Head growth during neonatal intensive care unit stay is related to the neurodevelopmental outcomes of preterm small for gestational age infants

PURPOSE: To study the incidence of retinopathy of prematurity (ROP) in a neonatal intensive care unit in Croatia and obtain information on risk factors associated with ROP. There have been limited studies on ROP in Croatia where the screening for ROP and its treatment is still insufficient and not introduced in many intensive care units. MATERIAL AND METHODS: This retrospective study included 247 premature infants admitted to the neonatal intensive care unit of University Hospital Split, over a 5-year period between January 2012, and December 2016. In this paper the relationship between clinical risk factors and the development of ROP was analyzed. RESULTS: The overall incidence for ROP was 23,9 % (59 infants), for Type 1 ROP was 9,3% (23 infants); for Type 2 ROP was 14,6% (36 infants). Median gestational age (GA) and birthweight (BW) were significantly lower among infants with ROP versus those without ROP (29: 23-34 vs. 31: 23-34,p<0,001 and 1,180:630-2,000 vs. 1485:590-2000, p<0,001 respectively). Multivariate analysis showed that only BW (p=0,029) and small for gestational age (SGA) (p=0,045) predicted the development of ROP. CONCLUSION: Birth weight and small for gestational age were the most significant risk factors for developing ROP. In comparison with studies from highly developed countries, infants with a much wider range of gestational age and birth weights are developing Type 1 ROP.

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EARLY VS LATE CAFFEINE THERAPY IN PRETERM INFANTS: ANALYSIS OF CLINICAL OUTCOME

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i2.3769 ◽

2021 ◽

Vol 71 (2) ◽

pp. 503-06

Author(s):

Hafsa Niaz ◽

Jawad Jalil ◽

Muhammad Adil ◽

Faisal Basheer ◽

Shahzad Akhtar ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Birth Weight ◽

Clinical Outcome ◽

Neonatal Intensive Care Unit ◽

Intensive Care Unit Stay ◽

Preterm Infants ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Female Ratio

Objective: To study clinical outcome of early versus late caffeine therapy in preterm infants. Study Design: Prospective comparative study. Place and Duration of Study: Neonatal Intensive Care Unit, Pak Emirates Military Hospital, Rawalpindi, from Jan to Jul 2018. Methodology: A total of 40 preterm infants with gestational age <32 weeks and birth weight <1500 grams were randomly divided into two groups on the basis of initiation of caffeine therapy i.e. group A (early caffeine group) and group B (late caffeine group). Infant’s demographic data and clinical outcomes were compared between both groups using SPSS IBM software. Results: Mean gestational age was 29.9 ± 1.19 weeks with male to female ratio of 1.5:1 Mean birth weight was 1165.3 ± 316 grams. Half (50%) of the infants were delivered by cesarean section while surfactant was given in 29 (72.5%) infants. While comparing both groups we observed that early caffeine shortens duration of Neonatal Intensive Care Unit stay (p<0.05) whereas caffeine therapy initiation timings didn’t influence the risk of development of Respiratory Distress Syndrome or need of mechanical ventilation. Conclusion: Early caffeine therapy in preterm infants is associated with decrease duration of Neonatal Intensive Care Unit stay. However further work is needed in this regards to establish its efficacy and safety.

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Increased incidence of hypospadias in small-for-gestational age infants in a neonatal intensive-care unit

BJU International ◽

10.1046/j.1464-410x.2001.00088.x ◽

2001 ◽

Vol 87 (6) ◽

pp. 548-550 ◽

Cited By ~ 62

Author(s):

J.M. Gatti ◽

A.J. Kirsch ◽

W.A. Troyer ◽

M.R. Perez-Brayfield ◽

E.A. Smith ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Gestational Age ◽

Small For Gestational Age ◽

Neonatal Intensive Care

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Relationship between insulin-like growth factor 1, leptin and ghrelin levels and catch-up growth in small for gestational age infants of 27-31 weeks during neonatal intensive care unit admission

Journal of Paediatrics and Child Health ◽

10.1111/jpc.13307 ◽

2016 ◽

Vol 53 (1) ◽

pp. 62-67 ◽

Cited By ~ 2

Author(s):

Natsuki Ohkawa ◽

Hiromichi Shoji ◽

Naho Ikeda ◽

Hiroki Suganuma ◽

Toshiaki Shimizu

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Growth Factor ◽

Intensive Care Unit Admission ◽

Neonatal Intensive Care Unit ◽

Gestational Age ◽

Small For Gestational Age ◽

Neonatal Intensive Care ◽

Insulin Like Growth Factor ◽

Catch Up

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Effect of low birth weight on neonatal mortality in preterm and small for gestational age babies in a tertiary neonatal intensive care unit in India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20162018 ◽

