Evaluation of the anticonvulsant and neuroprotective effect of intracerebral administration of growth hormone in rats

Abstract. Radioimmunoassayable IGF-I levels were measured in the cerebrospinal fluid and plasma of pig fetuses at 94 days gestational age. Mean plasma IGF-I levels were 128.5 ± 5.8 μg/l while the concentration in the cerebrospinal fluid was 25.8 ± 4.4 μg/l. The effect of intracerebroventricular administration of IGF-I on circulating GH levels was also studied in pig fetuses in utero. Eighteen pig fetuses were fitted with indwelling carotid artery and juglar vein catheters. Nine fetuses were given 1500 ng of pure IGF-I in 100 μl 0.9% saline by direct injection into a right lateral ventricle. Nine further fetuses (controls) were similarly given 100 μl of saline without IGF-I. GH levels in the control fetuses were ~200 μg/l and showed marked fluctuations with episodic intervals of about 40 min. By contrast, in the IGF-I-treated fetuses, GH levels were dramatically lowered by 20 min after IGF administration and remained low throughout the 4-h study. The episodic variations in GH were abolished and levels remained fairly constant at ca. 40 μg/l. From these results we surmise that the low levels of IGF-I in the fetus may contribute to their high GH levels. At this stage it is not possible to identify whether the IGF-I inhibition is a direct effect on the pituitary or is mediated by increased somatostatin, decreased GHRH or both.

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Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke

Neurological Research ◽

10.1080/01616412.2016.1235249 ◽

2016 ◽

Vol 38 (11) ◽

pp. 950-958 ◽

Cited By ~ 3

Author(s):

N. Subirós ◽

H. Pérez-Saad ◽

L. Aldana ◽

C. L. Gibson ◽

W. S. Borgnakke ◽

...

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Neuroprotective Effect ◽

Experimental Stroke ◽

Epidermal Growth

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NEUROPROTECTIVE EFFECT OF GROWTH HORMONE (GH) IN HYPOXIC ORGANOTYPIC CULTURES OF CHICKEN CEREBELLUM

Frontiers in Endocrinology ◽

10.3389/conf.fendo.2011.04.00120 ◽

2011 ◽

Vol 2 ◽

Author(s):

Luna Maricela

Keyword(s):

Growth Hormone ◽

Neuroprotective Effect ◽

Organotypic Cultures

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Decision letter for "Neurochemical phenotype of growth hormone‐responsive cells in the mouse paraventricular nucleus of the hypothalamus"

10.1002/cne.25017/v2/decision1 ◽

2020 ◽

Keyword(s):

Growth Hormone ◽

Paraventricular Nucleus

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Association of pituitary adenoma with neuronal christoma: A TEM study

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010016889x ◽

1994 ◽

Vol 52 ◽

pp. 232-233

Author(s):

Eva Horvath ◽

Kalman Kovacs ◽

B. W. Scheithauer ◽

R. V. Lloyd ◽

H. S. Smyth

Keyword(s):

Growth Hormone ◽

Pituitary Adenoma ◽

Pituitary Tumor ◽

Nervous Tissue ◽

Alternative Explanation ◽

Growth Hormone Releasing Hormone ◽

Cell Hyperplasia ◽

Releasing Hormone ◽

Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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