Preclinical pharmacokinetic and toxicological evaluation of MIF-1 peptidomimetic, PAOPA: Examining the pharmacology of a selective dopamine D2 receptor allosteric modulator for the treatment of schizophrenia

Peptides ◽  
2013 ◽  
Vol 42 ◽  
pp. 89-96 ◽  
Author(s):  
Mattea L. Tan ◽  
Dipannita Basu ◽  
Jacek M. Kwiecien ◽  
Rodney L. Johnson ◽  
Ram K. Mishra
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Allosteric Modulator ◽  
Toxicological Evaluation ◽  
Dopamine D2 ◽  
Selective Dopamine

scholarly journals The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Christopher J. Draper-Joyce ◽  
Ravi Kumar Verma ◽  
Mayako Michino ◽  
Jeremy Shonberg ◽  
Anitha Kopinathan ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Allosteric Modulator ◽  
Sodium Ions ◽  
Dopamine D2 ◽  
Negative Allosteric Modulator

ChemInform Abstract: New 2-Thioether-Substituted Apomorphines as Potent and Selective Dopamine D2 Receptor Agonists.

ChemInform ◽  
2011 ◽  
Vol 42 (41) ◽  
pp. no-no
Author(s):  
Reet Reinart ◽  
Zsuzsanna Gyulai ◽  
Sandor Berenyi ◽  
Sandor Antus ◽  
Argo Vonk ◽  
...  
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Agonists ◽  
Dopamine D2 ◽  
Selective Dopamine

An attempt at the hydrated imidazoline ring expansion (HIRE) of diarene-fused [1,4]diazepinones delivers selective dopamine D2 receptor ligands

Synthesis ◽  
2021 ◽  
Author(s):  
Sergey Grintsevich ◽  
Alexander V. Sapegin ◽  
Andrzej Bojarski ◽  
Beata Duszyńska ◽  
Mikhail Krasavin
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Ring Expansion ◽  
Side Chain ◽  
Receptor Ligands ◽  
Structure Activity Relationships ◽  
Dopamine D2 ◽  
Structure Activity ◽  
Imidazoline Ring ◽  
Selective Dopamine

Attempts to extend the hydrated imidazoline ring expansion (HIRE) strategy to a series of diarene-fused [1,4]diazepinones (earlier applied successfully to bis-pyrido substrate nevirapine) resulted in no ring expansion but rather 2-aminoethyl side chain expulsion. This seeming setback (setting the limitations to the HIRE methodology substrate scope) led to the discovery of selective dopamine D2 ligands with elements of structure-activity relationships.

Remoxipride, a selective dopamine D2 receptor antagonist, in tardive dyskinesia

1988 ◽  
Vol 94 (2) ◽  
Author(s):  
Ulf Andersson ◽  
Jan-Erik H�ggstr�m ◽  
Maj-Inger Nilsson ◽  
Erik Widerl�v
Keyword(s):  
Tardive Dyskinesia ◽  
Receptor Antagonist ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Selective Dopamine ◽  
Dopamine D2 Receptor Antagonist

Selective dopamine D2 receptor reduction enhances A D1 mediated oral dyskinesia in rats

Life Sciences ◽  
1986 ◽  
Vol 39 (1) ◽  
pp. 29-35 ◽  
Author(s):  
H. Rosengarten ◽  
J.W. Schweitzer ◽  
A.J. Friedhoff
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Oral Dyskinesia ◽  
Selective Dopamine
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