scholarly journals Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma

2021 ◽  
Author(s):  
Masato SASAKI ◽  
Kayo SAKON ◽  
Kaede TANAKA ◽  
Tae MIZUNAGA ◽  
Keita YANO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Malignant Lymphoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Collision Tumor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract Background The collision tumor consisted of two malignant tumors that independently developed and were contiguous or had invaded each other. Among the reports of malignant collision tumors, collision tumors consisting of lung cancer and malignant lymphoma are extremely rare. We report case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B-cell lymphoma.Case presentationA 74-year-old man was admitted to the hospital due to identification of an abnormal nodular shadow in the right upper lobe on chest computed tomography following a chest X-ray. At the time of admission, a swollen lymph node of 7 cm × 5 cm was palpated in the left neck, and serum examination showed an abnormally high level of soluble interleukin-2 receptor. Close examination led to a diagnosis of stage IA squamous cell carcinoma of the lung and stage IVA malignant lymphoma, and treatment for the malignant lymphoma was prioritized. However, due to progression of lung cancer, a right upper lobectomy with lymph node dissection was performed. Pathological findings showed that squamous cell carcinoma and malignant lymphoma were both present in the same lesion.ConclusionOnly two cases of collision tumors consisting of malignant lymphoma and primary lung cancer were reported [1] [2] and this case is considered to be the third rare case in the world. As the rate of complications with other malignancies in patients with diffuse large B-cell lymphoma is high, in the case of advanced stage malignant lymphoma, physicians must consider which treatment should be prioritized according to the degree of progression of coexisting solid tumors.

scholarly journals A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma

2018 ◽  
Vol 93 (3) ◽  
pp. 300-305 ◽  
Author(s):  
Seung Jae Lee ◽  
Si Young Lim ◽  
Tae Kyung Yoo ◽  
Seul Ki Kim ◽  
You Gyung Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
Lung Squamous Cell Carcinoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals A Case of Rectal Squamous Cell Carcinoma with Metachronous Diffuse Large B Cell Lymphoma in an HIV-Infected Patient

2014 ◽  
Vol 46 (4) ◽  
pp. 257 ◽  
Author(s):  
Heun Choi ◽  
Hye Won Lee ◽  
Hea Won Ann ◽  
Jae Kyung Kim ◽  
Hua Pyong Kang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Infected Patient ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Synchronous squamous cell carcinoma and diffuse large B-cell lymphoma of the head and neck: the odd couple

2016 ◽  
Vol 2 (1) ◽  
pp. 20150271
Author(s):  
Ann C Raldow ◽  
Johann G Brown ◽  
Nicole Chau ◽  
Matthew S Davids ◽  
Danielle N Margalit ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Intravascular Large B-Cell Lymphoma and Renal Clear Cell Carcinoma as Collision Tumor: A Case Report and Review of the Literature

2020 ◽  
pp. 106689692098163
Author(s):  
Alejandra Griselda Serrano ◽  
Boris Elsner ◽  
Maria Cecilia Cabral Lorenzo ◽  
Fabio Andres Morales Clavijo
Keyword(s):  
B Cell ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Cell Lymphoma ◽  
Systemic Disease ◽  
Performance Status ◽  
B Cell Lymphoma ◽  
Collision Tumor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma characterized by the selective growth of lymphoma cells within the lumina of vessels. The patient usually presents with nonspecific symptoms and a remarkable deterioration in performance status. The occurrence of synchronous IVLBCL and renal cell carcinoma (RCC) is extremely rare. A right kidney tumor was found in a 72-year-old man with a history of low back pain. The kidney was enlarged, with a tumor mass measuring 4.5 × 4 × 4 cm. Sections exhibited a RCC (clear cell type, nuclear grade I). Also an extensive tumor affecting capillaries and small veins was present, positive for CD45, CD20, BCL-2, and MUM1/IRF-4, consistent with IVLBCL. The lymphoma was circumscribed to the RCC. The final diagnosis was IVLBCL with a RCC as collision tumor. After that, with neurological findings, central nervous system compromise by lymphoma was made. The patient started a first cycle of chemotherapy, progressive deterioration of the sensorium, and positive blood cultures for Klebsiella pneumoniae and Escherichia coli. The patient died 8 days later of acute respiratory failure. No autopsy was done. IVLBCL is an aggressive and systemic disease characterized by massive proliferation of tumor cells without a known primary site. Clinical identification and histopathologic diagnosis are relevant issues in the therapeutic management of these lymphomas. Until now, only one case of IVLBCL coexisting with RCC has been reported. In this article, we report a second case of IVLBCL with RCC simultaneous, as an unusual collision tumor.

scholarly journals Collision Tumor Comprising Primary Malignant Lymphoma and Adenocarcinoma in the Ascending Colon

2021 ◽  
pp. 379-388
Author(s):  
Jun Kataoka ◽  
Toshikatsu Nitta ◽  
Masato Ota ◽  
Kensuke Fujii ◽  
Masatsugu Ishii ◽  
...  
Keyword(s):  
Lymph Node ◽  
B Cell ◽  
Malignant Lymphoma ◽  
Cell Lymphoma ◽  
Muscularis Propria ◽  
B Cell Lymphoma ◽  
Collision Tumor ◽  
Ascending Colon ◽  
Large B Cell Lymphoma ◽  
Large B Cell

