Depression of home cage wheel running is an objective measure of spontaneous morphine withdrawal in rats with and without persistent pain

Use of home cage wheel running to assess the behavioural effects of administering a mu/delta opioid receptor heterodimer antagonist for spontaneous morphine withdrawal in the rat

Behavioural Brain Research ◽

10.1016/j.bbr.2020.112953 ◽

2021 ◽

Vol 397 ◽

pp. 112953

Author(s):

Michael M. Morgan ◽

Danielle L. Peecher ◽

John M. Streicher

Keyword(s):

Opioid Receptor ◽

Home Cage ◽

Wheel Running ◽

Morphine Withdrawal ◽

Delta Opioid Receptor ◽

Behavioural Effects

Persistent Pain Maintains Morphine-Seeking Behavior after Morphine Withdrawal through Reduced MeCP2 Repression of Glua1 in Rat Central Amygdala

Journal of Neuroscience ◽

10.1523/jneurosci.3453-14.2015 ◽

2015 ◽

Vol 35 (8) ◽

pp. 3689-3700 ◽

Cited By ~ 22

Author(s):

Y.-Y. Hou ◽

Y.-Q. Cai ◽

Z. Z. Pan

Keyword(s):

Persistent Pain ◽

Morphine Withdrawal ◽

Central Amygdala ◽

Seeking Behavior

Home cage wheel running is an objective and clinically relevant method to assess inflammatory pain in male and female rats

Journal of Neuroscience Methods ◽

10.1016/j.jneumeth.2016.02.013 ◽

2016 ◽

Vol 263 ◽

pp. 115-122 ◽

Cited By ~ 36

Author(s):

Ram Kandasamy ◽

Jonas J. Calsbeek ◽

Michael M. Morgan

Keyword(s):

Inflammatory Pain ◽

Home Cage ◽

Wheel Running ◽

Female Rats ◽

Male And Female ◽

Male And Female Rats

Influence of corticosterone on growth, home-cage activity, wheel running, and aerobic capacity in house mice selectively bred for high voluntary wheel-running behavior

Physiology & Behavior ◽

10.1016/j.physbeh.2018.10.001 ◽

2019 ◽

Vol 198 ◽

pp. 27-41 ◽

Cited By ~ 7

Author(s):

Jennifer M. Singleton ◽

Theodore Garland

Keyword(s):

Aerobic Capacity ◽

Home Cage ◽

Wheel Running ◽

Activity Wheel ◽

House Mice ◽

Voluntary Wheel Running ◽

Cage Activity ◽

Home Cage Activity ◽

Voluntary Wheel

Analysis of inflammation-induced depression of home cage wheel running in rats reveals the difference between opioid antinociception and restoration of function

Behavioural Brain Research ◽

10.1016/j.bbr.2016.10.024 ◽

2017 ◽

Vol 317 ◽

pp. 502-507 ◽

Cited By ~ 13

Author(s):

Ram Kandasamy ◽

Jonas J. Calsbeek ◽

Michael M. Morgan

Keyword(s):

Home Cage ◽

Wheel Running ◽

The Difference ◽

Opioid Antinociception

Total home-cage activity as a function of the estrous cycle and wheel running in the rat

Psychonomic Science ◽

10.3758/bf03332549 ◽

1971 ◽

Vol 22 (3) ◽

pp. 164-165 ◽

Cited By ~ 4

Author(s):

Wilmar A. Jennings

Keyword(s):

Estrous Cycle ◽

Home Cage ◽

Wheel Running ◽

Cage Activity ◽

Home Cage Activity

Social housing promotes recovery of wheel running depressed by inflammatory pain and morphine withdrawal in male rats

Behavioural Brain Research ◽

10.1016/j.bbr.2020.112912 ◽

2021 ◽

Vol 396 ◽

pp. 112912

Author(s):

Jonah D. Stickney ◽

Michael M. Morgan

Keyword(s):

Social Housing ◽

Inflammatory Pain ◽

Wheel Running ◽

Morphine Withdrawal ◽

Male Rats

Erratum to “Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion” [Behav. Brain Res. 160 (2005) 382–388]

Behavioural Brain Research ◽

10.1016/j.bbr.2005.05.001 ◽

2005 ◽

Vol 163 (1) ◽

pp. 141

Author(s):

Leonie de Visser ◽

Ruud van den Bos ◽

Berry M. Spruijt

Keyword(s):

Home Cage ◽

Wheel Running ◽

Cage Floor

Automated home cage observations as a tool to measure the effects of wheel running on cage floor locomotion

Behavioural Brain Research ◽

10.1016/j.bbr.2004.12.004 ◽

2005 ◽

Vol 160 (2) ◽

pp. 382-388 ◽

Cited By ~ 51

Author(s):

Leonie de Visser ◽

Ruud van den Bos ◽

Berry M. Spruijt

Keyword(s):

Home Cage ◽

Wheel Running ◽

Cage Floor

On the Digital Psychopharmacology of Valproic Acid in Mice

10.1101/2020.07.29.220350 ◽

2020 ◽

Author(s):

John Samuel Bass ◽

Anney Tuo ◽

Linh Ton ◽

Miranda J. Jankovic ◽

Paarth K. Kapadia ◽

...

Keyword(s):

Valproic Acid ◽

Open Field ◽

Developmental Delays ◽

Home Cage ◽

Wheel Running ◽

Drug Discontinuation ◽

Fetal Exposure ◽

Daily Ingestion ◽

Field Assay ◽

Technical Advances

AbstractObjectiveAntiepileptic drugs (AEDs) require daily ingestion for maximal seizure prophylaxis. Adverse psychiatric consequences of AEDs present as: (i) reversible changes in mood, anger, anxiety and/or irritability that often necessitate drug discontinuation, and (ii) autism and/or cognitive/psychomotor developmental delays following fetal exposure. Technical advances in quantifying naturalistic rodent behaviors may provide sensitive preclinical estimates of AED psychiatric tolerability and neuropsychiatric teratogenicity.MethodsUsing instrumented home-cage monitoring, we assessed how valproic acid (VPA, dissolved in sweetened drinking water) alters home-cage behavior in adult C57BL/6J mice and in the adult offspring of VPA-exposed breeder pairs. By utilizing a pup open field assay, we also examined how prenatal VPA exposure impacts early spontaneous exploratory behavior.ResultsAt 500-600mg/kg/d, chronic VPA produced hyperphagia and increased wheel-running without impacting sleep, activity and measures of risk aversion. When applied chronically to breeder pairs of mice, VPA prolonged the latency to viable litters without affecting litter size. Two-week old VPA-exposed pups displayed open field hypoactivity without alterations in thigmotaxis. As adults, prenatal VPA-exposed mice displayed active state fragmentation, hypophagia and increased wheel running, together with subtle alterations in home-cage dyadic behavior.InterpretationThrough automated home-cage assessments of C57BL/6J mice, we capture an ethologically centered psychopharmacological profile of enterally administered VPA that is aligned with human clinical experience. By characterizing the effects of pangestational VPA exposure, we discover novel murine expressions of pervasive neurodevelopment. Incorporating rigorous comprehensive assessments of neuropsychiatric tolerability may inform the design of future AEDs with improved neuropsychiatric safety profiles, both for patients and their offspring.