Immediate early gene activation in hippocampus and dorsal striatum: Effects of explicit place and response training

2007 ◽  
Vol 87 (4) ◽  
pp. 583-596 ◽  
Author(s):  
Kathryn M. Gill ◽  
Ilene L. Bernstein ◽  
Sheri J.Y. Mizumori
Keyword(s):  
Gene Activation ◽  
Dorsal Striatum ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Response Training

scholarly journals Sex and estrous cycle differences in immediate early gene activation in the hippocampus and the dorsal striatum after the cue competition task

2017 ◽  
Vol 87 ◽  
pp. 69-79 ◽  
Author(s):  
Shunya Yagi ◽  
Dimka Drewczynski ◽  
Steven R. Wainwright ◽  
Cindy K. Barha ◽  
Olivia Hershorn ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Gene Activation ◽  
Dorsal Striatum ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Cue Competition

scholarly journals Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells

2004 ◽  
Vol 557 (3) ◽  
pp. 773-783 ◽  
Author(s):  
Guoxiang Yuan ◽  
Gautam Adhikary ◽  
Andrew A. McCormick ◽  
John. J. Holcroft ◽  
Ganesh K. Kumar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Intermittent Hypoxia ◽  
Gene Activation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early

Increased immediate early gene activation in the basolateral amygdala following persistent peripheral inflammation.

Neuroreport ◽  
2020 ◽  
Vol 31 (10) ◽  
pp. 724-729
Author(s):  
Julio Cesar Morales-Medina ◽  
Ashutosh Rastogi ◽  
Eric Mintz ◽  
Heather K. Caldwell
Keyword(s):  
Basolateral Amygdala ◽  
Gene Activation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Peripheral Inflammation

scholarly journals Subregion-specific rules govern the distribution of neuronal immediate-early gene induction

2019 ◽  
Vol 117 (38) ◽  
pp. 23304-23310 ◽  
Author(s):  
Ben Jerry Gonzales ◽  
Diptendu Mukherjee ◽  
Reut Ashwal-Fluss ◽  
Yonatan Loewenstein ◽  
Ami Citri
Keyword(s):  
Single Molecule ◽  
Cortical Neurons ◽  
Dorsal Striatum ◽  
Brain Structures ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Projection Neurons ◽  
Recent Experience ◽  
Neuronal Assemblies

The induction of immediate-early gene (IEG) expression in brain nuclei in response to an experience is necessary for the formation of long-term memories. Additionally, the rapid dynamics of IEG induction and decay motivates the common use of IEG expression as markers for identification of neuronal assemblies (“ensembles”) encoding recent experience. However, major gaps remain in understanding the rules governing the distribution of IEGs within neuronal assemblies. Thus, the extent of correlation between coexpressed IEGs, the cell specificity of IEG expression, and the spatial distribution of IEG expression have not been comprehensively studied. To address these gaps, we utilized quantitative multiplexed single-molecule fluorescence in situ hybridization (smFISH) and measured the expression of IEGs (Arc,Egr2, andNr4a1) within spiny projection neurons (SPNs) in the dorsal striatum of mice following acute exposure to cocaine. Exploring the relevance of our observations to other brain structures and stimuli, we also analyzed data from a study of single-cell RNA sequencing of mouse cortical neurons. We found that while IEG expression is graded, the expression of multiple IEGs is tightly correlated at the level of individual neurons. Interestingly, we observed that region-specific rules govern the induction of IEGs in SPN subtypes within striatal subdomains. We further observed that IEG-expressing assemblies form spatially defined clusters within which the extent of IEG expression correlates with cluster size. Together, our results suggest the existence of IEG-expressing neuronal “superensembles,” which are associated in spatial clusters and characterized by coherent and robust expression of multiple IEGs.

scholarly journals Immediate early gene activation throughout the brain is associated with dynamic changes in social context

2018 ◽  
Vol 14 (3) ◽  
pp. 253-265 ◽  
Author(s):  
Cait M. Williamson ◽  
Inbal S. Klein ◽  
Won Lee ◽  
James P. Curley
Keyword(s):  
Social Context ◽  
Gene Activation ◽  
Immediate Early Gene ◽  
Early Gene ◽  
Immediate Early ◽  
Dynamic Changes ◽  
The Brain
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