The role of 5-HT1A receptors of hippocampal CA1 region in anticonvulsant effects of low-frequency stimulation in amygdala kindled rats

The effect of fasciotomy on muscle tension (measured by a force transducer attached to the tendon) and interstitial fluid pressure (measured by Wick catheters in the muscle belly) was studied in the anterolateral compartments of 13 dog hindlimbs. Muscle tension and pressure were monitored in the tibialis cranialis muscle after low- and high-frequency stimulation of the peroneal nerve to produce twitch- and tetanic-type contractions. Fasciotomy decreased muscle force during the low-frequency stimulation by 16% (35.3 +/- 4.9 to 28.4 +/- 3.9 N) and during the high-frequency stimulation by 10% (60.8 %/- 4.9 to 54.8 +/- 3.9 N). Muscle pressure decreased 50% after fasciotomy under both conditions, 15 +/- 2 to 6 +/- 1 mmHg and 84 +/- 17 to 41 +/- 8 mmHg), respectively. Repeated functional evaluations during the testing procedure indicated that muscle fatigue was not a major factor in these results. It was concluded that fascia is important in the development of muscle tension and changes in interstitial pressure. Furthermore, the results raised questions concerning the merits of performing a fasciotomy for athletes with a compartment syndrome.

Download Full-text

The role of adenosine A1 receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats

Neuroscience ◽

10.1016/j.neuroscience.2008.11.008 ◽

2009 ◽

Vol 158 (4) ◽

pp. 1632-1643 ◽

Cited By ~ 29

Author(s):

M. Mohammad-Zadeh ◽

J. Mirnajafi-Zadeh ◽

Y. Fathollahi ◽

M. Javan ◽

A. Jahanshahi ◽

...

Keyword(s):

Low Frequency ◽

Perforant Path ◽

Inhibitory Effects ◽

Adenosine A1 Receptors ◽

Low Frequency Stimulation ◽

Adenosine A1 ◽

Frequency Stimulation ◽

Stimulation Of

Download Full-text

Enhanced Hippocampal CA1 LTP but Normal Spatial Learning in Inositol 1,4,5-trisphosphate 3-kinase(A)-Deficient Mice

Learning & Memory ◽

10.1101/lm.5.4.317 ◽

1998 ◽

Vol 5 (4) ◽

pp. 317-330 ◽

Cited By ~ 2

Author(s):

Kisun Jun ◽

Gildon Choi ◽

Sung-Gu Yang ◽

Kwan Yong Choi ◽

Hyun Kim ◽

...

Keyword(s):

Spatial Learning ◽

Mutant Mice ◽

Wild Type ◽

Ca1 Region ◽

Hippocampal Ca1 Region ◽

Hippocampal Ca1 ◽

Morris Water Maze Task ◽

Significant Difference ◽

Kinase A

To define the physiological role of IP33-kinase(A) in vivo, we have generated a mouse strain with a null mutation of the IP33-kinase(A) locus by gene targeting. Homozygous mutant mice were fully viable, fertile, apparently normal, and did not show any morphological anomaly in brain sections. In the mutant brain, the IP4 level was significantly decreased whereas the IP3 level did not change, demonstrating a major role of IP33-kinase(A) in the generation of IP4. Nevertheless, no significant difference was detected in the hippocampal neuronal cells of the wild-type and the mutant mice in the kinetics of Ca2+ regulation after glutamate stimulation. Electrophysiological analyses carried out in hippocampal slices showed that the mutation significantly enhanced the LTP in the hippocampal CA1 region, but had no effect on the LTP in dentate gyrus (DG). No difference was noted, however, between the mutant and the wild-type mice in the Morris water maze task. Our results indicate that IP33-kinase(A) may play an important role in the regulation of LTP in hippocampal CA1 region through the generation of IP4, but the enhanced LTP in the hippocampal CA1 does not affect spatial learning and memory.

Download Full-text