Myoepithelial carcinoma of the minor salivary glands: A case report of a rare tumor

Abstract Introduction/Objective Myoepithelial carcinoma is identified by nearly exclusive myoepithelial differentiation and evidence of malignancy. It may arise de novo or in preexisting benign tumors including pleomorphic adenoma and benign myoepithelioma. It occurs most commonly in the parotid gland followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Nasopharyngeal origin has been rarely reported. Methods/Case Report An afebrile 19-year-old female presented to the emergency department with persistent facial pressure, otalgia (right side greater than left side), rhinorrhea, and several episodes of epistaxis. One month before, she has been treated with Amoxicillin for three days with no relief, where Augmentin started for her for five days. About four days prior presentation, she was placed on Prednisone and Cefdinir. Over the next several days, she began having throat pain with difficulty swallowing. Routine blood work revealed a leukocytosis of 14.2 with normal differentiation. CT of the neck showed a large soft tissue mass centered at the right nasopharynx. Flexible nasal endoscopy performed bilaterally to reveal the nasopharynx is entirely obstructed with a lobulated mass filling the nasopharynx. On the right side, it extends into the posterior nasal passage filling the sphenoethmoid recess and the posterior floor of the nasal passage. Outpatient biopsy from nasopharynx mass is also performed. Results (if a Case Study enter NA) Mass biopsy reveals a mucinous and chondromyxoid background with mixed epithelial and myoepithelial differentiation. The is squamous metaplasia of myoepithelial cells and prominent mitotic activity and apoptotic activity. Immunohistochemistry was positive for CK5/6, calponin, BCL2, SMA, BerEp4, Sox10, and a proliferative index up to 40%. Based on this information Myoepithelial Carcinoma ex-pleomorphic adenoma of the nasopharynx is the diagnosis. Conclusion Carcinoma ex pleomorphic adenoma is usually a high-grade malignancy. It occurs most commonly in the parotid gland, followed by submandibular glands, minor salivary glands, and occasionally in the sublingual gland. Our case is one of the few cases of myoepithelial carcinoma arising in nasopharyngeal pleomorphic adenoma.

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Mucoepidermoid Carcinoma of Palatal Minor Salivary Glands with Intracranial Extension: A Case Report and Literature Review

Journal of Neurological Surgery Reports ◽

10.1055/s-0036-1593396 ◽

2016 ◽

Vol 77 (04) ◽

pp. e156-e159 ◽

Cited By ~ 2

Author(s):

Rimal Dossani ◽

Hesam Akbarian-Tefaghi ◽

Lori Lemonnier ◽

Vikas Mehta ◽

Jamie Jacobsohn ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Salivary Glands ◽

Mucoepidermoid Carcinoma ◽

Intracranial Extension ◽

Minor Salivary Glands

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Pleomorphic Adenoma of the Cervical Heterotopic Salivary Gland: A Case Report

Case Reports in Otolaryngology ◽

10.1155/2012/470652 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 2

Author(s):

Saman Vegari ◽

Masoud Naderpour ◽

Alireza Hemmati ◽

Hosein Baybordi

Keyword(s):

Salivary Gland ◽

Case Report ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Complete Resection ◽

Cervical Region ◽

Minor Salivary Glands ◽

Pathologic Evaluation ◽

Painless Mass

Introduction. Although pleomorphic adenoma is the most common neoplasm of the salivary glands, this tumor most commonly involves the minor salivary glands of palatal and rarely occurs in cervical region.Case Report. A 21-year-old female referred to our clinic due to painless mass of right upper region of neck. After paraclinical and pathologic evaluation, it was diagnosed as cervical pleomorphic adenoma.Conclusion. Pleomorphic adenoma may be rarely involving the neck. Although the prognosis is good, the choice treatment is the complete resection of the tumor.

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ADENOID CYSTIC CARCINOMA OF MINOR SALIVARY GLANDS: CASE REPORT

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2019.06.333 ◽

2020 ◽

Vol 129 (1) ◽

pp. e82

Author(s):

CAMILA OLIVEIRA SANTOS ◽

ALYNE AMORIM DE ARAÚJO ◽

RODRIGO RESENDE ◽

VANIA DO CARMO ◽

LUISA AGUIRRE BUEXM ◽

...

Keyword(s):

Case Report ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature

Allergy & Rhinology ◽

10.1177/2152656719889030 ◽

2019 ◽

Vol 10 ◽

pp. 215265671988903 ◽

Cited By ~ 1

Author(s):

Madison J. Malfitano ◽

Meghan N. Norris ◽

Wesley H. Stepp ◽

Griffin D. Santarelli ◽

T. Danielle Samulski ◽

...

Keyword(s):

Case Report ◽

Salivary Glands ◽

Clear Cell ◽

Malignant Tumors ◽

Treatment Strategies ◽

Low Grade ◽

Minor Salivary Glands ◽

Presenting Symptoms ◽

Nasopharyngeal Mass ◽

The Right

Background Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx. Methods A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Results A 48-year-old man underwent biopsy of a 4.5 cm mass of the right nasopharynx with pathology suggesting an intermediate grade mucoepidermoid carcinoma. After discussing management with the patient, an endoscopic resection was performed. Final pathology revealed an HCCC which was confirmed after negative Mastermind-like 2 (MAML2) and positive Ewing sarcoma breakpoint region 1 (ESWR1) gene rearrangements on fluorescence in situ hybridization (FISH) studies. Literature review of other nasopharyngeal HCCC cases shows diverse presentation and overall excellent prognosis through surgical and radiation therapy. Conclusion HCCCs are rare, low-grade malignant tumors of the minor salivary glands and can present as a nasopharyngeal mass. Presenting symptoms are diverse but frequently involve otologic and sinonasal disturbances. HCCC is an indolent tumor with an excellent prognostic outcome when treated appropriately with surgical resection and adjuvant radiotherapy.

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A Giant Pleomorphic Adenoma of the Palatine Arch in a 75-Year-Old Man: A Case Report with Review of Literature

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1213 ◽

2015 ◽

Vol 6 (1) ◽

pp. 23-25

Author(s):

Santosh Kumar Swain ◽

Mahesh Chandra Sahu ◽

Rajashree Tripathy

Keyword(s):

Case Report ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Soft Palate ◽

Benign Tumor ◽

Review Of Literature ◽

Minor Salivary Glands ◽

Common Benign Tumor ◽

Slow Growing ◽

Head Neck

ABSTRACT Pleomorphic adenoma (PA) is the most common benign tumor of the salivary glands and has both epithelial and mesenchymal tissues. It most commonly arises from the parotid or submandibular glands. Rarely, it arises from the minor salivary glands. We report here a case of pleomorphic adenoma arising from the soft palate and both sides of anterior tonsillar pillars in a 75-year-old man. This patient was presenting painless slow growing large swelling in the soft palate over 20 years causing mechanical obstruction of airway and food. The entire tumor mass was excised along with overlying mucosa. How to cite this article Swain SK, Sahu MC, Tripathy R. A Giant Pleomorphic Adenoma of the Palatine Arch in a 75-Year-Old Man: A Case Report with Review of Literature. Int J Head Neck Surg 2015;6(1):23-25.

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