Modulation of CYP3A4 and CYP2C9 activity by Bulbine natalensis and its constituents: An assessment of HDI risk of B. natalensis containing supplements

Phytomedicine ◽  
2021 ◽  
Vol 81 ◽  
pp. 153416
Author(s):  
Islam Husain ◽  
Vamshi Manda ◽  
Manal Alhusban ◽  
Olivia R. Dale ◽  
Ji-Yeong Bae ◽  
...  
Keyword(s):  
Cyp2c9 Activity

scholarly journals Impact of genetic and non-genetic factors on hepatic CYP2C9 expression and activity in Hungarian subjects

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ferenc Fekete ◽  
Katalin Mangó ◽  
Máté Déri ◽  
Evelyn Incze ◽  
Annamária Minus ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Accurate Estimation ◽  
Mrna Levels ◽  
Cytochrome P450 Enzymes ◽  
Acid Therapy ◽  
Cyp2c9 Genotype ◽  
Amoxicillin Clavulanic Acid ◽  
Inflammatory Drugs ◽  
The Impact ◽  
Cyp2c9 Activity

AbstractCYP2C9, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of 15–20% of clinically important drugs (warfarin, sulfonylureas, phenytoin, non-steroid anti-inflammatory drugs). To avoid adverse events and/or impaired drug-response, CYP2C9 pharmacogenetic testing is recommended. The impact of CYP2C9 polymorphic alleles (CYP2C9*2, CYP2C9*3) and phenoconverting non-genetic factors on CYP2C9 function and expression was investigated in liver tissues from Caucasian subjects (N = 164). The presence of CYP2C9*3 allele was associated with CYP2C9 functional impairment, and CYP2C9*2 influenced tolbutamide 4′-hydroxylase activity only in subjects with two polymorphic alleles, whereas the contribution of CYP2C8*3 was not confirmed. In addition to CYP2C9 genetic polymorphisms, non-genetic factors (co-medication with CYP2C9-specific inhibitors/inducers and non-specific factors including amoxicillin + clavulanic acid therapy or chronic alcohol consumption) contributed to the prediction of hepatic CYP2C9 activity; however, a CYP2C9 genotype–phenotype mismatch still existed in 32.6% of the subjects. Substantial variability in CYP2C9 mRNA levels, irrespective of CYP2C9 genotype, was demonstrated; however, CYP2C9 induction and non-specific non-genetic factors potentially resulting in liver injury appeared to modify CYP2C9 expression. In conclusion, complex implementation of CYP2C9 genotype and non-genetic factors for the most accurate estimation of hepatic CYP2C9 activity may improve efficiency and safety of medication with CYP2C9 substrate drugs in clinical practice.

scholarly journals Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity

2007 ◽  
Vol 63 (4) ◽  
pp. 477-487 ◽  
Author(s):  
N. K. Zgheib ◽  
R. F. Frye ◽  
T. S. Tracy ◽  
M. Romkes ◽  
R. A. Branch
Keyword(s):  
Cyp2c9 Activity

Effect of cigarette smoking on CYP2C9 activity.

2003 ◽  
Vol 73 (2) ◽  
pp. P14-P14 ◽  
Author(s):  
M. Kim ◽  
J. LaCourse ◽  
A.N. Nafziger ◽  
A.L. Wallace ◽  
A.D. Kashuba ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Cyp2c9 Activity

AB0200 CYP2C9 Activity in Turkish Patients with Rheumatoid Arthritis

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 965.3-966
Author(s):  
E.K. Ozer ◽  
I. Albayrak ◽  
M.T. Goktas
Keyword(s):  
Rheumatoid Arthritis ◽  
Turkish Patients ◽  
Cyp2c9 Activity

Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin

2006 ◽  
Vol 62 (6) ◽  
pp. 431-436 ◽  
Author(s):  
Myong-Jin Kim ◽  
Anne N. Nafziger ◽  
Angela D. M. Kashuba ◽  
Julia Kirchheiner ◽  
Steffen Bauer ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Cyp2c9 Activity

Paeoniae Radix, a traditional Chinese medicine, and CYP2C9 activity

2002 ◽  
Vol 27 (3) ◽  
pp. 229-230 ◽  
Author(s):  
Han-Jing Xie ◽  
Umit Yasar ◽  
Mia Sandberg ◽  
Anders Rane
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Paeoniae Radix ◽  
Cyp2c9 Activity

Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans

2003 ◽  
Vol 43 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Craig R. Lee ◽  
John A. Pieper ◽  
Alan L. Hinderliter ◽  
Reginald F. Frye ◽  
Joyce A. Blaisdell ◽  
...  
Keyword(s):  
Cyp2c9 Activity
Sign in / Sign up

Export Citation Format

Share Document