Intraneural injection of interleukin-1β and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain

Pain ◽  
2005 ◽  
Vol 116 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Marek Zelenka ◽  
Maria Schäfers ◽  
Claudia Sommer
Keyword(s):  
Neuropathic Pain ◽  
Tumor Necrosis Factor ◽  
Sciatic Nerve ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Interleukin 1Β ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Intraneural Injection ◽  
Necrosis Factor

scholarly journals The Treponema denticola Surface Protease Dentilisin Degrades Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor Alpha

2006 ◽  
Vol 74 (4) ◽  
pp. 2462-2467 ◽  
Author(s):  
Meguru Miyamoto ◽  
Kazuyuki Ishihara ◽  
Katsuji Okuda
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Mononuclear Cells ◽  
Interleukin 1Β ◽  
Treponema Denticola ◽  
Peripheral Blood Mononuclear ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

ABSTRACT Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentilisin.

Discovery of Novel 1,2,4-Triazol-5-Ones as Tumor Necrosis Factor-Alpha Inhibitors for the Treatment of Neuropathic Pain

2012 ◽  
Vol 80 (6) ◽  
pp. 961-970 ◽  
Author(s):  
Monika Sharma ◽  
Sowmya Garigipati ◽  
Binita Kundu ◽  
Deekshith Vanamala ◽  
Arvind Semwal ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
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