Recurrence and malignant transformation rates of high grade oral epithelial dysplasia over a 10 year follow up period and the influence of surgical intervention, size of excision biopsy and marginal clearance in a UK regional maxillofacial surgery unit

Oral Oncology ◽  
2021 ◽  
Vol 121 ◽  
pp. 105462
Author(s):  
Ciro Gilvetti ◽  
Chandni Soneji ◽  
Brian Bisase ◽  
Andrew William Barrett
Keyword(s):  
Malignant Transformation ◽  
Surgical Intervention ◽  
Maxillofacial Surgery ◽  
Epithelial Dysplasia ◽  
Excision Biopsy ◽  
High Grade ◽  
Oral Epithelial Dysplasia ◽  
Transformation Rates ◽  
Oral Epithelial

scholarly journals Similar Effect of P16 Hydroxymethylation and True Methylation on Prediction of Malignant Transformation of Oral Epithelial Dysplasia: A Prospective Study

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 211s-211s
Author(s):  
H. Liu ◽  
Z. Liu ◽  
X. Liu ◽  
S. Xu ◽  
L. Wang ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Cancer Progression ◽  
Odds Ratio ◽  
Progression Free Survival ◽  
Epithelial Dysplasia ◽  
Progression Rate ◽  
Double Blind ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

Background: Total P16 methylation (P16M), including P16 hydroxymethylation (P16H) and true-P16M, correlates with malignant transformation of oral epithelial dysplasia (OED). Both true-P16M and P16H are early events in carcinogenesis. Aim: The aim of this study is to prospectively determine if discrimination of true-P16M from P16H similarly is necessary for prediction of cancer development from OEDs. Methods: Patients (n = 265) with mild or moderate OED were recruited into the double-blind 2-center cohort. Total-P16M and P16H were analyzed using the 115-bp MethyLight, TET-assistant bisulfite (TAB) methylation-specific PCR (MSP), and TAB-sequencing. Total-P16M-positive and P16H-negative samples were defined as true-P16M-positive. Progression of OEDs was monitored for a minimum 24 months follow-up period. Results: P16H was detected in 23 of 73 (31.5%) total-P16M-positive OEDs. Follow-up information was obtained from 247 patients with an ultimate compliance of 93.2%. OED-derived squamous cell carcinomas were observed in 13.0% (32/247) patients during the follow-up (median, 41.0 months). The cancer progression rate for total-P16M-positive patients was significantly increased when compared with total-P16M-negative patients (23.3% vs 8.6%; adjusted odds ratio = 2.67 [95% CI: 1.19-5.99]). However, the cancer progression rate was similar between P16H- and true-P16M-positive OEDs (26.1% [6/23] vs 22.0% [11/50]; odds ratio = 0.80 [95% CI: 0.22-2.92]). The progression-free survival was also similar for these patients. Conclusion: P16H and true-P16M are similar biomarkers for determining malignant potential of OEDs. Discrimination of P16H from true-P16M, at least in OED, may be not necessary in clinical applications.

scholarly journals Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
High Rate ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Observational Cohort ◽  
Oral Epithelial

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

scholarly journals Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq

Oncotarget ◽  
2015 ◽  
Vol 6 (37) ◽  
pp. 40186-40201 ◽  
Author(s):  
Caroline Conway ◽  
Jennifer L. Graham ◽  
Preetha Chengot ◽  
Catherine Daly ◽  
Rebecca Chalkley ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

The clinical determinants of malignant transformation in oral epithelial dysplasia

Oral Oncology ◽  
2012 ◽  
Vol 48 (10) ◽  
pp. 969-976 ◽  
Author(s):  
M.W. Ho ◽  
J.M. Risk ◽  
J.A. Woolgar ◽  
E.A. Field ◽  
J.K. Field ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

scholarly journals Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia

2020 ◽  
Author(s):  
Michael W Ho ◽  
Mark Ryan ◽  
Juhi Gupta ◽  
Asterios Triantafyllou ◽  
Janet Risk ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Tissue Sample ◽  
Good Evidence ◽  
Epithelial Dysplasia ◽  
Clinicopathological Parameters ◽  
Post Translational Modification ◽  
Oral Epithelial Dysplasia ◽  
Damage Sensing ◽  
Related Proteins ◽  
Oral Epithelial

Abstract Background: Predicting malignant transformation in oral epithelial dysplasia(OED) is a clinical challenge. The higher rate of malignant transformation in non-smokers supports an endogenous aetiology. Loss of FANCD2 and associated proteins could lead to genomic instability and oncogenesis. Patients & Methods: Longitudinal archival samples from 40 individuals with OED from time of diagnosis to the most recent review in 23 stable OED; or until excision of the SCC in 17 unstable OED undergoing malignant transformation. Histopathological reassessment, immunohistochemistry for FANCD2 and Western blotting for phosphorylation/monubiquitination status of ATR, CHK1, FANCD2 and FANCG were undertaken on each tissue sample. Results: Decreased expression of FANCD2 was observed in the diagnostic biopsy of OED lesions which later underwent malignant transformation. Combining the FANCD2 expression scores with histological grading more accurately predicted malignant transformation (p=0.005) than histology alone and correctly predicted malignant transformation in 10/17 initial biopsies. Significantly reduced expression of total FANCD2, pFANCD2, pATR, pCHK-1 and pFANCG were observed in unstable OED. Discussion: There is good evidence that defects in the DNA damage sensing-signalling-repair cascade are associated with malignant transformation in OED. Loss of post-translational modification in FANCD2 and related proteins, was more predictive of malignant transformation when compared to clinicopathological parameters.

scholarly journals Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia

2020 ◽  
Author(s):  
Michael W Ho ◽  
Mark Ryan ◽  
Juhi Gupta ◽  
Asterios Triantafyllou ◽  
Janet Risk ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Tissue Sample ◽  
Good Evidence ◽  
Epithelial Dysplasia ◽  
Clinicopathological Parameters ◽  
Post Translational Modification ◽  
Oral Epithelial Dysplasia ◽  
Damage Sensing ◽  
Related Proteins ◽  
Oral Epithelial

Abstract Background: Predicting malignant transformation in oral epithelial dysplasia(OED) is a clinical challenge. The higher rate of malignant transformation in non-smokers supports an endogenous aetiology. Loss of FANCD2 and associated proteins could lead to genomic instability and oncogenesis.Methods: Longitudinal archival samples from 40 individuals with OED from time of diagnosis to the most recent review in 23 stable OED; or until excision of the SCC in 17 unstable OED undergoing malignant transformation. Histopathological reassessment, immunohistochemistry for FANCD2 and Western blotting for phosphorylation/monubiquitination status of ATR, CHK1, FANCD2 and FANCG were undertaken on each tissue sample.Results: Decreased expression of FANCD2 was observed in the diagnostic biopsy of OED lesions which later underwent malignant transformation. Combining the FANCD2 expression scores with histological grading more accurately predicted malignant transformation (p=0.005) than histology alone and correctly predicted malignant transformation in 10/17 initial biopsies. Significantly reduced expression of total FANCD2, pFANCD2, pATR, pCHK-1 and pFANCG were observed in unstable OED.Discussion: There is good evidence that defects in the DNA damage sensing-signalling-repair cascade are associated with malignant transformation in OED. Loss of post-translational modification in FANCD2 and related proteins, was more predictive of malignant transformation when compared to clinicopathological parameters.

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