P3.24 Therapeutic potential of murine mesenchymal stem cells (MSC) from adipose tissue in the treatment of muscular dystrophy in the new double mutant mouse model for the genes Dystrophin and Large

2010 ◽  
Vol 20 (9-10) ◽  
pp. 648
Author(s):  
P.C.M. Martins-Machado ◽  
P.C.G. Onofre-Oliveira ◽  
D. Ayub-Guerrieri ◽  
D. Gotlieb ◽  
A. Fernandes ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Muscular Dystrophy ◽  
Mouse Model ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Therapeutic Potential ◽  
Double Mutant Mouse

scholarly journals Therapeutic potential of bone marrow-derived mesenchymal stem cells in formed aortic aneurysms of a mouse model

2014 ◽  
Vol 45 (5) ◽  
pp. e156-e165 ◽  
Author(s):  
A. Yamawaki-Ogata ◽  
X. Fu ◽  
R. Hashizume ◽  
K. L. Fujimoto ◽  
Y. Araki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Therapeutic Potential ◽  
Aortic Aneurysms

scholarly journals Effects of Human Adipose Tissue-Derived and Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in a Dextran Sulfate Sodium-Induced Mouse Model

2019 ◽  
Vol 8 (1) ◽  
pp. 185-199 ◽  
Author(s):  
Shunzo Ikarashi ◽  
Atsunori Tsuchiya ◽  
Yuzo Kawata ◽  
Yuichi Kojima ◽  
Takayuki Watanabe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Mouse Model ◽  
Umbilical Cord ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Human Adipose Tissue ◽  
Umbilical Cord Tissue

scholarly journals Rad51c- and Trp53-double-mutant mouse model reveals common features of homologous recombination-deficient breast cancers

Oncogene ◽  
2016 ◽  
Vol 35 (35) ◽  
pp. 4601-4610 ◽  
Author(s):  
M Tumiati ◽  
P M Munne ◽  
H Edgren ◽  
S Eldfors ◽  
A Hemmes ◽  
...  
Keyword(s):  
Homologous Recombination ◽  
Mouse Model ◽  
Double Mutant ◽  
Mutant Mouse ◽  
Breast Cancers ◽  
Common Features ◽  
Double Mutant Mouse

scholarly journals Human Adipose Tissue-Derived Mesenchymal Stem Cells Improve Postnatal Neovascularization in a Mouse Model of Hindlimb Ischemia

2006 ◽  
Vol 17 (5-6) ◽  
pp. 279-290 ◽  
Author(s):  
Mi Hyang Moon ◽  
Sun Young Kim ◽  
Yeon Jeong Kim ◽  
Su Jin Kim ◽  
Jae Bong Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Mouse Model ◽  
Human Adipose Tissue ◽  
Hindlimb Ischemia

scholarly journals Adipose tissue-derived mesenchymal stem cells have better restorative capacity than bone marrow-derived cells in a cerebellar ataxic rat model

2020 ◽  
Author(s):  
Rasha Att ◽  
Angie Ameen ◽  
Horeya Korayem ◽  
Noha Abogresha ◽  
Yasser El-Wazir
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Growth Factor ◽  
Motor Performance ◽  
Therapeutic Potential ◽  
Monosodium Glutamate ◽  
Control Group

IntroductionRegenerative treatment using stem cells represents a potentially effective therapy for cerebellar ataxia (CA). We compared the therapeutic potential of adipose tissue stem cells (ASCs) and bone marrow mesenchymal stem cells (BM-MSCs) in a rodent monosodium glutamate (MSG)-induced CA cell (BM-MSC) model.Material and methodsFemale Wistar rats (n = 40) were equally divided into a saline-treated control group and 3 MSG-induced CA groups randomly treated with either saline, or 1 × 106 ASCs or BM-MSCs. We assessed the following: 1) cerebellar motor functions in vivo (by Rotarod test, open-field test, and Quantitative gait analysis); 2) cerebellar histological architecture; and 3) cerebellar immunohistochemical examination of the Bax/Bcl-2 ratio as in indicator of apoptosis, and the levels of vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) as neuroprotective factors.ResultsTreatment with either of the MSCs improved MSG-induced poor motor performance, restored the disrupted Purkinje cell layer, decreased neuronal apoptosis and enhanced cerebellar VEGF and IGF-1 levels observed in CA rats. Adipose tissue stem cells showed superiority over BM-MSCs in the improvement of some motor performance parameters and cerebellar VEGF and IGF-1 levels.ConclusionsIn conclusion, both stem cell types induced structural, physiological, and biochemical improvement, with ASCs being best for treatment of CA.

Human adipose tissue-derived mesenchymal stem cells: Characteristics and therapeutic potential as cellular vehicles for prodrug gene therapy against brainstem gliomas

2012 ◽  
Vol 48 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Seung Ah Choi ◽  
Ji Yeoun Lee ◽  
Kyu-Chang Wang ◽  
Ji Hoon Phi ◽  
Sang Hoon Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Therapeutic Potential ◽  
Human Adipose Tissue
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