Immunoexpression of hMSH2, p53, and p21 in Actinic Cheilitis and Lower Lip Squamous Cell Carcinoma

This study aimed to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Twenty LLSCCs with regional nodal metastasis and 20 LLSCCs without metastasis were selected. The distribution of staining and the percentage of GLUT-1 and GLUT-3 staining in each tumor core and at the deep invasive front were assessed. Most tumors (70%) exhibited peripheral staining for GLUT-1 in nests, sheets and islands of neoplastic cells, whereas predominantly central staining was observed for GLUT-3 (72.5%). A high percentage of GLUT-1-positive cells was observed at the deep invasive front and in the tumor core of metastatic and non-metastatic tumors (p>0.05). The percentage of GLUT-1-positive cells was much higher than that of GLUT-3-positive cells both in the deep invasive front (p<0.001) and in the tumor core (p<0.001) of LLSCCs. No significant differences in the percentage of GLUT-1- and GLUT-3-positive cells were observed according to nodal metastasis, clinical stage or histological grade of malignancy (p>0.05). In conclusion, the results of the present study suggest an important role of GLUT-1 in glucose uptake in LLSCCs, although this protein does not seem to be involved in the progression of these tumors. On the other hand, GLUT-3 expression may represent a secondary glucose uptake mechanism in LLSCCs.

Download Full-text

Squamous cell carcinoma on the lower lip after using topical calcineurin inhibitor

JDDG Journal der Deutschen Dermatologischen Gesellschaft ◽

10.1111/ddg.12133 ◽

2013 ◽

Vol 11 (9) ◽

pp. 868-870 ◽

Cited By ~ 1

Author(s):

Şule Güngör ◽

Gonca Gökdemir ◽

Nesimi Büyükbabani ◽

Nilgun Bahçetepe

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Calcineurin Inhibitor ◽

Lower Lip ◽

Topical Calcineurin Inhibitor

Download Full-text

Squamous cell carcinoma of lower lip reconstructed with bilateral fan flap

Annals of Maxillofacial Surgery ◽

10.4103/ams.ams_3_16 ◽

2019 ◽

Vol 9 (1) ◽

pp. 211

Author(s):

Semmia Mathivanan ◽

BhattD Supreet ◽

MustafaI Merchant ◽

NiranjanS Patil

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Lower Lip

Download Full-text

Surgery for recurrent lower lip carcinoma

Kathmandu University Medical Journal ◽

10.3126/kumj.v6i3.1715 ◽

1970 ◽

Vol 6 (3) ◽

pp. 375-378

Author(s):

S Maharjan ◽

M Bista ◽

KC Toran ◽

KD Joshi

Keyword(s):

Squamous Cell Carcinoma ◽

Medical Journal ◽

Case Report ◽

Cell Carcinoma ◽

Key Words ◽

Squamous Cell ◽

Lower Lip ◽

Recurrent Squamous Cell Carcinoma ◽

Lip Carcinoma ◽

Deltopectoral Flap

A 38 year old gentleman presented with recurrent Squamos cell carcinoma of lower lip. He had earlier undergone previous surgeries and radiotherapy. At the time that he presented in KMCTH his lower lip area was much scarred and the tongue was shrunk and unavailable for vermilion reconstruction. This case report is an account of the various treatment carried out to reconstruct the lip. It was done with co-operation of the ENT department. Key words: Recurrent squamous cell carcinoma, Gillies fan flap, Deltopectoral flap, Delay of flaps doi: 10.3126/kumj.v6i3.1715 Kathmandu University Medical Journal (2008), Vol. 6, No. 3, Issue 23, 375-378

Download Full-text