scholarly journals Mechanisms of Reduced Striatal NMDA Excitotoxicity in Type I Nitric Oxide Synthase Knock-Out Mice

1997 ◽  
Vol 17 (18) ◽  
pp. 6908-6917 ◽  
Author(s):  
Cenk Ayata ◽  
Gamze Ayata ◽  
Hideaki Hara ◽  
Russel T. Matthews ◽  
M. Flint Beal ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Type I ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase

Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance

Nitric Oxide ◽  
2004 ◽  
Vol 10 (3) ◽  
pp. 130-140 ◽  
Author(s):  
Rachel Weitzdoerfer ◽  
Harald Hoeger ◽  
Efrem Engidawork ◽  
Mario Engelmann ◽  
Nicolas Singewald ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cognitive Performance ◽  
Neuronal Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase

Inducible nitric oxide synthase activity is protective in the enterocolitis of IL-10 knock-out mice

1998 ◽  
Vol 114 ◽  
pp. A1107 ◽  
Author(s):  
G.W. Varilek ◽  
F. Yang ◽  
K.S. Ramanujam ◽  
W.J.S. de Villiers ◽  
K.T. Wilson
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity ◽  
Inducible Nitric Oxide

Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice

Neuroscience ◽  
1999 ◽  
Vol 89 (2) ◽  
pp. 311-315 ◽  
Author(s):  
L.J. Kriegsfeld ◽  
M.J.L. Eliasson ◽  
G.E. Demas ◽  
S. Blackshaw ◽  
T.M. Dawson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Motor Coordination ◽  
Neuronal Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase

INDUCIBLE NITRIC OXIDE SYNTHASE KNOCK OUT MICE EXHIBIT RESISTANCE TO THE ACUTE PANCREATITIS INDUCED BY CERULEIN.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 75
Author(s):  
T. Centorrino ◽  
E. Mazzon ◽  
L. Dugo ◽  
A. Ciccolo ◽  
F. A.J. Van de Loo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acute Pancreatitis ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Knock Out ◽  
Knock Out Mice ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Calcium/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium/calmodulin-independent diaphorase and reductase activities

Biochemistry ◽  
1992 ◽  
Vol 31 (12) ◽  
pp. 3243-3249 ◽  
Author(s):  
Harald H. H. W. Schmidt ◽  
R. M. Smith ◽  
M. Nakane ◽  
Ferid Murad
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Type I ◽  
Calcium Calmodulin Dependent ◽  
Oxide Synthase

Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung

1994 ◽  
Vol 266 (6) ◽  
pp. L635-L641 ◽  
Author(s):  
A. J. North ◽  
R. A. Star ◽  
T. S. Brannon ◽  
K. Ujiie ◽  
L. B. Wells ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Fetal Lung ◽  
Mrna Abundance ◽  
Type I ◽  
Fetal Life ◽  
Rat Lung ◽  
Developmentally Regulated ◽  
Oxide Synthase

The successful transition from fetal to neonatal life involves a marked decline in pulmonary vascular resistance which is modulated in part by endothelium-derived nitric oxide. To define the molecular processes which prepare the pulmonary circulation for nitric oxide mediation of vasodilatation at the time of birth, we determined the ontogeny of endothelial nitric oxide synthase (NOS-III) gene expression in lungs from fetal and newborn rats. Maturational changes in lung neuronal NOS (NOS-I) expression were also investigated; the latter isoform has been localized to rat bronchiolar epithelium. NOS proteins were examined by immunoblot analysis, and mRNA abundance was assessed in reverse transcription-polymerase chain reaction assays. Both NOS-III and NOS-I protein were detectable in 16-day fetal lung, they increased 3.8- and 3.1-fold, respectively, to maximal levels at 20 days of gestation (term = 22 day), and they fell postnatally (1-5 days). In parallel with the findings for NOS-III protein, NOS-III mRNA increased from 16 to 20 days gestation and fell after birth. In contrast, NOS-I mRNA abundance declined during late fetal life and rose postnatally. These findings were confirmed by Northern analyses. Thus NOS-III and NOS-I gene expression are developmentally regulated in rat lung, with maximal NOS-III and NOS-I protein present near term. The regulation of pulmonary NOS-III may primarily involve alterations in transcription or mRNA stability, whereas NOS-I expression in the maturing lung may also be mediated by additional posttranscriptional processes.

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