UPLC and ESI-MS analysis of metabolites of Rauvolfia tetraphylla L. and their spatial localization using desorption electrospray ionization (DESI) mass spectrometric imaging

The electrospray ionization (ESI) responses, defined as the area of chromatographic peak of ion [M+H]+ obtained upon HPLC/ESI-MS analysis, of three β-lactam antibiotics, namely penicillin G, ampicillin and carbenicillin have been compared with the ESI responses of their methanolysis products. It has been found that methanolyzed penicillin G has much higher ESI response than the penicillin G. Methanolyzed ampicillin also has higher ESI response than ampicillin; however, the effect is less pronounced than for penicillin. Methanolyzed carbenicillin does not have pronouncedly higher ESI response than carbenicillin.

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Desorption electrospray ionization–mass spectrometric analysis of low vapor pressure chemical particulates collected from a surface

Analytica Chimica Acta ◽

10.1016/j.aca.2014.09.042 ◽

2015 ◽

Vol 853 ◽

pp. 368-374 ◽

Cited By ~ 6

Author(s):

K.J. Ewing ◽

D. Gibson ◽

J. Sanghera ◽

F. Miklos

Keyword(s):

Vapor Pressure ◽

Electrospray Ionization ◽

Desorption Electrospray Ionization ◽

Mass Spectrometric ◽

Mass Spectrometric Analysis ◽

Spectrometric Analysis ◽

Ionization Mass ◽

Pressure Chemical

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Titelbild: Mass Spectrometric Profiling of Intact Biological Tissue by Using Desorption Electrospray Ionization (Angew. Chem. 43/2005)

Angewandte Chemie ◽

10.1002/ange.200590142 ◽

2005 ◽

Vol 117 (43) ◽

pp. 7127-7127

Author(s):

Justin M. Wiseman ◽

Satu M. Puolitaival ◽

Zoltán Takáts ◽

R. Graham Cooks ◽

Richard M. Caprioli

Keyword(s):

Electrospray Ionization ◽

Biological Tissue ◽

Desorption Electrospray Ionization ◽

Mass Spectrometric

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Modeling of a Novel Multi-Jet Emitter for ESI-MS Applications

Advances in Bioengineering, Biomedical and Safety Systems ◽

10.1115/imece2006-14401 ◽

2006 ◽

Author(s):

A. K. Sen ◽

J. Darabi ◽

D. R Knapp

Keyword(s):

Steady State ◽

Electrospray Ionization ◽

Carbon Nanofibers ◽

Volume Of Fluid ◽

Mass Spectrometric ◽

Ionization Mass ◽

Operational Parameters ◽

Suitable Candidate ◽

Esi Ms ◽

Sample Throughput

This paper presents the concept and simulation of a novel multiple electrospray emitters for electrospray ionization mass spectrometric (ESI-MS) applications. The proposed emitter is based on an array of carbon nanofibers (CNF) vertically grown around the orifice of a microscale thermoplastic capillary. The electrospray ionization process is simulated using a CFD code that utilizes Taylor-Melcher leaky-dielectric formulations for the electrohydrodynamics and volume-of-fluid (VOF) method for tracking the interface. The modeling results predict that under steady state conditions, individual cone-jets are established around each of the CNFs resulting in an array of electrosprays. Effects of several design and operational parameters on the electrospray performance are thoroughly investigated. The results of the present study will facilitate design, fabrication and experiments using the CNF emitter. Higher spray current and lower jet diameter indicate that the proposed emitter can perform equivalent to nanospray emitters exhibiting improved MS sensitivity while using a microscale orifice. Use of microscale orifice benefits in terms of higher sample throughput and eliminates potential clogging problem inherent in nanoscale capillaries. Overall, the proposed emitter is believed to be a suitable candidate for ESI-MS applications.

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