Effect of Brazilian Red Propolis on the Development and Immunohistochemical Expression of Ki-67 and p16INK4A in DMBA-Induced Oral Squamous Cell Carcinomas

Author(s):  
Genecy Calado De Melo ◽  
José Cleveilton Dos Santos ◽  
Esaú Pinheiro Dos Santos ◽  
Danielle Rodrigues Ribeiro Cavalcante ◽  
Juliana Cordeiro Cardoso ◽  
...  
2008 ◽  
Vol 23 (3) ◽  
pp. 176-181 ◽  
Author(s):  
M. De Vincentiis ◽  
P. Di Cello ◽  
F. Censi ◽  
M. Leopizzi ◽  
S. Natalizi ◽  
...  

Fatty acid synthase (FAS) is a recently discovered molecule involved in the energy supply to normal cells. FAS is overexpressed in neoplastic tissues because of their increased energy needs. We explored the immunohistochemical expression of FAS, Ki-67 and p53 in squamous cell carcinomas (SCC) of the larynx and their association with clinicopathological features and outcome. Specimens from 43 patients with SCC were evaluated. Statistical analysis revealed an association between poorly differentiated laryngeal carcinomas and FAS expression (p<0.005) and between FAS and Ki-67 overexpression (p<0.001). Finally, FAS expression was associated with overall survival (p<0.001). We suggest that FAS is a powerful prognostic indicator whose strength can be enhanced when it is evaluated together with clinicopathological data and Ki-67 expression.


2006 ◽  
Vol 12 (2) ◽  
pp. 87-91 ◽  
Author(s):  
Yukihiro Hiraishi ◽  
Takeshi Wada ◽  
Ken Nakatani ◽  
Kenji Negoro ◽  
Shigeyuki Fujita

2009 ◽  
Vol 3 (4) ◽  
pp. 263-270 ◽  
Author(s):  
Dimitrios Papavasileiou ◽  
Konstantinos Tosios ◽  
Panos Christopoulos ◽  
Nikolaos Goutas ◽  
Dimitrios Vlachodimitropoulos

2015 ◽  
Vol 2 (1) ◽  
pp. 8-14
Author(s):  
Dena N. Mohammad ◽  
◽  
Balkees T. Garib ◽  
Hassanain H. Khudeir ◽  
◽  
...  

Sign in / Sign up

Export Citation Format

Share Document