Defining the evolutionary and gene regulatory logic of vertebrate neuronal diversity

Neuron ◽  
2022 ◽  
Vol 110 (1) ◽  
pp. 3-5
Author(s):  
Luis de la Torre-Ubieta
Keyword(s):  
Neuronal Diversity ◽  
Gene Regulatory

scholarly journals Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the prenatal human hypothalamus

2021 ◽  
Author(s):  
Brian Herb ◽  
Hannah J Glover ◽  
Aparna Bhaduri ◽  
Alex M Casella ◽  
Tracy L Bale ◽  
...  
Keyword(s):  
Developmental Trajectories ◽  
Single Cells ◽  
Neuronal Diversity ◽  
Cell Type ◽  
Human Hypothalamus ◽  
Paired Samples ◽  
Cell Type Specific ◽  
Gene Regulatory ◽  
Stem Cell Populations ◽  
Temporal Trajectory

The hypothalamus is critically important for regulating most autonomic, metabolic, and behavioral functions essential for life and species propagation, yet a comprehensive understanding of neuronal subtypes and their development in the human brain is lacking. Here, we characterized the prenatal human hypothalamus by sequencing the transcriptomes of 45,574 single-cells from 12 embryos, spanning gestational weeks 4 through 25. These cells describe a temporal trajectory from proliferative stem cell populations to maturing neurons and glia, including 38 distinct excitatory and inhibitory neuronal subtypes. Merging these data with paired samples from the cortex and ganglionic eminences (GE) revealed two distinct neurogenesis pathways, one shared between GE and hypothalamus and a second unique to cortex. Gene regulatory network modeling predicted that these distinct maturation trajectories involve the activation of region- and cell type-specific transcription factor networks. These results provide the first comprehensive transcriptomic view of human hypothalamus development at cellular resolution.

How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?

2020 ◽  
Vol 48 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Alyson Ashe
Keyword(s):  
Histone Modifications ◽  
Molecular Mechanisms ◽  
Epigenetic Inheritance ◽  
Nematode Caenorhabditis Elegans ◽  
Histone Methyltransferases ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Recent Developments ◽  
Gene Regulatory

Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful in investigating the underlying molecular mechanisms of this phenomenon. In C. elegans and other animals, the modification of histone proteins has emerged as a potential carrier and effector of transgenerational epigenetic information. In this review, we explore the contribution of histone modifications to TEI in C. elegans. We describe the role of repressive histone marks, histone methyltransferases, and associated chromatin factors in heritable gene silencing, and discuss recent developments and unanswered questions in how these factors integrate with other known TEI mechanisms. We also review the transgenerational effects of the manipulation of histone modifications on germline health and longevity.

Myelin Gene Regulatory Factor Is a Critical Transcriptional Regulator Required for CNS Myelination

2009 ◽  
Vol 138 (1) ◽  
pp. 172-185
Author(s):  
Ben Emery ◽  
Dritan Agalliu ◽  
John D. Cahoy ◽  
Trent A. Watkins ◽  
Jason C. Dugas ◽  
...  
Keyword(s):  
Transcriptional Regulator ◽  
Regulatory Factor ◽  
Gene Regulatory ◽  
Cns Myelination ◽  
Myelin Gene

2061-P: Islet Single Cell Transcriptomes Reveal Cellular and Gene Regulatory Alterations in Type 2 Diabetes Pathogenesis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2061-P
Author(s):  
NATHAN LAWLOR ◽  
ROMY KURSAWE ◽  
MICHAEL L. STITZEL
Keyword(s):  
Type 2 Diabetes ◽  
Single Cell ◽  
Gene Regulatory
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