Homogenous glycine receptor expression in cortical plate neurons and cajal-retzius cells of neonatal rat cerebral cortex

Neuroscience ◽  
2004 ◽  
Vol 123 (3) ◽  
pp. 715-724 ◽  
Author(s):  
A Okabe ◽  
W Kilb ◽  
C Shimizu-Okabe ◽  
I.L Hanganu ◽  
A Fukuda ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Glycine Receptor ◽  
Receptor Expression ◽  
Neonatal Rat ◽  
Rat Cerebral Cortex ◽  
Cortical Plate ◽  
Retzius Cells

Depolarizing glycine responses in Cajal-Retzius cells of neonatal rat cerebral cortex

Neuroscience ◽  
2002 ◽  
Vol 112 (2) ◽  
pp. 299-307 ◽  
Author(s):  
W. Kilb ◽  
M. Ikeda ◽  
K. Uchida ◽  
A. Okabe ◽  
A. Fukuda ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Neonatal Rat ◽  
Rat Cerebral Cortex ◽  
Retzius Cells

Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain

Development ◽  
1998 ◽  
Vol 125 (18) ◽  
pp. 3719-3729 ◽  
Author(s):  
D.S. Rice ◽  
M. Sheldon ◽  
G. D'Arcangelo ◽  
K. Nakajima ◽  
D. Goldowitz ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Signaling Pathway ◽  
Developmental Process ◽  
Cortical Plate ◽  
Mammalian Brain ◽  
Granule Neurons ◽  
Adapter Protein ◽  
Cell Position ◽  
Neuronal Precursors ◽  
Retzius Cells

Mutation of either reelin (Reln) or disabled-1 (Dab1) results in widespread abnormalities in laminar structures throughout the brain and ataxia in reeler and scrambler mice. Both exhibit the same neuroanatomical defects, including cerebellar hypoplasia with Purkinje cell ectopia and disruption of neuronal layers in the cerebral cortex and hippocampus. Despite these phenotypic similarities, Reln and Dab1 have distinct molecular properties. Reln is a large extracellular protein secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. In contrast, Dab1 is a cytoplasmic protein which has properties of an adapter protein that functions in phosphorylation-dependent intracellular signal transduction. Here, we show that Dab1 participates in the same developmental process as Reln. In scrambler mice, neuronal precursors are unable to invade the preplate of the cerebral cortex and consequently, they do not align within the cortical plate. During development, cells expressing Dab1 are located next to those secreting Reln at critical stages of formation of the cerebral cortex, cerebellum and hippocampus, before the first abnormalities in cell position become apparent in either reeler or scrambler. In reeler, the major populations of displaced neurons contain elevated levels of Dab1 protein, although they express normal levels of Dab1 mRNA. This suggests that Dab1 accumulates in the absence of a Reln-evoked signal. Taken together, these results indicate that Dab1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain.

Cellular physiology of the neonatal rat cerebral cortex

2003 ◽  
Vol 60 (4) ◽  
pp. 345-353 ◽  
Author(s):  
Heiko J. Luhmann ◽  
Ileana Hanganu ◽  
Werner Kilb
Keyword(s):  
Cerebral Cortex ◽  
Neonatal Rat ◽  
Rat Cerebral Cortex ◽  
Cellular Physiology

Equivalent cell density in three areas of neonatal rat cerebral cortex

1994 ◽  
Vol 176 (1) ◽  
pp. 85-88 ◽  
Author(s):  
France Morin ◽  
Clermont Beaulieu
Keyword(s):  
Cerebral Cortex ◽  
Cell Density ◽  
Neonatal Rat ◽  
Rat Cerebral Cortex
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