Evaluation of geranylgeranylacetone against cisplatin-induced ototoxicity by auditory brainstem response, heat shock proteins and oxidative levels in guinea pigs

2017 ◽  
Vol 61 ◽  
pp. 29-35 ◽  
Author(s):  
Wu-Chia Lo ◽  
Chen-Tu Wu ◽  
Hillary Chiao Lee ◽  
Yi-Ho Young ◽  
Yih-Leong Chang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Auditory Brainstem Response ◽  
Guinea Pigs ◽  
Auditory Brainstem ◽  
Brainstem Response ◽  
Shock Proteins

Effects of noise exposure on neonatal auditory brainstem response thresholds in pregnant guinea pigs at different gestational periods

2016 ◽  
Vol 43 (1) ◽  
pp. 78-86
Author(s):  
Chihiro Morimoto ◽  
Kazuhiko Nario ◽  
Tadashi Nishimura ◽  
Ryota Shimokura ◽  
Hiroshi Hosoi ◽  
...  
Keyword(s):  
Auditory Brainstem Response ◽  
Guinea Pigs ◽  
Noise Exposure ◽  
Auditory Brainstem ◽  
Brainstem Response ◽  
Response Thresholds

The Auditory Brainstem Response of Aged Guinea Pigs

1998 ◽  
Vol 118 (5) ◽  
pp. 673-680 ◽  
Author(s):  
Neil J. Ingham, Sally K. Thornton,
Keyword(s):  
Auditory Brainstem Response ◽  
Guinea Pigs ◽  
Auditory Brainstem ◽  
Brainstem Response

Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs

2016 ◽  
Vol 156 (3) ◽  
pp. 543-548 ◽  
Author(s):  
Alan D. Tate ◽  
Patrick J. Antonelli ◽  
Kyle R. Hannabass ◽  
Carolyn O. Dirain
Keyword(s):  
Hearing Loss ◽  
Auditory Brainstem Response ◽  
Guinea Pigs ◽  
Outer Hair Cell ◽  
Auditory Brainstem ◽  
Response Threshold ◽  
Saline Control ◽  
Control Group ◽  
Cochlear Hair Cells ◽  
Brainstem Response

Objective To determine if mitoquinone (MitoQ) attenuates cisplatin-induced hearing loss in guinea pigs. Study Design Prospective and controlled animal study. Setting Academic, tertiary medical center. Subjects and Methods Guinea pigs were injected subcutaneously with either 5 mg/kg MitoQ (n = 9) or normal saline (control, n = 9) for 7 days and 1 hour before receiving a single dose of 10 mg/kg cisplatin. Auditory brainstem response thresholds were measured before MitoQ or saline administration and 3 to 4 days after cisplatin administration. Results Auditory brainstem response threshold shifts after cisplatin treatment were smaller by 28 to 47 dB in guinea pigs injected with MitoQ compared with those in the control group at all tested frequencies (4, 8, 16, and 24 kHz, P = .0002 to .04). Scanning electron microscopy of cochlear hair cells showed less outer hair cell loss and damage in the MitoQ group. Conclusion MitoQ reduced cisplatin-induced hearing loss in guinea pigs. MitoQ appears worthy of further investigation as a means of preventing cisplatin ototoxicity in humans.

scholarly journals Electrically Evoked Auditory Brainstem Response by Using Bionic Auditory Membrane in Guinea Pigs

2013 ◽  
Vol 8 (3) ◽  
pp. 198-208 ◽  
Author(s):  
Hirofumi SHINTAKU ◽  
Takatoshi INAOKA ◽  
Takayuki NAKAGAWA ◽  
Satoyuki KAWANO ◽  
Juichi ITO
Keyword(s):  
Auditory Brainstem Response ◽  
Guinea Pigs ◽  
Auditory Brainstem ◽  
Brainstem Response

scholarly journals Effect of hypoxia on heat-shock proteins (HSPs) in the cerebral cortex of the guinea-pigs newborns

1999 ◽  
Vol 45 (6) ◽  
pp. 907-907
Author(s):  
Giuseppe Buonocore ◽  
Sabrina Liberatori ◽  
Luca Bini ◽  
Vitaliano Pallini ◽  
Om P Mishra ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Guinea Pigs ◽  
Shock Proteins
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