2016 ◽

pp. 735-738 ◽

Cited By ~ 1

Author(s):

Smitha D'Sa ◽

Deepak Pinto ◽

Anousha Anousha ◽

B. Baliga

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Birth Weight ◽

Low Birth Weight ◽

Neonatal Intensive Care Unit ◽

Neonatal Mortality ◽

Gestational Age ◽

Small For Gestational Age ◽

Neonatal Intensive Care

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Head growth during neonatal intensive care unit stay is related to neurodevelopmental outcome in preterm infants born small for gestational age

10.21203/rs.3.rs-41321/v1 ◽

2020 ◽

Author(s):

Hannah Cho ◽

Ee-Kyung Kim ◽

In Gyu Song ◽

Ju Sun Heo ◽

Seung Han Shin ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Preterm Infants ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Neurodevelopmental Outcome ◽

Z Score ◽

Neurodevelopmental Outcomes ◽

Head Growth ◽

Catch Up

Abstract Background: To investigate postnatal growth patterns and their relationship with neurodevelopment in preterm infants born small for gestational age (SGA).Methods: This study analyzed 90 infants born SGA with birth weight <1,500 g or gestational age <32 weeks. Length, weight, and head circumference (HC) were recorded at birth, 35 weeks postmenstrual age (PMA), 40 weeks PMA, and at 4, 9, and 18 months corrected age (CA). Neurodevelopmental outcomes were assessed using the Bayley-III scales at 18 months CA. Results: Z-score of HC in SGA infants increased from birth to 40 weeks PMA. Failure of head growth catch-up to 10th percentile by 4 months CA and all three parameters by 9 months CA and onwards were associated with worse neurodevelopmental outcomes. Z-score changes in head growth between birth and 35 weeks PMA were significantly associated with neurodevelopmental outcome (p=0.006, adjusted odds ratio 6.964, 95% confidence interval: 1.763-27.506). Conclusions: Head growth during neonatal intensive care unit stay were associated with neurodevelopmental outcomes in preterm SGA infants. Preterm SGA infants are predicted to have optimal neurodevelopment at 18 months CA, if the head growth catch-up is achieved by 4 months CA and length and weight by 9 months CA.

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Course of Stress during the Neonatal Intensive Care Unit Stay in Preterm Infants

Neonatology ◽

10.1159/000520513 ◽

2021 ◽

pp. 1-9

Author(s):

Nienke H. van Dokkum ◽

Marlou L.A. de Kroon ◽

Peter H. Dijk ◽

Karianne E. Kraft ◽

Sijmen A. Reijneveld ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Intensive Care Unit Stay ◽

Preterm Infants ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Clinical Characteristics ◽

Gestational Age At Birth ◽

Medical Morbidity

Introduction: Understanding the course of stress during the neonatal intensive care unit stay may provide targets for interventions. Our aim was to describe the course of stress in preterm infants during the first 28 days of life, the influence of gestational age, and associations with clinical characteristics. Methods: In a single centre prospective cohort study, we included infants with a gestational age <30 weeks and/or birth weight <1,000 g. We measured stress over the first 28 days using the Neonatal Infant Stressor Scale (NISS). We plotted daily NISS total and subcategory scores by gestational age. The subcategories were (1) nursing, (2) skin-breaking, (3) monitoring and imaging, and (4) medical morbidity-related scores. We assessed associations of cumulative NISS scores over the first 7, 14, and 28 days with clinical characteristics using regression analyses. Results: We included 45 infants, with a median gestational age of 27 weeks. The mean daily NISS score was 66.5 (SD 8.7), with highest scores in the first 7 days of life. Scores decreased the slowest for the lowest gestational ages, in particular for nursing scores, rather than skin-breaking, monitoring and imaging, and medical morbidity-related scores. Adjusted for gestational age, infants with lower Apgar scores, sepsis, intraventricular haemorrhages, and on mechanical ventilation had significantly higher cumulative NISS scores at 7, 14, and 28 days. Conclusion: NISS scores varied greatly within infants and over time, with the highest mean scores in the first week after birth. The course of declining NISS scores in the first 28 days depended on gestational age at birth.

