IMAGING FEATURES OF AMELOBLASTOMAS AND KERATOCYSTIC ODONTOGENIC TUMORS: THE ROLE OF CT IN CORTICAL BONE ANALYSIS

Keratocystic odontogenic tumors (KCOTs, previously known as odontogenic keratocysts) are aggressive jaw lesions that may occur in isolation or in association with nevoid basal cell carcinoma syndrome (NBCCS). Mutations in the PTCH1 ( PTCH) gene are responsible for NBCCS and are related in tumors associated with this syndrome. Mutations in the SMO gene have been identified in basal cell carcinoma and in medulloblastoma, both of which are features of NBCCS. To clarify the role of PTCH1 and SMO in KCOTs, we undertook mutational analysis of PTCH1 and SMO in 20 sporadic and 10 NBCCS-associated KCOTs, and for SMO, 20 additional cases of KCOTs with known PTCH1 status were also included. Eleven novel (1 of which occurred twice) and 5 known PTCH1 mutations were identified. However, no pathogenic mutation was detected in SMO. Our findings suggest that mutations are rare in SMO, but frequent in PTCH1 in sporadic and NBCCS-associated KCOTs. Abbreviations: NBCCS, nevoid basal cell carcinoma syndrome; KCOTs, keratocystic odontogenic tumors; BCCs, basal cell carcinomas.

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Are All Odontogenic Keratocysts Keratocystic Odontogenic Tumors? Correlation between Imaging Features and Epithelial Cell Proliferation

Journal of Clinical Imaging Science ◽

10.4103/2156-7514.106616 ◽

2013 ◽

Vol 3 (1) ◽

pp. 3 ◽

Cited By ~ 5

Author(s):

Harkanwal Singh ◽

Prince Kumar ◽

Amit Nayar ◽

Asha Raj

Keyword(s):

Cell Proliferation ◽

Epithelial Cell ◽

Odontogenic Tumors ◽

Imaging Features ◽

Epithelial Cell Proliferation ◽

Odontogenic Keratocysts ◽

Keratocystic Odontogenic Tumors

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Abstract 4204:Essential role of odontoblastic Smad4 in suppressing multiple keratocystic odontogenic tumors in mice

10.1158/1538-7445.am10-4204 ◽

2010 ◽

Author(s):

Yuanrong Gao ◽

Guan Yang ◽

Tujun Weng ◽

Juan Du ◽

Xuejiu Wang ◽

...

Keyword(s):

Essential Role ◽

Odontogenic Tumors ◽

Keratocystic Odontogenic Tumors

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Current Role of Carnoy's Solution in Treating Keratocystic Odontogenic Tumors

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2015.07.018 ◽

2016 ◽

Vol 74 (2) ◽

pp. 278-282 ◽

Cited By ~ 14

Author(s):

Jordan Ecker ◽

Rutger ter Horst ◽

David Koslovsky

Keyword(s):

Odontogenic Tumors ◽

Current Role ◽

Carnoy’S Solution ◽

Keratocystic Odontogenic Tumors

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Juvenile xanthogranuloma of the subdural spaces mimicking chronic hematoma with positive FDG uptake on PET: case report

Journal of Neurosurgery Pediatrics ◽

10.3171/2020.4.peds19624 ◽

2020 ◽

Vol 26 (4) ◽

pp. 449-453

Author(s):

Jacob A. Kahn ◽

Jeffrey T. Waltz ◽

Ramin M. Eskandari ◽

Cynthia T. Welsh ◽

Michael U. Antonucci

Keyword(s):

Potential Role ◽

Response To Treatment ◽

Juvenile Xanthogranuloma ◽

Imaging Features ◽

Limited Information ◽

Advanced Imaging ◽

Systemic Involvement ◽

The Central Nervous System ◽

Infancy And Early Childhood

The authors report an unusual presentation of juvenile xanthogranuloma (JXG), a non–Langerhans cell histiocytosis of infancy and early childhood. This entity typically presents as a cutaneous head or neck nodule but can manifest with more systemic involvement including in the central nervous system. However, currently there is limited information regarding specific imaging features differentiating JXG from other neuropathological entities, with diagnosis typically made only after tissue sampling. The authors reviewed the initial images of a young patient with shunt-treated hydrocephalus and enlarging, chronic, extraaxial processes presumed to reflect subdural collections from overshunting, and they examine the operative discovery of a mass lesion that was pathologically proven to be JXG. Their results incorporate the important associated histological and advanced imaging features, including previously unreported metabolic activity on FDG PET. Ultimately, the case underscores the need to consider JXG in differential diagnoses of pediatric intracranial masses and highlights the potential role of PET in the initial diagnosis and response to treatment.

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