scholarly journals Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor–tropomyosin-receptor kinase signaling in adult rats

Neuroscience ◽  
2011 ◽  
Vol 199 ◽  
pp. 86-102 ◽  
Author(s):  
S.M. Garraway ◽  
J.D. Turtle ◽  
J.R. Huie ◽  
K.H. Lee ◽  
M.A. Hook ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Noxious Stimulation ◽  
Receptor Kinase ◽  
Adult Rats ◽  
Locomotor Recovery ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Receptor Kinase Signaling

scholarly journals Beneficial effects of IL-37 after spinal cord injury in mice

2016 ◽  
Vol 113 (5) ◽  
pp. 1411-1416 ◽  
Author(s):  
Marina Coll-Miró ◽  
Isaac Francos-Quijorna ◽  
Eva Santos-Nogueira ◽  
Abel Torres-Espin ◽  
Philip Bufler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Potential ◽  
Locomotor Recovery ◽  
Beneficial Effects ◽  
Cord Injury ◽  
Contusion Injury ◽  
The Central Nervous System ◽  
Locomotor Deficits ◽  
Spinal Cord Contusion

IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well as acquired immunity. Whether the antiinflammatory properties of IL-37 extend to the central nervous system remains unknown, however. In the present study, we subjected mice transgenic for human IL-37 (hIL-37tg) and wild-type (WT) mice to spinal cord contusion injury and then treated them with recombinant human IL-37 (rIL-37). In the hIL-37tg mice, the expression of IL-37 was barely detectable in the uninjured cords, but was strongly induced at 24 h and 72 h after the spinal cord injury (SCI). Compared with WT mice, hIL-37tg mice exhibited increased myelin and neuronal sparing and protection against locomotor deficits, including 2.5-fold greater speed in a forced treadmill challenge. Reduced levels of cytokines (e.g., an 80% reduction in IL-6) were observed in the injured cords of hIL-37tg mice, along with lower numbers of blood-borne neutrophils, macrophages, and activated microglia. We treated WT mice with a single intraspinal injection of either full-length or processed rIL-37 after the injury and found that the IL-37–treated mice had significantly enhanced locomotor skills in an open field using the Basso Mouse Scale, as well as supported faster speed on a mechanical treadmill. Treatment with both forms of rIL-37 led to similar beneficial effects on locomotor recovery after SCI. This study presents novel data indicating that IL-37 suppresses inflammation in a clinically relevant model of SCI, and suggests that rIL-37 may have therapeutic potential for the treatment of acute SCI.

A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury

2004 ◽  
Vol 189 (2) ◽  
pp. 317-332 ◽  
Author(s):  
C IANNOTTI ◽  
Y PINGZHANG ◽  
C SHIELDS ◽  
Y HAN ◽  
D BURKE ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Contusion Injury ◽  
Spinal Cord Contusion

Locomotor Recovery after Spinal Cord Contusion Injury in Rats Is Improved by Spontaneous Exercise

2003 ◽  
Vol 20 (10) ◽  
pp. 1029-1037 ◽  
Author(s):  
Nico L.U. van Meeteren ◽  
Ruben Eggers ◽  
Alex J. Lankhorst ◽  
Willem Hendrik Gispen ◽  
Frank P.T. Hamers
Keyword(s):  
Spinal Cord ◽  
Locomotor Recovery ◽  
Contusion Injury ◽  
Spinal Cord Contusion
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