Reverse Engineering of Research Engine Cylinder-Head

The pursuit of increasing the efficiency of internal combustion engines is an ongoing engineering task that requires numerous research efforts. New concepts of injection or combustion systems require preliminary investigation work using research engines. These engines, usually single-cylinder, make it possible to isolate a single variable in a complex combustion mixture preparation process, thus enabling analysis of the changes being made. However, these engines are relatively expensive and their designs are offered by a limited number of manufacturers. The authors of this paper have successfully undertaken the engineering task of modifying an existing research engine cylinder head in such a way as to implement an electronically controlled variable valve timing system of the intake system. The process of reverse engineering, together with design assumptions that finally contributed to the construction of the assumed solution has been described in this paper.

Beat Patterns Determine Inter-Hand Differences in Synchronization Error in a Bimanual Coordination Tapping Task

A previous study reported the unique finding that people tapping a beat pattern with the right hand produce larger negative synchronization error than when tapping with the left hand or other effectors, in contrast to previous studies that have shown that the hands tap patterns simultaneously without any synchronization errors. We examined whether the inter-hand difference in synchronization error occurred due to handedness or to a specificity of the beat pattern employed in that study. Two experiments manipulated the hand–beat assignments. A comparison between the identical beat to the pacing signal and a beat with a longer interval excluded the handedness hypothesis and demonstrated that beat patterns with relatively shorter intervals were tapped earlier (Experiment 1). These synchronization errors were not local but occurred consistently throughout the beat patterns. Experiment 2 excluded alternative explanations. These results indicate that the apparent inconsistency in previous studies was due to the specificity of the beat patterns, suggesting that a beat pattern with a relatively shorter interval between hands is tapped earlier than beats with longer intervals. Our finding that the bimanual tapping of different beat patterns produced different synchronization errors suggests that the notion of a central timing system may need to be revised.

Cronobiological and Sleep Related Aspects Associated to Neurodevelopment and Academic Performance in Pediatric Age

Biological rhythms and sleep as their main representative are relevant biofunctional factors to the neuro-cognitive and behavioral development with particular interest in pediatric domain. Some aspects associated to central nervous system and higher function homeostasis, like social-afective equilibrium, critical judgement and memories consolidations and learning, have, in this phase of life, a relationship with the circadian timing system stability and with cronotype. On the other hand, inadequate or insufficient sleep has a negative impact in several biopsychosocial parameters interacting with these domains and conditioning the normal development causing changes in neuro-cognitive and behavioral performance. This review looked for the fundamental aspects of chronobiology and sleep physiology applied to neurodevelopment and its impact in the educational context regarding academic performance.

Validity of a Magnet-Based Timing System Using the Magnetometer Built into an IMU

Inertial measurement units (IMUs) represent a technology that is booming in sports right now. The aim of this study was to evaluate the validity of a new application on the use of these wearable sensors, specifically to evaluate a magnet-based timing system (M-BTS) for timing short-duration sports actions using the magnetometer built into an IMU in different sporting contexts. Forty-eight athletes (22.7 ± 3.3 years, 72.2 ± 10.3 kg, 176.9 ± 8.5 cm) and eight skiers (17.4 ± 0.8 years, 176.4 ± 4.9 cm, 67.7 ± 2.0 kg) performed a 60-m linear sprint running test and a ski slalom, respectively. The M-BTS consisted of placing several magnets along the course in both contexts. The magnetometer built into the IMU detected the peak-shaped magnetic field when passing near the magnets at a certain speed. The time between peaks was calculated. The system was validated with photocells. The 95% error intervals for the total times were less than 0.077 s for the running test and 0.050 s for the ski slalom. With the M-BTS, future studies could select and cut the signals belonging to the other sensors that are integrated in the IMU, such as the accelerometer and the gyroscope.

Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction

Based on studies describing an increased prevalence of addictive behaviours in several rare sleep disorders and shift workers, a relationship between circadian rhythms and addiction has been hinted for more than a decade. Although circadian rhythm alterations and molecular mechanisms associated with neuropsychiatric conditions are an area of active investigation, success is limited so far, and further investigations are required. Thus, even though compelling evidence connects the circadian clock to addictive behaviour and vice-versa, yet the functional mechanism behind this interaction remains largely unknown. At the molecular level, multiple mechanisms have been proposed to link the circadian timing system to addiction. The molecular mechanism of the circadian clock consists of a transcriptional/translational feedback system, with several regulatory loops, that are also intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape shows profound changes in the addictive brain, with significant alterations in histone modification, DNA methylation, and small regulatory RNAs. The combination of these two observations raises the possibility that epigenetic regulation is a common plot linking the circadian clocks with addiction, though very little evidence has been reported to date. This review provides an elaborate overview of the circadian system and its involvement in addiction, and we hypothesise a possible connection at the epigenetic level that could further link them. Therefore, we think this review may further improve our understanding of the etiology or/and pathology of psychiatric disorders related to drug addiction.

KLF10 integrates circadian timing and sugar signaling to coordinate hepatic metabolism

The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in various organs. Many KLFs show a circadian expression in the liver. Here, we show that the loss of the clock-controlled KLF10 in hepatocytes results in extensive reprogramming of the mouse liver circadian transcriptome, which in turn, alters the temporal coordination of pathways associated with energy metabolism. We also show that glucose and fructose induce Klf10, which helps mitigate glucose intolerance and hepatic steatosis in mice challenged with a sugar beverage. Functional genomics further reveal that KLF10 target genes are primarily involved in central carbon metabolism. Together, these findings show that in the liver, KLF10 integrates circadian timing and sugar metabolism related signaling, and serves as a transcriptional brake that protects against the deleterious effects of increased sugar consumption.