Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance

Nitric Oxide ◽  
2004 ◽  
Vol 10 (3) ◽  
pp. 130-140 ◽  
Author(s):  
Rachel Weitzdoerfer ◽  
Harald Hoeger ◽  
Efrem Engidawork ◽  
Mario Engelmann ◽  
Nicolas Singewald ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cognitive Performance ◽  
Neuronal Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase

Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice

Neuroscience ◽  
1999 ◽  
Vol 89 (2) ◽  
pp. 311-315 ◽  
Author(s):  
L.J. Kriegsfeld ◽  
M.J.L. Eliasson ◽  
G.E. Demas ◽  
S. Blackshaw ◽  
T.M. Dawson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Motor Coordination ◽  
Neuronal Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase

scholarly journals Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

1997 ◽  
Vol 17 (18) ◽  
pp. 6908-6917 ◽  
Author(s):  
Cenk Ayata ◽  
Gamze Ayata ◽  
Hideaki Hara ◽  
Russel T. Matthews ◽  
M. Flint Beal ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Type I ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase

Inducible nitric oxide synthase activity is protective in the enterocolitis of IL-10 knock-out mice

1998 ◽  
Vol 114 ◽  
pp. A1107 ◽  
Author(s):  
G.W. Varilek ◽  
F. Yang ◽  
K.S. Ramanujam ◽  
W.J.S. de Villiers ◽  
K.T. Wilson
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

Impaired cognitive performance in neuronal nitric oxide synthase knockout mice is associated with hippocampal protein derangements

Nitric Oxide ◽  
2004 ◽  
Vol 11 (4) ◽  
pp. 316-330 ◽  
Author(s):  
Liselotte Kirchner ◽  
Rachel Weitzdoerfer ◽  
Harald Hoeger ◽  
Angelika Url ◽  
Peter Schmidt ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cognitive Performance ◽  
Knockout Mice ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Knock out of neuronal nitric oxide synthase exacerbates intestinal ischemia/reperfusion injury in mice

2012 ◽  
Vol 349 (2) ◽  
pp. 565-576 ◽  
Author(s):  
Leni R. Rivera ◽  
Louise Pontell ◽  
Hyun-Jung Cho ◽  
Patricia Castelucci ◽  
Michelle Thacker ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Neuronal Nitric Oxide Synthase ◽  
Knock Out ◽  
Intestinal Ischemia Reperfusion ◽  
Oxide Synthase

INDUCIBLE NITRIC OXIDE SYNTHASE KNOCK OUT MICE EXHIBIT RESISTANCE TO THE ACUTE PANCREATITIS INDUCED BY CERULEIN.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 75
Author(s):  
T. Centorrino ◽  
E. Mazzon ◽  
L. Dugo ◽  
A. Ciccolo ◽  
F. A.J. Van de Loo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Cholinesterase Inhibitor Donepezil Dilates Cerebral Parenchymal Arterioles via  the Activation of Neuronal Nitric Oxide Synthase

2008 ◽  
Vol 109 (1) ◽  
pp. 124-129 ◽  
Author(s):  
Katsutoshi Nakahata ◽  
Hiroyuki Kinoshita ◽  
Keiko Hama-Tomioka ◽  
Yuko Ishida ◽  
Naoyuki Matsuda ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Nitric Oxide Synthase ◽  
Acetylcholinesterase Inhibitor ◽  
Brain Slices ◽  
Neuronal Nitric Oxide Synthase ◽  
Immunohistochemical Analysis ◽  
Knock Out ◽  
Arteriolar Wall ◽  
Oxide Synthase

Background An acetylcholinesterase inhibitor donepezil currently is used to treat patients with Alzheimer disease. However, its direct effect on cerebral blood vessels has not been evaluated. The present study was designed to examine whether donepezil induces acute cerebral arteriolar dilation and whether neuronal nitric oxide synthase contributes to this vasodilator response. Methods Brain slices were obtained from neuronal nitric oxide synthase knock-out or C57BL/6J strain (control) mice as well as Wistar rats. Parenchymal arterioles were monitored using videomicroscopy. During constriction to prostaglandin F2alpha (5 x 10 m), donepezil (10-10 m) or acetylcholine (10-10 m) was added. In some experiments, brain slices were treated with a nonselective or a selective nitric oxide synthase inhibitor (N-nitro-L-arginine methyl ester [10 m] and S-methyl-L-thiocitrulline [10 m], respectively). An immunohistochemical analysis was performed using antibodies for neuronal nitric oxide synthase and acetylcholinesterase. Results Acetylcholine concentration-dependently dilated rat parenchymal arterioles, while S-methyl-L-thiocitrulline as well as N-nitro-L-arginine methyl ester completely abolished this response. Donepezil produced arteriolar dilation, which was inhibited by S-methyl-L-thiocitrulline or N-nitro-L-arginine methyl ester. Donepezil failed to induce arteriolar dilation in the brain slice from the neuronal nitric oxide synthase knock-out mice. Immunohistochemical analysis revealed spatial relationship between neuronal nitric oxide synthase and acetylcholinesterase in the arteriolar wall. Conclusions Donepezil produces acute vasodilation induced by a selective activation of neuronal nitric oxide synthase in the cerebral parenchymal arterioles. This agent may be capable of enhancing this enzymatic activity directly or via acetylcholinesterase existing on the arteriolar wall.

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