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Epidemiology of the Large for Gestational Age (LGA) Infant Admitted to the Neonatal Intensive Care Unit (NICU)

10.26226/morressier.57d034cfd462b802923831f2 ◽

2016 ◽

Author(s):

Jose TOLOSA

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Neonatal Intensive Care Unit ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Large For Gestational Age

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Evaluation of Morbidities and Complications of Neonatal İntensive Care Unit Patients with Respiratory Disorders at Different Gestational Ages

American Journal of Perinatology ◽

10.1055/s-0041-1722942 ◽

2021 ◽

Author(s):

Erbu Yarci ◽

Fuat E. Canpolat

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Birth Weight ◽

Neonatal Intensive Care Unit ◽

Respiratory Distress ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Respiratory Diseases ◽

Respiratory Disorders ◽

Live Births

Objective Respiratory distress presented within the first few days of life is life-threatening and common problem in the neonatal period. The aim of this study is to estimate (1) the incidence of respiratory diseases in newborns and related mortality; (2) the relationship between acute neonatal respiratory disorders rates and gestational age, birth weight, and gender; and (3) the incidence of complications associated with respiratory disturbances. Study Design Only inborn patients with gestational age between 230/7 and 416/7 weeks having respiratory distress were included in the study. The data were collected from the medical records and gestational age was based on the menstrual dating. Results There were 8,474 live births between January 1, 2013 and June 30, 2013 in our hospital. A total of 1,367 newborns were hospitalized and oxygen therapy was applied in 903 of them because of respiratory distress. An acute respiratory disorder was found to be in 10.6% (903/8,474) among all live births. Mortality was 0.76% (66/8,474). The incidence of respiratory distress syndrome was 2.8% (n = 242). The occurrence of transient tachypnea of newborn was 3.1% (n = 270). Meconium aspiration syndrome, pneumonia, congenital diaphragmatic hernia, and pulmonary maladaptation and primary persistent pulmonary hypertension rates were 0.1, 0.7, 2.2, and 0%, respectively. Overall, 553 (61%) of the 903 newborns having respiratory diseases had complications. The occurrence of necrotizing enterocolitis, patent ductus arteriosus, bronchopulmonary dysplasia, intraventricular hemorrhage and air leak was 6.8, 19.8, 4.7, 24.9, and 5%, respectively. Conclusion This study offers an epidemiological perspective for respiratory disorders from a single-center level-III neonatal intensive care unit. Although number of births, premature newborns, extremely low birth weight/very low birth weight infants, and complicated pregnancies increase in years, decreasing rates of mortality and complications are very promising. As perinatal and neonatal cares are getting better in every day, we think that more promising results can be achieved over the coming years. Key Points

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Confounders for Neonatal Intensive Care Unit Admission ın Neonates of Mothers with Preeclampsia

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2018.804 ◽

2018 ◽

Vol 24 (3) ◽

pp. 162

Author(s):

Cetin Kilicci ◽

Cigdem Yayla Abide ◽

Enis Ozkaya ◽

Evrim Bostancı Ergen ◽

İlter Yenidede ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Birth Weight ◽

Intensive Care Unit Admission ◽

Neonatal Intensive Care Unit ◽

Gestational Age ◽

Neonatal Intensive Care ◽

Preterm Neonates ◽

Apgar Scores ◽

Gestational Age At Delivery

Objective: The aim of this study was to investigate the effect of some maternal and neonatal clinical parameters on the neonatal intensive care unit admission rates of neonates born to mothers who had preeclampsia. Study Design: Study included 402 singleton pregnant women with preeclampsia who admitted to Maternal-Fetal Medicine Unit of Zeynep Kamil Children and Women’s Health Training and Research Hospital. Pregnancies with uterine rupture, chorioamnionitis and congenital malformations were excluded. Some maternal and neonatal clinical characteristics were assessed to predict neonatal intensive care unit admission.Results: Among 402 neonates, 140 (35%) of them had an indication for neonatal intensive care unit admission, among 140 neonates, 136 (97%) of them were preterm neonates. Comparison of groups with and without neonatal intensive care unit admission indicated significant differences between groups in terms of gestational age, Apgar scores at 1st and 5th minutes, birth weight, some maternal laboratory parameters (Hemoglobin, hematocrit, alanine aminotransferase, aspartate aminotransferase, albumin). In multivariate analysis, among all study population, gestational age at delivery, birth weight and Apgar scores were found to be significantly associated with neonatal intensive care unit admission. On the other hand, in subgroup of term neonates, none of the variables was shown to be associated with neonatal intensive care unit admission.Conclusion: Gestational age at delivery and the birth weight are the main risk factors for neonatal intensive care unit admission of neonates born to mothers who had preeclampsia.

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