Concurrent thymic squamous cell carcinoma and disseminated intravascular large B-cell lymphoma. A previously unreported association

Abstract Background The collision tumor consisted of two malignant tumors that independently developed and were contiguous or had invaded each other. Among the reports of malignant collision tumors, collision tumors consisting of lung cancer and malignant lymphoma are extremely rare. We report case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma.Case presentationA 74-year-old man was admitted to the hospital due to identification of an abnormal nodular shadow in the right upper lobe on chest computed tomography following a chest X-ray. At the time of admission, a swollen lymph node of 7 cm × 5 cm was palpated in the left neck, and serum examination showed an abnormally high level of soluble interleukin-2 receptor. Close examination led to a diagnosis of stage IA squamous cell carcinoma of the lung and stage IVA malignant lymphoma, and treatment for the malignant lymphoma was prioritized. However, due to progression of lung cancer, a right upper lobectomy with lymph node dissection was performed. Pathological findings showed that squamous cell carcinoma and malignant lymphoma were both present in the same lesion.ConclusionOnly two cases of collision tumors consisting of malignant lymphoma and primary lung cancer were reported [1] [2] and this case is considered to be the third rare case in the world. As the rate of complications with other malignancies in patients with diffuse large B-cell lymphoma is high, in the case of advanced stage malignant lymphoma, physicians must consider which treatment should be prioritized according to the degree of progression of coexisting solid tumors.

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Cervical Lymph Node Collision Tumor Consisting of Metastatic Squamous Cell Carcinoma and B-Cell Lymphoma

The Laryngoscope ◽

10.1002/lary.21620 ◽

2010 ◽

Vol 120 (S4) ◽

pp. S156-S156 ◽

Cited By ~ 3

Author(s):

Kiran Kakarala ◽

Peter M. Sadow ◽

Kevin S. Emerick

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

B Cell ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cervical Lymph Node ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Collision Tumor ◽

Metastatic Squamous Cell Carcinoma

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Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical approach

Wiener Medizinische Wochenschrift ◽

10.1007/s10354-016-0510-x ◽

2016 ◽

Vol 167 (5-6) ◽

pp. 104-109

Author(s):

Uwe Wollina ◽

Jacqueline Schönlebe ◽

Birgit Heinig ◽

Andreas Nowak ◽

Anastasiya Atanasova Chokoeva ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

B Cell ◽

Cell Carcinoma ◽

Squamous Cell ◽

Surgical Approach ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Rare Association

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Intravascular Large B-Cell Lymphoma and Renal Clear Cell Carcinoma as Collision Tumor: A Case Report and Review of the Literature

International Journal of Surgical Pathology ◽

10.1177/1066896920981633 ◽

2020 ◽

pp. 106689692098163

Author(s):

Alejandra Griselda Serrano ◽

Boris Elsner ◽

Maria Cecilia Cabral Lorenzo ◽

Fabio Andres Morales Clavijo

Keyword(s):

B Cell ◽

Cell Carcinoma ◽

Clear Cell ◽

Cell Lymphoma ◽

Systemic Disease ◽

Performance Status ◽

B Cell Lymphoma ◽

Collision Tumor ◽

Large B Cell Lymphoma ◽

Large B Cell

Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of vessels. The patient usually presents with nonspecific symptoms and a remarkable deterioration in performance status. The occurrence of synchronous IVLBCL and renal cell carcinoma (RCC) is extremely rare. A right kidney tumor was found in a 72-year-old man with a history of low back pain. The kidney was enlarged, with a tumor mass measuring 4.5 × 4 × 4 cm. Sections exhibited a RCC (clear cell type, nuclear grade I). Also an extensive tumor affecting capillaries and small veins was present, positive for CD45, CD20, BCL-2, and MUM1/IRF-4, consistent with IVLBCL. The lymphoma was circumscribed to the RCC. The final diagnosis was IVLBCL with a RCC as collision tumor. After that, with neurological findings, central nervous system compromise by lymphoma was made. The patient started a first cycle of chemotherapy, progressive deterioration of the sensorium, and positive blood cultures for Klebsiella pneumoniae and Escherichia coli. The patient died 8 days later of acute respiratory failure. No autopsy was done. IVLBCL is an aggressive and systemic disease characterized by massive proliferation of tumor cells without a known primary site. Clinical identification and histopathologic diagnosis are relevant issues in the therapeutic management of these lymphomas. Until now, only one case of IVLBCL coexisting with RCC has been reported. In this article, we report a second case of IVLBCL with RCC simultaneous, as an unusual collision tumor.

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