Transcriptomic investigation of the biochemical function of 7-dehydrocholesterol reductase 1 from the traditional Chinese medicinal plant Anemarrhena asphodeloides Bunge

2021 ◽  
Vol 192 ◽  
pp. 112954
Author(s):  
Yunpeng Wang ◽  
Wenbo Xiong ◽  
Yidu Chen ◽  
Min Zhu ◽  
Jincai Liang ◽  
...  
Food Control ◽  
2007 ◽  
Vol 18 (12) ◽  
pp. 1547-1554 ◽  
Author(s):  
Sheng-Hsien Lee ◽  
Ku-Shang Chang ◽  
Min-Sheng Su ◽  
Yung-Sheng Huang ◽  
Hung-Der Jang

2021 ◽  
Vol 17 (6) ◽  
pp. 1199-1207
Author(s):  
Hanmei Li ◽  
Hongyi Zhuo ◽  
Dan Yin ◽  
Wei Li ◽  
Yamei Zhang ◽  
...  

Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short, which limits its treatment effect. To avoid this problem, the present study explored the preparation of a TMP nanosuspension (TMP-NS) based on hydrophobic ion pairing. TMP-NS showed a particle size of approximately 588 nm and, after intra-articular injection in rats, it had longer retention in the articular cavity, higher TMP concentrations in joints, and greater anti-osteoarthritic efficacy than TMP solution. TMP-NS didn’t cause significant inflammation at the joint. These results suggest that TMP-NS may strengthen and prolong the therapeutic efficacy of TMP against osteoarthritis without systemic toxicity.


Planta Medica ◽  
2006 ◽  
Vol 73 (01) ◽  
pp. 91-93 ◽  
Author(s):  
Heng-Gang Xue ◽  
Song-Dong Zhou ◽  
Xing-Jin He ◽  
Yan Yu

2018 ◽  
Vol 81 (11) ◽  
pp. 2531-2538 ◽  
Author(s):  
Qi Wang ◽  
Zhenquan Hu ◽  
Xixiang Li ◽  
Aoli Wang ◽  
Hong Wu ◽  
...  

3 Biotech ◽  
2020 ◽  
Vol 10 (3) ◽  
Author(s):  
Tian-hao Liu ◽  
Xiao-mei Zhang ◽  
Shou-zheng Tian ◽  
Li-guo Chen ◽  
Jia-li Yuan

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