A compact and high sensitive photometer based on axial multi-reflection inside metal capillary: Application to detecting nitrite of nanomolar concentration

2021 ◽  
Vol 146 ◽  
pp. 106705
Author(s):  
Xuejing Li ◽  
Hui Huang ◽  
Weicheng Cai ◽  
Min Bai ◽  
Jian Zhao ◽  
...  
Keyword(s):  
Nanomolar Concentration ◽  
Metal Capillary

scholarly journals Nanomolar concentration of triclocarban increases the vulnerability of rat thymocytes to oxidative stress

2013 ◽  
Vol 38 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Yasuhiro Kanbara ◽  
Kazuyoshi Murakane ◽  
Yumiko Nishimura ◽  
Masaya Satoh ◽  
Yasuo Oyama
Keyword(s):  
Oxidative Stress ◽  
Nanomolar Concentration

scholarly journals Sorafenib is a potent inhibitor of FIP1L1-PDGFRα and the imatinib-resistant FIP1L1-PDGFRα T674I mutant

Blood ◽  
2006 ◽  
Vol 108 (4) ◽  
pp. 1374-1376 ◽  
Author(s):  
Els Lierman ◽  
Cedric Folens ◽  
Elizabeth H. Stover ◽  
Nicole Mentens ◽  
Helen Van Miegroet ◽  
...  
Keyword(s):  
Low Dose ◽  
Potent Inhibitor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Low Doses ◽  
Chronic Eosinophilic Leukemia ◽  
Nanomolar Concentration ◽  
Imatinib Resistant ◽  
Factor Receptor Alpha ◽  
Induced Apoptosis

Abstract The FIP1L1-PDGFRA oncogene is a common cause of chronic eosinophilic leukemia (CEL), and encodes an activated tyrosine kinase that is inhibited by imatinib. FIP1L1-PDGFRA–positive patients with CEL respond to low-dose imatinib therapy, but resistance due to acquired T674I mutation has been observed. We report here the identification of sorafenib as a potent inhibitor of the FIP1 like 1–platelet-derived growth factor receptor alpha (FIP1L1-PDGFRα) (T674I) mutant. Sorafenib inhibited the proliferation of FIP1L1-PDGFRα and FIP1L1-PDGFRα(T674I)–transformed Ba/F3 cells and induced apoptosis of the EOL-1 cell line at a low nanomolar concentration. Western blot analysis confirmed that these effects were due to a direct effect on FIP1L1-PDGFRα and FIP1L1-PDGFRα(T674I). Sorafenib was recently approved for the treatment of renal cell carcinoma. Our data suggest that low doses of sorafenib could be efficient for the treatment of FIP1L1-PDGFRA–positive CEL and could be used to overcome resistance to imatinib associated with the T674I mutation.

P1-241 Aβ1-42 can kill murine N2A neuroblastoma cells at nanomolar concentration

2004 ◽  
Vol 25 ◽  
pp. S165
Author(s):  
Zhenfu Wang ◽  
Zelan Wei ◽  
X.-M. Li ◽  
Luning Wang
Keyword(s):  
Neuroblastoma Cells ◽  
Nanomolar Concentration

scholarly journals Determination of 3-keto-valproate in urine by metal capillary gas chromatography.

1989 ◽  
Vol 5 (3) ◽  
pp. 301-304 ◽  
Author(s):  
Satoshi KAWAI ◽  
Ryota NISHIOKA ◽  
Masaharu NAKAHIGASHI ◽  
Kazuko KONDO ◽  
Yuzi TAKAYAMA
Keyword(s):  
Gas Chromatography ◽  
Capillary Gas Chromatography ◽  
Metal Capillary

scholarly journals Lysine-based Cluster Mannosides That Inhibit Ligand Binding to the Human Mannose Receptor at Nanomolar Concentration

1996 ◽  
Vol 271 (45) ◽  
pp. 28024-28030 ◽  
Author(s):  
Erik A. L. Biessen ◽  
Femke Noorman ◽  
Marco E. van Teijlingen ◽  
Johan Kuiper ◽  
Marrie Barrett-Bergshoeff ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Mannose Receptor ◽  
Nanomolar Concentration
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