Lithium blocks stress-induced changes in depressive-like behavior and hippocampal cell fate: The role of glycogen-synthase-kinase-3β

Neuroscience ◽  
2008 ◽  
Vol 152 (3) ◽  
pp. 656-669 ◽  
Author(s):  
R. Silva ◽  
A.R. Mesquita ◽  
J. Bessa ◽  
J.C. Sousa ◽  
I. Sotiropoulos ◽  
...  
Keyword(s):  
Cell Fate ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Hippocampal Cell ◽  
Induced Changes

scholarly journals The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism

1999 ◽  
Vol 274 (25) ◽  
pp. 17934-17940 ◽  
Author(s):  
Scott A. Summers ◽  
Aimee W. Kao ◽  
Aimee D. Kohn ◽  
Gillian S. Backus ◽  
Richard A. Roth ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β

scholarly journals Role of Glycogen Synthase Kinase-3β in Cardioprotection

2009 ◽  
Vol 104 (11) ◽  
pp. 1240-1252 ◽  
Author(s):  
Magdalena Juhaszova ◽  
Dmitry B. Zorov ◽  
Yael Yaniv ◽  
H. Bradley Nuss ◽  
Su Wang ◽  
...  
Keyword(s):  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β

The Role of Glycogen Synthase Kinase 3β in the Transformation of Epidermal Cells

2007 ◽  
Vol 67 (16) ◽  
pp. 7756-7764 ◽  
Author(s):  
Cuiling Ma ◽  
Jian Wang ◽  
Ying Gao ◽  
Tian-Wen Gao ◽  
Gang Chen ◽  
...  
Keyword(s):  
Glycogen Synthase ◽  
Epidermal Cells ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β

scholarly journals Glycogen Synthase Kinase-3 Is Required for EfficientDictyosteliumChemotaxis

2010 ◽  
Vol 21 (15) ◽  
pp. 2788-2796 ◽  
Author(s):  
Regina Teo ◽  
Kimberley J. Lewis ◽  
Josephine E. Forde ◽  
W. Jonathan Ryves ◽  
Jonathan V. Reddy ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Cell Fate ◽  
Glycogen Synthase ◽  
Cell Aggregation ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3 ◽  
Cell Fate Determination ◽  
Cell Signaling Pathways

Glycogen synthase kinase-3 (GSK3) is a highly conserved protein kinase that is involved in several important cell signaling pathways and is associated with a range of medical conditions. Previous studies indicated a major role of the Dictyostelium homologue of GSK3 (gskA) in cell fate determination during morphogenesis of the fruiting body; however, transcriptomic and proteomic studies have suggested that GSK3 regulates gene expression much earlier during Dictyostelium development. To investigate a potential earlier role of GskA, we examined the effects of loss of gskA on cell aggregation. We find that cells lacking gskA exhibit poor chemotaxis toward cAMP and folate. Mutants fail to activate two important regulatory signaling pathways, mediated by phosphatidylinositol 3,4,5-trisphosphate (PIP3) and target of rapamycin complex 2 (TORC2), which in combination are required for chemotaxis and cAMP signaling. These results indicate that GskA is required during early stages of Dictyostelium development, in which it is necessary for both chemotaxis and cell signaling.

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