Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: the inhibitory role of receptor N-glycosylation

Peptides ◽  
2022 ◽  
pp. 170735
Author(s):  
Sangmin Lee
Keyword(s):  
Binding Protein ◽  
Maltose Binding Protein ◽  
Calcitonin Gene Related Peptide ◽  
Peptide Ligand ◽  
Ligand Interaction ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Inhibitory Role ◽  
Calcitonin Gene

CGRP and Migraine: The Role of Blocking Calcitonin Gene-Related Peptide Ligand and Receptor in the Management of Migraine

Drugs ◽  
2018 ◽  
Vol 78 (9) ◽  
pp. 913-928 ◽  
Author(s):  
Kasra Maasumi ◽  
Rebecca L. Michael ◽  
Alan M. Rapoport
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Peptide Ligand ◽  
Related Peptide ◽  
Calcitonin Gene

Role of calcitonin gene-related peptide in energy metabolism

Endocrine ◽  
2017 ◽  
Vol 58 (1) ◽  
pp. 3-13 ◽  
Author(s):  
William Gustavo Lima ◽  
Gleuber Henrique Marques-Oliveira ◽  
Thaís Marques da Silva ◽  
Valéria Ernestânia Chaves
Keyword(s):  
Energy Metabolism ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Role of calcitonin gene-related peptide in gastric hypersensitivity in rats

2006 ◽  
Vol 14 (25) ◽  
pp. 2484
Author(s):  
Fei-Fei Zhang ◽  
Jian-Zhong Mo ◽  
You-Ling Lv ◽  
Sheng-Liang Chen ◽  
Ming Lv ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

scholarly journals Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors

2021 ◽  
Vol 8 ◽  
Author(s):  
Giuseppe Deganutti ◽  
Silvia Atanasio ◽  
Roxana-Maria Rujan ◽  
Patrick M. Sexton ◽  
Denise Wootten ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ligand Binding ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Approved Drugs ◽  
G Protein Coupled ◽  
Dynamic Docking ◽  
Receptor Family

Class B1 G protein-coupled receptors (GPCRs) are important targets for many diseases, including cancer, diabetes, and heart disease. All the approved drugs for this receptor family are peptides that mimic the endogenous activating hormones. An understanding of how agonists bind and activate class B1 GPCRs is fundamental for the development of therapeutic small molecules. We combined supervised molecular dynamics (SuMD) and classic molecular dynamics (cMD) simulations to study the binding of the calcitonin gene-related peptide (CGRP) to the CGRP receptor (CGRPR). We also evaluated the association and dissociation of the antagonist telcagepant from the extracellular domain (ECD) of CGRPR and the water network perturbation upon binding. This study, which represents the first example of dynamic docking of a class B1 GPCR peptide, delivers insights on several aspects of ligand binding to CGRPR, expanding understanding of the role of the ECD and the receptor-activity modifying protein 1 (RAMP1) on agonist selectivity.

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