Physicochemical Stability Study of the Morphine-Ropivacaine-Ziconotide Association in Implantable Pumps for Intrathecal Administration

2022 ◽  
Author(s):  
Julien Robert ◽  
Jérémy Sorrieul ◽  
Denis Dupoiron ◽  
Sabrina Jubier-Hamon ◽  
Florent Bienfait ◽  
...  
Keyword(s):  
Intrathecal Administration ◽  
Stability Study ◽  
Physicochemical Stability

scholarly journals Validation of an HPLC Assay Method for Routine QC Testing and Stability Study of Compounded Low-Dose Capsules of Acetylsalicylic Acid

2018 ◽  
Vol 3 (4) ◽  
pp. 199-206
Author(s):  
Nelly Lonca ◽  
Fabienne Maillard ◽  
Géraldine Leguelinel ◽  
Tahmer Sharkawi ◽  
Ian Soulairol
Keyword(s):  
Acetylsalicylic Acid ◽  
Orthophosphoric Acid ◽  
Low Dose ◽  
Stability Study ◽  
Assay Method ◽  
Stability Studies ◽  
Physicochemical Stability ◽  
Hospital Pharmacies ◽  
Provocation Testing ◽  
Low Dosage

Abstract Background The intolerance to Acetylsalicylic Acid (ASA) can be detected by conducting oral provocation testing (OPT), which is to gradually introduce low doses of ASA. To perform this test, hospital pharmacies compound small batches of different low-dosage ASA capsules. This work aims to validate a method for fast HPLC-UV assay that allows routine quality control and physicochemical stability studies of capsules. Methods The chromatographic separation is performed using a C18 column Kinetex (100 A, 50×4.6 mm, 2.6 µm) equipped with a precolumn C18. Separation is achieved using a mobile phase composed of water-acetonitrile-orthophosphoric acid (68:32:0.2 v/v/v) at a flow rate of 0.8 mL/min and UV detection at 237 nm. Results Validation shows that the method was suitable for routine analysis and could be used to perform stability studies. Conclusions The 5, 25, 100 and 250 mg dosed capsules show acceptable stability over 12 months, while the 1 mg dosed capsule show an unacceptable degradation of more than 15 % after 3 months. Therefore, hospital pharmacy can plan the manufacture of capsules and anticipate the requests of doctors.

scholarly journals Physicochemical Stability Study on Cyclosporine A Loaded Dry-Emulsion Formulation with Enhanced Solubility

2015 ◽  
Vol 63 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Hideyuki Sato ◽  
Kumiko Ogawa ◽  
Yoshiki Kojo ◽  
Hiroki Suzuki ◽  
Takahiro Mizumoto ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Stability Study ◽  
Physicochemical Stability ◽  
Enhanced Solubility ◽  
Emulsion Formulation ◽  
Dry Emulsion

Physicochemical Stability Study of Polymyxin B in Various Infusion Solutions for Administration to Critically Ill Patients

2016 ◽  
Vol 50 (9) ◽  
pp. 790-792 ◽  
Author(s):  
Tze-Peng Lim ◽  
Daryl Kim-Hor Hee ◽  
Winnie Lee ◽  
Jocelyn Qi-Min Teo ◽  
Yiying Cai ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Polymyxin B ◽  
Stability Study ◽  
Physicochemical Stability

Physicochemical stability study of protein–benzoic acid complexes using molecular dynamics simulations

Amino Acids ◽  
2020 ◽  
Vol 52 (9) ◽  
pp. 1353-1362
Author(s):  
Mahreen Arooj ◽  
Ihsan Shehadi ◽  
Chahlaa N. Nassab ◽  
Ahmed A. Mohamed
Keyword(s):  
Molecular Dynamics ◽  
Benzoic Acid ◽  
Molecular Dynamics Simulations ◽  
Stability Study ◽  
Physicochemical Stability ◽  
Dynamics Simulations

Physicochemical stability study of a new Trimix formulation for treatment of erectile dysfunction

2013 ◽  
Vol 71 (5) ◽  
pp. 358-363 ◽  
Author(s):  
V. Vieillard ◽  
N. Eychenne ◽  
A. Astier ◽  
R. Yiou ◽  
C. Deffaux ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Stability Study ◽  
Physicochemical Stability

Bupivacaine (S75:R25) Loaded in Nanostructured Lipid Carriers: Factorial Design, HPLC Quantification Method and Physicochemical Stability Study

2018 ◽  
Vol 15 (3) ◽  
pp. 388-396 ◽  
Author(s):  
Gustavo Henrique Rodrigues Da Silva ◽  
Ligia Nunes de Morais Ribeiro ◽  
Viviane Aparecida Guilherme ◽  
Simone Ramos de Castro ◽  
Marcia Cristina Breitkreitz ◽  
...  
Keyword(s):  
Factorial Design ◽  
Stability Study ◽  
Nanostructured Lipid Carriers ◽  
Quantification Method ◽  
Physicochemical Stability
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