The Drosophila Circadian Phase Response Curve to Light: Conservation across Seasonally Relevant Photoperiods and Anchorage to Sunset

2021 ◽  
pp. 113691
Author(s):  
Hannah K. Dollish ◽  
Sevag Kaladchibachi ◽  
David C. Negelspach ◽  
Fabian-Xosé Fernandez
Keyword(s):  
Response Curve ◽  
Phase Response Curve ◽  
Phase Response ◽  
Circadian Phase

Synchronization of two coupled pacemaker cells based on the phase response curve

2009 ◽  
Vol 4 (1) ◽  
pp. 57-66
Author(s):  
Hossein Gholizade-Narm ◽  
Asad Azemi ◽  
Morteza Khademi ◽  
Masoud Karimi-Ghartemani
Keyword(s):  
Response Curve ◽  
Phase Response Curve ◽  
Phase Response ◽  
Pacemaker Cells

scholarly journals PDF neuron firing phase-shifts key circadian activity neurons in Drosophila

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Fang Guo ◽  
Isadora Cerullo ◽  
Xiao Chen ◽  
Michael Rosbash
Keyword(s):  
Response Curve ◽  
Phase Response Curve ◽  
Receptor Expression ◽  
Phase Shifting ◽  
Constant Darkness ◽  
Behavioral Rhythms ◽  
Circadian Phase ◽  
Phase Adjustment ◽  
Drosophila Brain ◽  
A Cell

Our experiments address two long-standing models for the function of the Drosophila brain circadian network: a dual oscillator model, which emphasizes the primacy of PDF-containing neurons, and a cell-autonomous model for circadian phase adjustment. We identify five different circadian (E) neurons that are a major source of rhythmicity and locomotor activity. Brief firing of PDF cells at different times of day generates a phase response curve (PRC), which mimics a light-mediated PRC and requires PDF receptor expression in the five E neurons. Firing also resembles light by causing TIM degradation in downstream neurons. Unlike light however, firing-mediated phase-shifting is CRY-independent and exploits the E3 ligase component CUL-3 in the early night to degrade TIM. Our results suggest that PDF neurons integrate light information and then modulate the phase of E cell oscillations and behavioral rhythms. The results also explain how fly brain rhythms persist in constant darkness and without CRY.

Light effects on circadian timing system of a diurnal primate, the squirrel monkey

1985 ◽  
Vol 249 (2) ◽  
pp. R274-R280 ◽  
Author(s):  
T. M. Hoban ◽  
F. M. Sulzman
Keyword(s):  
Squirrel Monkey ◽  
Response Curve ◽  
Phase Response Curve ◽  
Phase Response ◽  
Day Length ◽  
Circadian Timing ◽  
Subjective Night ◽  
Timing System ◽  
Circadian Timing System ◽  
Light Effects

We examined light effects on the circadian timing system of the squirrel monkey. A phase-response curve to 1-h pulses of light was constructed for the drinking rhythm of six animals. The phase-response curve was the same type as that exhibited by nocturnal rodents, with phase delays occurring early in the subjective night and phase advances late in the subjective night. The range of entrainment of 10 monkeys to days with 1 h light and x h dark was determined. Five monkeys used to generate the phase-response curve were also used in the range of entrainment determination. For short light-dark cycles the range of entrainment was smaller than that expected, with no monkey entraining to a day length of less than 23.5 h.

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