 ◽

2020 ◽

pp. 108554

Author(s):

L. Rapisarda ◽

P. Valentino ◽

S. Barone ◽

C. Torti ◽

V. La Gamba ◽

...

Keyword(s):

Multiple Sclerosis ◽

Multiple Sclerosis Patient ◽

Varicella Zoster

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Multiple sclerosis and varicella zoster virus infection: A review

Epidemiology and Infection ◽

10.1017/s0950268801005891 ◽

2001 ◽

Vol 127 (2) ◽

pp. 315-325 ◽

Cited By ~ 28

Author(s):

R. A. MARRIE ◽

C. WOLFSON

Keyword(s):

Multiple Sclerosis ◽

Varicella Zoster Virus ◽

Case Control ◽

Varicella Zoster Virus Infection ◽

Historical Cohort ◽

Large Variability ◽

Medline Search ◽

Varicella Zoster ◽

Increased Risk

We have evaluated the epidemiological evidence for an aetiological role of varicella zoster virus (VZV) infection in the development of multiple sclerosis (MS). A MEDLINE search of the English language literature for 1965–99 identified 40 studies. These studies were categorized as seroepidemiological (13), case-control (23), historical cohort (2) or ecological (2). One study used both case-control and historical cohort methodologies. Studies were then classified according to methodological rigour, using criteria derived from published guidelines for the epidemiological study of MS. There was a large variability in the quality of evidence. The five studies with the best methodology failed to show an increased risk of MS associated with varicella or zoster infections. At the present time there is insufficient evidence to support an important aetiological role of VZV infection in the development of MS.

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