Immunohistochemical Expression of GLUT-1 and Ki-67 in Oral Vascular Anomalies

CONTEXT: Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer OBJECTIVE: To analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. METHOD: Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", São Paulo, SP, Brazil, between 2002 and 2005. Thin sections (4 µm) were subjected to immunohistochemical reactions, and immunoexpression staining scores were obtained. The scores were correlated with the degree of cell differentiation, staging, disease-free interval, recurrence, survival and specific mortality. The study variables were analyzed using the chi-square and Kaplan-Meier tests to investigate associations with the markers. The significance of the differences between the curves of the disease-free interval and survival was analyzed using the Logrank and Wilcoxon tests. RESULTS: The immunohistochemical expression of p53 was positive in 70 tumors (85.4%) and negative in 12 (14.6%). The expression of bcl-2 was positive in 26 (31.7%) and negative in 56 (68.3%). The expression of Ki-67 was positive in 62 (75.6%) and negative in 20 (24.4%). There was no statistically significant correlation between the expressions of these markers separately or in conjunction, in relation to the degree of cell differentiation, staging, disease-free interval, survival and specific mortality. In relation to recurrence, there was a statistically significant correlation with positive expression of Ki-67 (P = 0.035). CONCLUSION: The immunohistochemical expression of Ki-67 in colorectal cancer is associated with recurrence of this disease.

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Immunohistochemical Expression of Ki-67 to Predict Lymph Node Involvement in Clinical Stage I Nonseminomatous Germ Cell Tumors

The Journal of Urology ◽

10.1016/s0022-5347(01)64571-3 ◽

1997 ◽

Vol 158 (2) ◽

pp. 620-625 ◽

Cited By ~ 10

Author(s):

Axel Heidenreich ◽

Noah S. Schenkmann ◽

Isabell A. Sesterhenn ◽

F. Kash Mostofi ◽

William F. McCarthy ◽

...

Keyword(s):

Lymph Node ◽

Germ Cell ◽

Clinical Stage ◽

Germ Cell Tumors ◽

Lymph Node Involvement ◽

Stage I ◽

Immunohistochemical Expression ◽

Ki 67 ◽

Node Involvement ◽

Nonseminomatous Germ Cell Tumors

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A Semi-quantitative analysis of immunohistochemical expression of p63, Ki-67, Cyclin-D1, and p16 in common oral potentially malignant disorders and oral squamous cell carcinoma

Journal of Dr NTR University of Health Sciences ◽

10.4103/jdrntruhs.jdrntruhs_13_18 ◽

2018 ◽

Vol 7 (2) ◽

pp. 120 ◽

Cited By ~ 1

Author(s):

P Sharada ◽

Uma Swaminathan ◽

BR Nagamalini ◽

K Vinodkumar ◽

BK Ashwini ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Quantitative Analysis ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Cyclin D1 ◽

Immunohistochemical Expression ◽

Oral Potentially Malignant Disorders ◽

Ki 67 ◽

Potentially Malignant Disorders ◽

Potentially Malignant

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Relationship of a new histological categorization of ductal carcinoma in situ of the breast with size and the immunohistochemical expression of p53, c-erb B2, bcl-2, and ki-67

Human Pathology ◽

10.1016/s0046-8177(97)90014-9 ◽

1997 ◽

Vol 28 (8) ◽

pp. 974-979 ◽

Cited By ~ 55

Author(s):

Lloyd Mack ◽

Nancy Kerkvliet ◽

Gordon Doig ◽

Frances P O'Malley

Keyword(s):

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Ductal Carcinoma ◽

Immunohistochemical Expression ◽

Ki 67 ◽

Relationship Of

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Cutaneous Vascular Anomalies Associated With Neural Tube Defects: Nomenclature and Pathology Revisited

Neurosurgery ◽

10.1227/neu.0b013e3182134360 ◽

2011 ◽

Vol 69 (1) ◽

pp. 112-118 ◽

Cited By ~ 3

Author(s):

Todd Maugans ◽

Rachel M Sheridan ◽

Denise Adams ◽

Anita Gupta

Keyword(s):

International Society ◽

Neural Tube ◽

Neural Tube Defects ◽

Vascular Malformations ◽

Strong Association ◽

Vascular Anomalies ◽

Vascular Lesions ◽

Dermal Sinus ◽

Cutaneous Lesions ◽

Glut 1

Abstract BACKGROUND: Lumbosacral cutaneous vascular anomalies associated with neural tube defects are frequently described in the literature as “hemangiomas.” The classification system for pediatric vascular anomalies developed by the International Society for the Study of Vascular Anomalies provides a framework to accurately diagnose these lesions. OBJECTIVE: To apply this classification to vascular cutaneous anomalies overlying myelodysplasias. METHODS: A retrospective analysis of patients with neural tube defects and lumbosacral cutaneous vascular lesions was performed. All eligible patients had detailed histopathologic analysis of skin and spinal cord/placode lesions. Clinical and radiologic features were analyzed. Conventional histology and GLUT-1 immunostaining were performed to differentiate infantile capillary hemangiomas from capillary vascular malformations. RESULTS: Ten cases with cutaneous lesions associated with neural tube defects were reviewed. Five lesions were diagnosed as infantile capillary hemangiomas based upon histology and positive GLUT-1 endothelial reactivity. These lesions had a strong association with dermal sinus tracts. No reoperations were required for residual intraspinal vascular lesions, and overlying cutaneous vascular anomalies involuted with time. The remaining 5 lesions were diagnosed as capillary malformations. These occurred with both open and closed neural tube defects, did not involute, and demonstrated enlargement and darkening due to vascular congestion. CONCLUSION: The International Society for the Study of Vascular Anomalies scheme should be used to describe the cutaneous vascular lesions associated with neural tube defects: infantile capillary hemangiomas and capillary malformations. We advocate that these lesions be described as “vascular anomalies” or “stains” pending accurate diagnosis by clinical, histological, and immunohistochemical evaluations.

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