The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

2014 ◽  
Vol 141 (1) ◽  
pp. 40-54 ◽  
Author(s):  
Bernadett Kalmar ◽  
Ching-Hua Lu ◽  
Linda Greensmith
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Therapeutic Potential ◽  
Shock Proteins ◽  
Lateral Sclerosis

scholarly journals The Functions and Therapeutic Potential of Heat Shock Proteins in Inflammatory Bowel Disease—An Update

2019 ◽  
Vol 20 (21) ◽  
pp. 5331 ◽  
Author(s):  
Abdullah Hoter ◽  
Hassan Y. Naim
Keyword(s):  
Inflammatory Bowel Disease ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Bowel Disease ◽  
Therapeutic Potential ◽  
Inflammatory Bowel ◽  
Targeted Inhibition ◽  
Shock Proteins ◽  
Lines Of Evidence

Inflammatory bowel disease (IBD) is a multifactorial human intestinal disease that arises from numerous, yet incompletely defined, factors. Two main forms, Crohn’s disease (CD) and ulcerative colitis (UC), lead to a chronic pathological form. Heat shock proteins (HSPs) are stress-responsive molecules involved in various pathophysiological processes. Several lines of evidence link the expression of HSPs to the development and prognosis of IBD. HSP90, HSP70 and HSP60 have been reported to contribute to IBD in different aspects. Moreover, induction and/or targeted inhibition of specific HSPs have been suggested to ameliorate the disease consequences. In the present review, we shed the light on the role of HSPs in IBD and their targeting to prevent further disease progression.

Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis

2006 ◽  
Vol 24 (2) ◽  
pp. 213-225 ◽  
Author(s):  
Zarah Batulan ◽  
David M. Taylor ◽  
Rebecca J. Aarons ◽  
Sandra Minotti ◽  
Mohammad M. Doroudchi ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Primary Culture ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Culture Model ◽  
Shock Proteins ◽  
Lateral Sclerosis
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