The influence of ovariectomy on anti-convulsant effect of pioglitazone in mice

2015 ◽  
Vol 22 (3) ◽  
pp. 159-163 ◽  
Author(s):  
Leila Moezi ◽  
Mahsa Hassanipour ◽  
Meysam Zaeri ◽  
Hassan Ghorbani ◽  
Hamed Shafaroodi
Keyword(s):  
Convulsant Effect

On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock

1980 ◽  
Vol 19 (10) ◽  
pp. 1017-1023 ◽  
Author(s):  
D.J. Nutt ◽  
P.J. Cowen ◽  
A.R. Green
Keyword(s):  
Electroconvulsive Shock ◽  
Convulsant Effect

Brain Respiration and Glycolysis in Cardiazol Convulsions

1940 ◽  
Vol 86 (361) ◽  
pp. 276-280 ◽  
Author(s):  
Leslie Dundonald MacLeod ◽  
Max Reiss
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Direct Action ◽  
Reducing Power ◽  
Liver Glycogen ◽  
Potassium Ions ◽  
Blood Picture ◽  
The Central Nervous System ◽  
Respiratory Centre ◽  
Convulsant Effect

Since Hildebrandt (1926) described the convulsant effect of cardiazol injection, several studies have been carried out on the mechanism of such convulsions. Zung and Tremonti (1931) suggested a direct action on the respiratory centre when cardiazol is used as a stimulant; Kerr and Antaki (1937) found no effect on brain glycogen or phosphocreatine in cardiazol-induced convulsions; Hashimoto (1937) found differences in distribution of calcium and potassium ions in the central nervous system after cardiazol. Goodwin and Lloyd (1938) recorded a direct effect on brain potential changes as shown on oscillographic records. Leibel and Hall (1938) found a large (75 per cent.) diminution of cerebral blood-flow at the onset of cardiazol convulsions. Weigand (1938) found no effect on liver glycogen or vitamin A content, reducing power of suprarenal cortex or blood picture. Denyssen and Watterson (1938) and Watterson and Macdonald (1939) attribute the convulsions to action on the vasomotor centre and note the action of vasodilator drugs in inhibiting convulsions. Wortis (1938) quoted by Quastel (1939) found no effect on brain respiration.

scholarly journals Anticonvulsant Activity of the Linalool Enantiomers and Racemate: Investigation of Chiral Influence

2010 ◽  
Vol 5 (12) ◽  
pp. 1934578X1000501 ◽  
Author(s):  
Damião P. de Sousa ◽  
Franklin F. F. Nóbrega ◽  
Camila C. M. P. Santos ◽  
Reinaldo N. de Almeida
Keyword(s):  
Pharmacological Activity ◽  
Anticonvulsant Activity ◽  
The Other ◽  
Racemic Mixture ◽  
Maximum Effect ◽  
Other Hand ◽  
Tonic Extension ◽  
Seizure Model ◽  
Convulsant Effect

The anticonvulsant activity of the racemate and enantiomers of linalool have been evaluated. Pretreatment of the mice with ( S)-(+)-, ( R)-(-)- and rac-linalool increased the latency of convulsions significantly in the PTZ model. Only rac-linalool had an effect at the dose of 200 mg/kg. The enantiomers and their racemic mixture were effective in inhibiting the convulsant effect of PTZ at the dose of 300 mg/kg. The linalools presented pharmacological activity close to that of diazepam. In the PIC seizure model, ( R)-(-)-linalool and rac-linalool presented activity at the dose of 200 mg/kg, but the rac-linalool was more potent than ( R)-(-)-linalool; ( S)-(+)-linalool had no effect at this dose. On the other hand, at the dose of 300 mg/kg this enantiomer was effective, but less potent than ( R)-(-)-linalool and rac-linalool. In the MES model, linalools decreased the convulsion time of the mice in the doses of 200 and 300 mg/kg. rac-Linalool presented maximum effect at 300 mg/kg. Surprisingly, it increased significantly the convulsion time at a dose of 100 mg/kg. Using the parameter of tonic hind convulsions, only ( R)-(-)-linalool produced protection from tonic extension at the dose of 200 mg/kg. When the (+)- and (-)-enantiomers, and rac-linalool were administered at the dose of 300 mg/kg they were also effective in preventing tonic convulsions induced by transcorneal electroshock in the animals. The (+)- and (-)-forms were equipotent and the rac-linalool was more effective than phenytoin. We have demonstrated that the two enantiomers have similar qualitative anticonvulsant activity, but show different potencies.

