Opioid receptor types involved in the development of nicotine physical dependence in an invertebrate (Planaria) model

2013 ◽  
Vol 112 ◽  
pp. 9-14 ◽  
Author(s):  
Robert B. Raffa ◽  
Steve Baron ◽  
Jaspreet S. Bhandal ◽  
Tevin Brown ◽  
Kevin Song ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Physical Dependence ◽  
Opioid Receptor Types

Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig heal longitudinal muscle

1994 ◽  
Vol 33 (5) ◽  
pp. 671-679 ◽  
Author(s):  
M. Ozaki ◽  
Y. Miyamoto ◽  
S. Kishioka ◽  
Y. Masuda ◽  
H. Yamamoto
Keyword(s):  
Guinea Pig ◽  
Opioid Receptor ◽  
Longitudinal Muscle ◽  
Opioid Receptor Types

scholarly journals Analgesic Activity of the Kappa Opioid Receptor Agonist RU-1205 in Rats

2018 ◽  
Vol 3 (2) ◽  
pp. 13 ◽  
Author(s):  
AA Spasov ◽  
OY Grechko ◽  
DM Shtareva ◽  
AI Raschenko ◽  
Natalia Eliseeva ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Analgesic Activity ◽  
Analgesic Effect ◽  
Physical Dependence ◽  
Receptor Activation ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Plate Test

Introduction: Opioid analgesics are the most efficient and widely used drugs for the management of moderate to severe pain. However, side effects associated with mu receptor activation, such as respiratory depression, tolerance and physical dependence severely limit their clinical application. Currently, the kappa-opioid system is the most attractive in terms of the clinical problem of pain, because kappa-agonists do not cause euphoria and physical dependence. The purpose of this study was to evaluate the antinociceptive effect of the novel compound - RU-1205. Methods: The analgesic activity of RU-1205 was studied on nociceptive models that characterize the central and peripheral pathways of pain sensitivity (hot plate test, electrically induced vocalisation, formalin test, writhing test). Results: RU-1205 exhibited highly potent antinociceptive effects in rodent models of acute pain with ED50 values of 0.002 - 0.49 mg /kg. Pretreatment with the κ-opioid receptor antagonist norBinaltorphimine significantly attenuated the analgesic activity of investigated substance in a hot plate test. Conclusions: It was established that the compound shows a significant dose-dependent central and peripheral analgesic effect. It was assumed kappa-opioidergic mechanism of analgesic effect of RU-1205.

A novel κ-opioid receptor agonist, TRK-820, blocks the development of physical dependence on morphine in mice

Life Sciences ◽  
2000 ◽  
Vol 66 (25) ◽  
pp. PL353-PL358 ◽  
Author(s):  
Minoru Tsuji ◽  
Hiroshi Takeda ◽  
Teruhiko Matsumiya ◽  
Hiroshi Nagase ◽  
Mitsuaki Yamazaki ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Physical Dependence ◽  
Opioid Receptor Agonist
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