We describe the case of a 78-year-old man with collision tumor from the primary malignant lymphoma and adenocarcinoma in the ascending colon. He suffered anemia from sigmoid colon cancer, and colonoscopy revealed early-stage colorectal cancer with a diameter of 20 mm in the cecum, the biopsy specimen showed moderately differentiated adenocarcinoma. Contrast-enhanced computed tomography (CT) revealed bowel wall thickening with contrast enhancement at the cecum; however, no lymph node and organ metastases were found. As above, we performed laparoscopic ileocecal resection with D3 lymph node dissection. The postoperative course was uneventful, and he was discharged from the hospital on postoperative day 11. Histopathological findings were moderately differentiated adenocarcinoma which invaded the muscularis propria and serosa from the submucosa, while the adjacent serosa showed a highly diffuse proliferation of atypical cells with an irregular nuclear-to-cytoplasmic ratio. Besides, immunohistochemical staining findings were diffuse large B-cell lymphoma, and diffuse large B-cell lymphoma was coexistent with moderately differentiated adenocarcinoma. We treated the patient with cyclophosphamide, doxorubicin, vincristine, and prednisolone in combination with rituximab (R-CHOP therapy) during 3 months postoperatively. When the 8 courses had been completed, postoperative positron emission tomography-CT (PET-CT) confirmed complete response, and the disease control has been doing well. Malignant lymphoma of the colorectal region is relative rare, and the occurrence of synchronous lymphoma and adenocarcinoma of the colon is also rare. Furthermore, collision tumor by these different entities is very unusual. We presented here such a case. The accurate clinical determination of the dominant tumor and a close follow-up is required for proper treatment in these cases.

scholarly journals Primary Type3 (Non-ABC, Non-GCB) Subtype of Extranodal Diffuse Large B-Cell Lymphoma of the Thyroid Bearing No MYD88 Mutation by Padlock Probe Hybridization

2017 ◽  
Vol 10 (2) ◽  
pp. 508-514 ◽  
Author(s):  
Yukiko Nishi ◽  
Riko Kitazawa ◽  
Ryuma Haraguchi ◽  
Ayaka Ouchi ◽  
Yasuo Ueda ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Malignant Lymphoma ◽  
Cell Lymphoma ◽  
Clinical Phenotype ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Japanese Female ◽  
Old Japanese ◽  
Large B Cell

Primary extranodal malignant lymphoma of the thyroid is a rare entity composed of mostly neoplastic transformation of germinal center-like B cells (GCB) or memory B cells. Other B-cell-type malignancies arising primarily in the thyroid have rarely been described. Immunohistochemical examination of autopsied primary malignant lymphoma of the thyroid in an 83-year-old Japanese female revealed the presence of a non-GCB subtype of diffuse large B-cell lymphoma (DLBCL) without the typical codon 206 or 265 missense mutation of MYD88. The lack of the highly oncogenic MYD88 gene mutation, frequently observed in DLBCL of the activated B-cell (ABC) subtype, and the detection of an extremely aggressive yet local clinical phenotype demonstrated that the present case was an exceptional entity of the type3 (non-GCB and non-ABC) subtype.

scholarly journals Relative Frequencies and Patterns of Malignant Lymphoma in a Reference Centre in Khartoum, Sudan: A Descriptive Study Based on the WHO Classification of Lymphoid Neoplasms

2020 ◽  
Vol 5 (2) ◽  
pp. 107-112
Author(s):  
Ezeldine K Abdalhabib
Keyword(s):  
B Cell ◽  
Malignant Lymphoma ◽  
Complete Blood Count ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Reference Centre ◽  
Large B Cell Lymphoma ◽  
Appropriate Treatment ◽  
Age Range ◽  
Large B Cell

Background: The effective management and choice of appropriate treatment of lymphoma subtypes depend on an accurate diagnosis and differentiation, which require comprehensive haematology and pathology work. Methods: A total of 134 cases of malignant lymphoma, newly diagnosed between January 2017 to January 2020, were selected. For each patient’s samples, complete blood count, immunohistochemistry, and morphological evaluation were done. Results: Clinical data showed that 81 patients (60.4%) were males and 53 (39.6%) females. The age range was 4 to 80 years. NHL lymphoma comprised 87.3% of cases, while HL comprised 12.7% of cases. Diffuse large B cell lymphoma was the most prevalent NHL subtype, representing 39.3% of cases. Among HL subtypes, mixed cellularity was present in 41.2% of cases. B cell lymphoma constituted 93.2% of cases. All HL patients and 74.4% of NHL patients had anaemia. Conclusion: This is the first statistical report of malignant lymphoma patterns in Sudanese patients. These data suggest that malignant lymphoma in Sudanese patients is more frequent in males than females; its incidence increases with age. Further, B cell lymphoma is more common than T cell lymphoma. Diffuse large B cell lymphoma was the most frequent NHL subtype.

Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical approach

2016 ◽  
Vol 167 (5-6) ◽  
pp. 104-109
Author(s):  
Uwe Wollina ◽  
Jacqueline Schönlebe ◽  
Birgit Heinig ◽  
Andreas Nowak ◽  
Anastasiya Atanasova Chokoeva ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
B Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Approach ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Rare Association
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