2,3-Butanedione monoxime protects mice against the convulsant effect of picrotoxin by facilitating GABA-activated currents

1995 ◽  
Vol 678 (1-2) ◽  
pp. 110-116 ◽  
Author(s):  
Tracy Brightman ◽  
Jiang-Hong Ye ◽  
Elizabeth Ortiz-Jimenez ◽  
Edward J. Flynn ◽  
Wen-Hsien Wu ◽  
...  
Keyword(s):  
Butanedione Monoxime ◽  
Convulsant Effect

Effect of naloxone on ethanol- and pentobarbital-induced narcosis

1982 ◽  
Vol 60 (10) ◽  
pp. 1315-1318 ◽  
Author(s):  
J. M. Khanna ◽  
J. M. Mayer ◽  
H. Kalant ◽  
G. Shah
Keyword(s):  
Sleep Duration ◽  
Low Doses ◽  
Small Reduction ◽  
High Doses ◽  
Higher Doses ◽  
Convulsant Effect

Single or repeated subcutaneous administrations of naloxone in doses of up to 4 mg∙kg−1 did not alter the time for onset or the duration of ethanol- or pentobarbital-induced narcosis in rats. An increase in the naloxone dosage to 50 mg∙kg−1 s.c. resulted in a small reduction of ethanol-induced sleep duration. Repeated i.p. or i.v. administrations of much higher doses of naloxone (300–400 mg∙kg−1 and 120–180 mg∙kg−1, respectively) did produce significant reductions in ethanol-induced narcosis. However, similar naloxone doses, when administered alone, i.v., had marked convulsant effect. It appears that naloxone, in low doses, is not an effective antidote for narcosis caused by ethanol or pentobarbital at the ethanol and pentobarbital doses tested, whereas the antagonism of ethanol-induced sleep by high doses of naloxone may be due to the analeptic action of this drug.

Convulsant effect of l-glutamic acid-γ-hydrazide by simultaneous treatment with pyridoxal phosphate

1964 ◽  
Vol 13 (1) ◽  
pp. 118-120 ◽  
Author(s):  
Guillermo H. Massieu ◽  
Ricardo Tapia I. ◽  
Herminia Pasantes O. ◽  
Berta G. Ortega
Keyword(s):  
Glutamic Acid ◽  
Pyridoxal Phosphate ◽  
Simultaneous Treatment ◽  
Convulsant Effect

CONVULSANT EFFECT OF PENICILLIN

The Lancet ◽  
1963 ◽  
Vol 281 (7276) ◽  
pp. 328
Author(s):  
A.E. Wilder Smith
Keyword(s):  
Convulsant Effect

scholarly journals ANTI-CONVULSANT EFFECT OF PHTHALAZINO-2,3b-PHTHALAZINE-5(14H),12(7H)-DIONE (L-5418). I. BEHAVIORAL EFFECT

1978 ◽  
Vol 28 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Koichiro GO ◽  
Kaito TSURUMI ◽  
Hajime FUJIMURA
Keyword(s):  
Behavioral Effect ◽  
Convulsant Effect

ANTI CONVULSANT EFFECT OF NIFEDIPINE, DIAZEPAM AND IN COMBINATION ON MES INDUCED EPILEPSY IN RATS

2017 ◽  
Vol 3 (4) ◽  
pp. 22 ◽  
Author(s):  
MURALIDHAR C ◽  
SRIDHAR INUGURTHY ◽  
KAVITHA MUDAVATH
Keyword(s):  
Convulsant Effect
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